7XYI
| HapR Quadruple mutant Y76F, L97I, I141V, F171C | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hemagglutinin/protease regulatory protein | Authors: | Basu Choudhury, G, Chaudhari, V, Ray Chaudhuri, S, Datta, S. | Deposit date: | 2022-06-01 | Release date: | 2023-02-22 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Diversity in the ligand binding pocket of HapR attributes to its uniqueness towards several inhibitors with respect to other homologues - A structural and molecular perspective. Int.J.Biol.Macromol., 233, 2023
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7XXO
| HapR Native in CHES buffer pH 9.5 | Descriptor: | Hemagglutinin/protease regulatory protein | Authors: | Basu Choudhury, G, Chaudhari, V, Ray Chaudhuri, S, Datta, S. | Deposit date: | 2022-05-30 | Release date: | 2023-02-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.487 Å) | Cite: | Diversity in the ligand binding pocket of HapR attributes to its uniqueness towards several inhibitors with respect to other homologues - A structural and molecular perspective. Int.J.Biol.Macromol., 233, 2023
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7XY5
| HapR_Double Mutant with CHES buffer | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hemagglutinin/protease regulatory protein | Authors: | Basu Choudhury, G, Chaudhari, V, Ray Chaudhuri, S, Datta, S. | Deposit date: | 2022-05-31 | Release date: | 2023-02-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Diversity in the ligand binding pocket of HapR attributes to its uniqueness towards several inhibitors with respect to other homologues - A structural and molecular perspective. Int.J.Biol.Macromol., 233, 2023
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7XXT
| HapR Quadruple mutant, bound to IMTVC-212 | Descriptor: | 1-((5-phenylthiophen-2-yl)sulfonyl)-1H-pyrazole, DIMETHYL SULFOXIDE, Hemagglutinin/protease regulatory protein | Authors: | Basu Choudhury, G, Chaudhari, V, Ray Chaudhuri, S, Datta, S. | Deposit date: | 2022-05-30 | Release date: | 2023-02-22 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Diversity in the ligand binding pocket of HapR attributes to its uniqueness towards several inhibitors with respect to other homologues - A structural and molecular perspective. Int.J.Biol.Macromol., 233, 2023
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1Q1B
| Crystal structure of E. coli MalK in the nucleotide-free form | Descriptor: | Maltose/maltodextrin transport ATP-binding protein malK | Authors: | Chen, J, Lu, G, Lin, J, Davidson, A.L, Quiocho, F.A. | Deposit date: | 2003-07-18 | Release date: | 2003-09-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A tweezer-like motion of the ATP-binding cassette dimer in an ABC transport cycle Mol.Cell, 12, 2003
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2HR3
| Crystal structure of putative transcriptional regulator protein from Pseudomonas aeruginosa PA01 at 2.4 A resolution | Descriptor: | Probable transcriptional regulator | Authors: | Kirillova, O, Chruszcz, M, Evdokimova, E, Kudritska, M, Cymborowski, M, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2006-07-19 | Release date: | 2006-09-19 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of putative transcriptional regulator protein from Pseudomonas aeruginosa PA01 at 2.4 A resolution To be Published
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3BGQ
| Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2 | Descriptor: | N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine, Proto-oncogene serine/threonine-protein kinase Pim-1 | Authors: | Jacobs, M.D. | Deposit date: | 2007-11-27 | Release date: | 2007-12-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Docking study yields four novel inhibitors of the protooncogene pim-1 kinase. J.Med.Chem., 51, 2008
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3BGP
| Human Pim-1 complexed with a benzoisoxazole inhibitor VX1 | Descriptor: | 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine, Proto-oncogene serine/threonine-protein kinase Pim-1 | Authors: | Jacobs, M.D. | Deposit date: | 2007-11-27 | Release date: | 2007-12-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Docking study yields four novel inhibitors of the protooncogene pim-1 kinase. J.Med.Chem., 51, 2008
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4ZZN
| Human ERK2 in complex with an inhibitor | Descriptor: | 2-[[5-chloranyl-2-(oxan-4-ylamino)pyridin-4-yl]amino]-N-methyl-benzamide, MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION | Authors: | Ward, R.A, Colclough, N, Challinor, M, Debreczeni, J.E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, James, M, Jones, C.D, Jones, C.R, Renshaw, J, Roberts, K, Snow, L, Tonge, M, Yeung, K. | Deposit date: | 2015-04-10 | Release date: | 2015-05-27 | Last modified: | 2015-08-26 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2. J.Med.Chem., 58, 2015
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2K8P
| Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation | Descriptor: | Sclerostin | Authors: | Veverka, V, Henry, A.J, Slocombe, P.M, Ventom, A, Mulloy, B, Muskett, F.W, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, R.J, Robinson, M.K, Carr, M.D. | Deposit date: | 2008-09-18 | Release date: | 2009-02-17 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation J.Biol.Chem., 284, 2009
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6GZH
| Crystal Structure of Human CDK9/cyclinT1 with A86 | Descriptor: | Cyclin-T1, Cyclin-dependent kinase 9, GLYCEROL, ... | Authors: | Ben-neriah, Y, Venkatachalam, A, Minzel, W, Fink, A, Snir-Alkalay, I, Vacca, J. | Deposit date: | 2018-07-04 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell, 175, 2018
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4ZZM
| Human ERK2 in complex with an irreversible inhibitor | Descriptor: | 7-ethylsulfonyl-N-(oxan-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amine, MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION | Authors: | Ward, R.A, Colclough, N, Challinor, M, Debreczeni, J.E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, James, M, Jones, C.D, Jones, C.R, Renshaw, J, Roberts, K, Snow, L, Tonge, M, Yeung, K. | Deposit date: | 2015-04-10 | Release date: | 2015-05-27 | Last modified: | 2015-08-26 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2. J.Med.Chem., 58, 2015
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2H24
| Crystal structure of human IL-10 | Descriptor: | Interleukin-10 | Authors: | Yoon, S.I, Walter, M.R. | Deposit date: | 2006-05-18 | Release date: | 2006-10-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J.Biol.Chem., 281, 2006
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3B5K
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5W2L
| Structure of a central domain of human Ctc1 | Descriptor: | CST complex subunit CTC1, MERCURY (II) ION | Authors: | Rice, C, Skordalakes, E. | Deposit date: | 2017-06-06 | Release date: | 2017-11-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes. Nucleic Acids Res., 46, 2018
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2EFR
| Crystal structure of the c-terminal tropomyosin fragment with N- and C-terminal extensions of the leucine zipper at 1.8 angstroms resolution | Descriptor: | General control protein GCN4 and Tropomyosin 1 alpha chain | Authors: | Minakata, S, Nitanai, Y, Maeda, K, Oda, N, Wakabayashi, K, Maeda, Y. | Deposit date: | 2007-02-23 | Release date: | 2008-03-04 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Two crystal structures of tropomyosin C-terminal fragment 176-273: exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule To be Published
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1T33
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2B22
| Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat | Descriptor: | General control protein GCN4, SODIUM ION | Authors: | Deng, Y, Liu, J, Zheng, Q, Eliezer, D, Kallenbach, N.R, Lu, M. | Deposit date: | 2005-09-16 | Release date: | 2006-01-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure, 14, 2006
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2KA4
| NMR structure of the CBP-TAZ1/STAT2-TAD complex | Descriptor: | Crebbp protein, Signal transducer and activator of transcription 2, ZINC ION | Authors: | Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2008-10-30 | Release date: | 2009-04-21 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains Embo J., 28, 2009
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1V06
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2B1F
| Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat | Descriptor: | General control protein GCN4 | Authors: | Deng, Y, Liu, J, Zheng, Q, Eliezer, D, Kallenbach, N.R, Lu, M. | Deposit date: | 2005-09-15 | Release date: | 2006-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure, 14, 2006
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3BGR
| Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor | Descriptor: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, Reverse transcriptase/ribonuclease H, ... | Authors: | Das, K, Bauman, J.D, Clark Jr, A.D, Shatkin, A.J, Arnold, E. | Deposit date: | 2007-11-27 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3BJ6
| Crystal structure of MarR family transcription regulator SP03579 | Descriptor: | ETHANOL, Transcriptional regulator, MarR family | Authors: | Kim, Y, Volkart, L, Keigher, L, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2007-12-03 | Release date: | 2007-12-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Crystal Structure of MarR family Transcription Regulator SP03579. To be Published
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2HY6
| A seven-helix coiled coil | Descriptor: | General control protein GCN4, HEXANE-1,6-DIOL | Authors: | Liu, J, Zheng, Q, Deng, Y, Cheng, C.S, Kallenbach, N.R, Lu, M. | Deposit date: | 2006-08-04 | Release date: | 2006-10-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | A seven-helix coiled coil. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1Q12
| Crystal Structure of the ATP-bound E. coli MalK | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Maltose/maltodextrin transport ATP-binding protein malK | Authors: | Chen, J, Lu, G, Lin, J, Davidson, A.L, Quiocho, F.A. | Deposit date: | 2003-07-18 | Release date: | 2003-09-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle Mol.Cell, 12, 2003
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