4ZZM
Human ERK2 in complex with an irreversible inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | MITOGEN-ACTIVATED PROTEIN KINASE 1 | polymer | 350 | 40792.0 | 1 | UniProt (P28482) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | MAP KINASE 1, MAPK 1, ERT1, EXTRACELLULAR SIGNAL-REGULATED KINASE 2, ERK-2, MAP KINASE ISOFORM P42, P42-MAPK, MITOGEN-ACTIVATED PROTEIN KINASE 2, MAP KINASE 2, MAPK 2 |
2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
3 | A | 7-ethylsulfonyl-N-(oxan-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amine | non-polymer | 326.4 | 1 | Chemie (CQ6) | |||
4 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A: 11 - 360 (UniProt: P28482)
PDB | External Database | Details |
---|---|---|
Leu 46 | Val 46 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40792.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 422.5 | |
All* | Total formula weight | 41214.4 |