6KHD

Crystal structure of CLK1 in complex with CX-4945

Summary for 6KHD

Entry DOI	10.2210/pdb6khd/pdb
Descriptor	Dual specificity protein kinase CLK1, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (3 entities in total)
Functional Keywords	cdc2-like kinase, casein kinase, cx-4945, alternative splicing, splicing, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	173017.34
Authors	Lee, J.Y.,Yun, J.S.,Jin, H.,Chang, J.H. (deposition date: 2019-07-15, release date: 2019-10-02, Last modification date: 2024-03-27)
Primary citation	Lee, J.Y.,Yun, J.S.,Kim, W.K.,Chun, H.S.,Jin, H.,Cho, S.,Chang, J.H. Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945. Biomed Res Int, 2019:6125068-6125068, 2019 Cited by PubMed: 31531359 DOI: 10.1155/2019/6125068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation