4ZZM

Human ERK2 in complex with an irreversible inhibitor

Summary for 4ZZM

Entry DOI	10.2210/pdb4zzm/pdb
Related	4ZZN 4ZZO
Descriptor	MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION, 7-ethylsulfonyl-N-(oxan-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amine, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains	1
Total formula weight	41214.44
Authors	Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.E.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K. (deposition date: 2015-04-10, release date: 2015-05-27, Last modification date: 2015-08-26)
Primary citation	Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K. Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2. J.Med.Chem., 58:4790-, 2015 Cited by PubMed: 25977981 DOI: 10.1021/ACS.JMEDCHEM.5B00466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation