217D

CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN

Summary for 217D

• Entry DOI: 10.2210/pdb217d/pdb
• Descriptor: DNA/RNA (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3'), DISTAMYCIN A, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: b-dna/rna, double helix, complexed with drug, modified, dna-rna hybrid
• Total number of polymer chains: 1
• Total formula weight: 2906.35

Authors

Chen, X.,Ramakrishnan, B.,Sundaralingam, M. (deposition date: 1995-07-18, release date: 1996-01-29, Last modification date: 2024-02-14)

Primary citation

Chen, X.,Ramakrishnan, B.,Sundaralingam, M.
Crystal structures of B-form DNA-RNA chimers complexed with distamycin.
Nat.Struct.Biol., 2:733-735, 1995

PubMed Abstract: Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.

PubMed: 7552741
DOI: 10.1038/nsb0995-733

Experimental method

X-RAY DIFFRACTION (1.7 Å)