4ZZM
Human ERK2 in complex with an irreversible inhibitor
Summary for 4ZZM
Entry DOI | 10.2210/pdb4zzm/pdb |
Related | 4ZZN 4ZZO |
Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION, 7-ethylsulfonyl-N-(oxan-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 1 |
Total formula weight | 41214.44 |
Authors | Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.E.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K. (deposition date: 2015-04-10, release date: 2015-05-27, Last modification date: 2015-08-26) |
Primary citation | Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K. Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2. J.Med.Chem., 58:4790-, 2015 Cited by PubMed: 25977981DOI: 10.1021/ACS.JMEDCHEM.5B00466 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
Download full validation report