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7XUG
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BU of 7xug by Molmil
cryo-EM structure of HK022 putRNA-less E.coli RNA polymerase elongation complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Hwang, S, Kang, J.Y.
Deposit date:2022-05-18
Release date:2022-08-10
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA.
Nat Commun, 13, 2022
7XUI
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BU of 7xui by Molmil
Cryo-EM structure of sigma70 bound HK022 putRNA-associated E.coli RNA polymerase elongation complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Hwang, S, Kang, J.Y.
Deposit date:2022-05-18
Release date:2022-08-10
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA.
Nat Commun, 13, 2022
1GFG
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BU of 1gfg by Molmil
CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
Descriptor: LYSOZYME, SODIUM ION
Authors:Funahashi, J, Takano, K, Yamagata, Y, Yutani, K.
Deposit date:2000-12-04
Release date:2000-12-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Positive contribution of hydration structure on the surface of human lysozyme to the conformational stability.
J.Biol.Chem., 277, 2002
217D
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BU of 217d by Molmil
CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN
Descriptor: DISTAMYCIN A, DNA/RNA (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3'), MAGNESIUM ION
Authors:Chen, X, Ramakrishnan, B, Sundaralingam, M.
Deposit date:1995-07-18
Release date:1996-01-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of B-form DNA-RNA chimers complexed with distamycin.
Nat.Struct.Biol., 2, 1995
1L45
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BU of 1l45 by Molmil
CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
Descriptor: T4 LYSOZYME
Authors:Daopin, S, Matthews, B.W.
Deposit date:1991-01-28
Release date:1991-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
J.Mol.Biol., 221, 1991
1GFR
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BU of 1gfr by Molmil
CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
Descriptor: LYSOZYME, SODIUM ION
Authors:Funahashi, J, Takano, K, Yamagata, Y, Yutani, K.
Deposit date:2000-12-04
Release date:2000-12-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Positive contribution of hydration structure on the surface of human lysozyme to the conformational stability.
J.Biol.Chem., 277, 2002
1L55
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BU of 1l55 by Molmil
ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:Nicholson, H, Matthews, B.W.
Deposit date:1991-05-06
Release date:1991-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
Biochemistry, 30, 1991
5CLE
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BU of 5cle by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing an abasic-site analog and a free 3-methyladenine nucleobase
Descriptor: 3-METHYL-3H-PURIN-6-YLAMINE, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(3DR)P*AP*GP*TP*CP*CP*G)-3'), ...
Authors:Mullins, E.A, Eichman, B.F.
Deposit date:2015-07-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
1LGV
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BU of 1lgv by Molmil
Structure of a Human Bence-Jones Dimer Crystallized in U.S. Space Shuttle Mission STS-95: 100K
Descriptor: IMMUNOGLOBULIN LAMBDA LIGHT CHAIN
Authors:Terzyan, S.S, DeWitt, C.R, Ramsland, P.A, Bourne, P.C, Edmundson, A.B.
Deposit date:2002-04-16
Release date:2003-07-01
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95
J.MOL.RECOG., 16, 2003
4PTG
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BU of 4ptg by Molmil
Structure of a carboxamine compound (26) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-METHOXYPYRIMIDINE-5-CARBOXAMIDE) to GSK3b
Descriptor: 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide, Glycogen synthase kinase-3 beta
Authors:Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M.
Deposit date:2014-03-10
Release date:2015-04-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.361 Å)
Cite:Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg.Med.Chem.Lett., 25, 2015
5CLV
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BU of 5clv by Molmil
Crystal Structure of KorA-operator DNA complex (KorA-OA)
Descriptor: 5'-D(CP*CP*AP*AP*GP*TP*TP*TP*AP*GP*CP*TP*AP*AP*AP*CP*TP*TP*GP*GP*)-3', TrfB transcriptional repressor protein
Authors:White, S.A, Hyde, E.I, Rajasekar, K.V.
Deposit date:2015-07-16
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Flexibility of KorA, a plasmid-encoded, global transcription regulator, in the presence and the absence of its operator.
Nucleic Acids Res., 44, 2016
2CBL
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BU of 2cbl by Molmil
N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70
Descriptor: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70
Authors:Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
Deposit date:1998-08-28
Release date:1999-05-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
6KHD
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BU of 6khd by Molmil
Crystal structure of CLK1 in complex with CX-4945
Descriptor: 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Dual specificity protein kinase CLK1
Authors:Lee, J.Y, Yun, J.S, Jin, H, Chang, J.H.
Deposit date:2019-07-15
Release date:2019-10-02
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.
Biomed Res Int, 2019, 2019
1L69
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BU of 1l69 by Molmil
MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:Zhang, X, Matthews, B.W.
Deposit date:1991-09-23
Release date:1991-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
Protein Sci., 1, 1992
5CL3
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BU of 5cl3 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog (100% substrate at 4 hours)
Descriptor: AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(DZM)P*AP*GP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*CP*TP*TP*TP*CP*GP*GP*G)-3')
Authors:Mullins, E.A, Eichman, B.F.
Deposit date:2015-07-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.971 Å)
Cite:The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
1GN9
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BU of 1gn9 by Molmil
Hybrid Cluster Protein from Desulfovibrio desulfuricans ATCC 27774 X-ray structure at 2.6A resolution using synchrotron radiation at a wavelength of 1.722A
Descriptor: HYBRID CLUSTER PROTEIN, IRON/SULFUR CLUSTER, IRON/SULFUR/OXYGEN HYBRID CLUSTER
Authors:Macedo, S, Mitchell, E.P, Romao, C.V, Cooper, S.J, Coelho, R, Liu, M.Y, Xavier, A.V, Legall, J, Bailey, S, Garner, D.C, Hagen, W.R, Teixeira, M, Carrondo, M.A, Lindley, P.
Deposit date:2001-10-04
Release date:2002-04-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Hybrid Cluster Proteins (Hcps) from Desulfovibrio Desulfuricans Atcc 27774 and Desulfovibrio Vulgaris (Hildenborough): X-Ray Structures at 1.25 A Resolution Using Synchrotron Radiation.
J.Biol.Inorg.Chem., 7, 2002
5CL8
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BU of 5cl8 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing an abasic site and a free nucleobase (100% product at 144 hours)
Descriptor: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(ORP)P*AP*GP*TP*CP*CP*G)-3'), ...
Authors:Mullins, E.A, Eichman, B.F.
Deposit date:2015-07-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
2C7I
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BU of 2c7i by Molmil
Structure of protein Ta0514, putative lipoate protein ligase from T. acidophilum.
Descriptor: PUTATIVE LIPOATE PROTEIN LIGASE
Authors:Mcmanus, E, Perham, R.N, Luisi, B.F.
Deposit date:2005-11-24
Release date:2005-12-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of a Putative Lipoate Protein Ligase from Thermoplasma Acidophilum and the Mechanism of Target Selection for Post-Translational Modification.
J.Mol.Biol., 356, 2006
1ZUI
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BU of 1zui by Molmil
Structural Basis for Shikimate-binding Specificity of Helicobacter pylori Shikimate Kinase
Descriptor: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, PHOSPHATE ION, Shikimate kinase
Authors:Cheng, W.C, Chang, Y.N, Wang, W.C.
Deposit date:2005-05-31
Release date:2006-05-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for shikimate-binding specificity of Helicobacter pylori shikimate kinase
J.Bacteriol., 187, 2005
2CLQ
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BU of 2clq by Molmil
Structure of mitogen-activated protein kinase kinase kinase 5
Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5, STAUROSPORINE
Authors:Bunkoczi, G, Salah, E, Fedorov, O, Pike, A, Gileadi, O, von Delft, F, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Knapp, S.
Deposit date:2006-04-28
Release date:2006-05-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Functional Characterization of the Human Protein Kinase Ask1.
Structure, 15, 2007
1L85
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BU of 1l85 by Molmil
SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Eriksson, A.E, Matthews, B.W.
Deposit date:1992-01-21
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences.
J.Mol.Biol., 229, 1993
1FWC
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BU of 1fwc by Molmil
KLEBSIELLA AEROGENES UREASE, C319A VARIANT AT PH 8.5
Descriptor: NICKEL (II) ION, UREASE
Authors:Pearson, M.A, Karplus, P.A.
Deposit date:1997-04-23
Release date:1997-10-15
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Cys319 variants and acetohydroxamate-inhibited Klebsiella aerogenes urease.
Biochemistry, 36, 1997
1L8H
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BU of 1l8h by Molmil
DNA PROTECTION AND BINDING BY E. COLI DPS PROTEIN
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA PROTECTION DURING STARVATION PROTEIN, POTASSIUM ION
Authors:Luo, J, Liu, D, White, M.A, Fox, R.O.
Deposit date:2002-03-20
Release date:2003-06-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:DNA Protection and Binding by E. Coli Dps Protein
To be Published
1KY1
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BU of 1ky1 by Molmil
METHIONINE CORE MUTANT OF T4 LYSOZYME
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W.
Deposit date:2002-02-01
Release date:2003-06-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
BIOPHYS.CHEM., 100, 2003
5CRA
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BU of 5cra by Molmil
Structure of the SdeA DUB Domain
Descriptor: METHYL 4-AMINOBUTANOATE, Polyubiquitin-B, SULFATE ION, ...
Authors:Sheedlo, M.J, Qiu, J, Luo, Z.Q, Das, C.
Deposit date:2015-07-22
Release date:2015-11-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination.
Proc.Natl.Acad.Sci.USA, 112, 2015

224004

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