4L6H
Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003871 | molecular_function | 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006555 | biological_process | methionine metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009277 | cellular_component | fungal-type cell wall |
| A | 0009986 | cellular_component | cell surface |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019280 | biological_process | L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine |
| A | 0030446 | cellular_component | hyphal cell wall |
| A | 0032259 | biological_process | methylation |
| A | 0034605 | biological_process | cellular response to heat |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052553 | biological_process | symbiont-mediated perturbation of host immune response |
| A | 0062040 | cellular_component | fungal biofilm matrix |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| A | 0098609 | biological_process | cell-cell adhesion |
| A | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 801 |
| Chain | Residue |
| A | HIS657 |
| A | CYS659 |
| A | CYS739 |
| A | HCS802 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE HCS A 802 |
| Chain | Residue |
| A | ASP614 |
| A | HIS657 |
| A | CYS659 |
| A | GLY740 |
| A | ZN801 |
| A | HOH1180 |
| A | ILE446 |
| A | GLY447 |
| A | SER448 |
| A | GLU499 |
| A | MET566 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MTX A 803 |
| Chain | Residue |
| A | LYS19 |
| A | ASP504 |
| A | SER526 |
| A | TYR527 |
| A | ARG530 |
| A | TYR531 |
| A | VAL532 |
| A | PRO535 |
| A | TRP576 |
| A | HOH981 |
| A | HOH1315 |
| A | HOH1345 |
| A | HOH1481 |
| A | HOH1542 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"25545590","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24524835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25545590","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L64","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QQU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24524835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25545590","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QQU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24524835","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L65","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24524835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25545590","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L64","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QQU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21689631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24524835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25545590","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PPC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L64","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QQU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21689631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24524835","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L64","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L6O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
