6KHD

Crystal structure of CLK1 in complex with CX-4945

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006468	biological_process	protein phosphorylation
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0031965	cellular_component	nuclear membrane
A	0043484	biological_process	regulation of RNA splicing
A	0106310	molecular_function	protein serine kinase activity
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006468	biological_process	protein phosphorylation
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0031965	cellular_component	nuclear membrane
B	0043484	biological_process	regulation of RNA splicing
B	0106310	molecular_function	protein serine kinase activity
C	0000166	molecular_function	nucleotide binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006468	biological_process	protein phosphorylation
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0031965	cellular_component	nuclear membrane
C	0043484	biological_process	regulation of RNA splicing
C	0106310	molecular_function	protein serine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 3NG A 1000

Chain	Residue
A	LEU167
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	GLY168
A	GLU169
A	PHE172
A	VAL175
A	ALA189
A	LYS191
A	GLU206
A	PHE241

---

site_id	AC2
Number of Residues	13
Details	binding site for residue 3NG B 1000

Chain	Residue
B	LEU167
B	GLY168
B	GLU169
B	VAL175
B	ALA189
B	LYS191
B	GLU206
B	PHE241
B	GLU242
B	LEU243
B	LEU244
B	LEU295
B	ASP325

---

site_id	AC3
Number of Residues	14
Details	binding site for residue 3NG C 1000

Chain	Residue
C	LEU167
C	GLY168
C	GLU169
C	PHE172
C	VAL175
C	ALA189
C	LYS191
C	GLU206
C	PHE241
C	GLU242
C	LEU243
C	LEU244
C	LEU295
C	VAL324

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVVeCidhkaggrh.........VAVK

Chain	Residue	Details
A	LEU167-LYS191

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LtHtDLKpeNILF

Chain	Residue	Details
A	LEU284-PHE296

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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