NMR structure of the CBP-TAZ1/STAT2-TAD complex

Summary for 2KA4

DescriptorCrebbp protein, Signal transducer and activator of transcription 2, ZINC ION (3 entities in total)
Functional Keywordscbp/p300, stat2, taz1, transactivation domain, bromodomain, activator, alternative splicing, antiviral defense, cytoplasm, dna-binding, host-virus interaction, nucleus, phosphoprotein, polymorphism, sh2 domain, transcription, transcription regulation, transcription regulator
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total molecular weight17907.6
Wojciak, J.M.,Martinez-Yamout, M.A.,Dyson, H.J.,Wright, P.E. (deposition date: 2008-10-30, release date: 2009-04-21, Last modification date: 2020-02-19)
Primary citation
Wojciak, J.M.,Martinez-Yamout, M.A.,Dyson, H.J.,Wright, P.E.
Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains
Embo J., 28:948-958, 2009
PubMed: 19214187 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2009.30
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers2 0.4% 7.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload