4ZZO

Human ERK2 in complex with an irreversible inhibitor

Summary for 4ZZO

• Entry DOI: 10.2210/pdb4zzo/pdb
• Related: 4ZZM 4ZZN
• Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION, N-[2-[[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]amino]phenyl]propanamide, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm, cytoskeleton, spindle : P28482
• Total number of polymer chains: 1
• Total formula weight: 41263.88

Authors

Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.E.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K. (deposition date: 2015-04-10, release date: 2015-05-27, Last modification date: 2015-08-26)

• Primary citation: Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K.; Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2.; J.Med.Chem., 58:4790-, 2015; PubMed: 25977981; DOI: 10.1021/ACS.JMEDCHEM.5B00466

Experimental method

X-RAY DIFFRACTION (1.63 Å)