4P62
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5HH6
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5HIO
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5HIP
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5JQJ
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3T9M
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5K4M
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2Q0I
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![BU of 2q0i by Molmil](/molmil-images/mine/2q0i) | Structure of Pseudomonas Quinolone Signal Response Protein PqsE | Descriptor: | BENZOIC ACID, FE (III) ION, Quinolone signal response protein | Authors: | Yu, S, Jensen, V, Feldmann, I, Haussler, S, Blankenfeldt, W. | Deposit date: | 2007-05-22 | Release date: | 2008-06-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein. Biochemistry, 48, 2009
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5K48
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![BU of 5k48 by Molmil](/molmil-images/mine/5k48) | VIM-2 Metallo Beta Lactamase in complex with 3-(mercaptomethyl)-[1,1'-biphenyl]-4-carboxylic acid | Descriptor: | 4-phenyl-2-(sulfanylmethyl)benzoic acid, Beta-lactamase VIM-2, FORMIC ACID, ... | Authors: | Zollman, D, McDonough, M, Brem, J, Schofield, C. | Deposit date: | 2016-05-20 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.744 Å) | Cite: | In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-beta-lactamase Inhibitors. J. Med. Chem., 61, 2018
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4RL0
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![BU of 4rl0 by Molmil](/molmil-images/mine/4rl0) | Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins | Descriptor: | (2R,5S)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase NDM-1, ZINC ION | Authors: | Feng, H, Ding, J, Zhu, D, Liu, X, Xu, X, Zhang, Y, Zang, S, Wang, D.-C, Liu, W. | Deposit date: | 2014-10-14 | Release date: | 2014-11-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins. J.Am.Chem.Soc., 136, 2014
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3RKJ
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![BU of 3rkj by Molmil](/molmil-images/mine/3rkj) | Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae | Descriptor: | Beta-lactamase NDM-1, GLYCEROL, SULFATE ION | Authors: | Kim, Y, Tesar, C, Jedrzejczak, R, Binkowski, T.A, Babnigg, G, Sacchettini, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) | Deposit date: | 2011-04-18 | Release date: | 2011-05-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Apo- and Monometalated Forms of NDM-1 A Highly Potent Carbapenem-Hydrolyzing Metallo-beta-Lactamase Plos One, 6, 2011
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2P4Z
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2Q0J
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![BU of 2q0j by Molmil](/molmil-images/mine/2q0j) | Structure of Pseudomonas Quinolone Signal Response Protein PqsE | Descriptor: | BENZOIC ACID, FE (III) ION, Quinolone signal response protein | Authors: | Yu, S, Jensen, V, Feldmann, I, Haussler, S, Blankenfeldt, W. | Deposit date: | 2007-05-22 | Release date: | 2008-06-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein. Biochemistry, 48, 2009
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3AJ3
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![BU of 3aj3 by Molmil](/molmil-images/mine/3aj3) | Crystal structure of selenomethionine substituted 4-pyridoxolactonase from Mesorhizobium loti | Descriptor: | 4-pyridoxolactonase, PHOSPHATE ION, ZINC ION | Authors: | Kobayashi, J, Yoshikane, Y, Baba, S, Mikami, B, Yagi, T. | Deposit date: | 2010-05-21 | Release date: | 2011-05-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.577 Å) | Cite: | Structure of 4-pyridoxolactonase from Mesorhizobium loti. Acta Crystallogr.,Sect.F, 70, 2014
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4TZ9
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![BU of 4tz9 by Molmil](/molmil-images/mine/4tz9) | Structure of Metallo-beta-lactamase | Descriptor: | CADMIUM ION, COBALT (II) ION, Class B metallo-beta-lactamase, ... | Authors: | Ferguson, J.A, Brem, J, Makena, A, McDonough, A.M, Schofield, C.J. | Deposit date: | 2014-07-09 | Release date: | 2015-07-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1269 Å) | Cite: | Structure of Metallo-beta-lactamase To Be Published
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4TZE
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![BU of 4tze by Molmil](/molmil-images/mine/4tze) | Structure of metallo-beta-lactamase | Descriptor: | Class B carbapenemase NDM-5, ZINC ION | Authors: | Ferguson, J.A, Makena, A, Brem, J, McDonough, M.A, Schofield, C.J. | Deposit date: | 2014-07-10 | Release date: | 2015-07-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.574 Å) | Cite: | stucuture of metallo-beta-lactamase To Be Published
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3SD9
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3ADR
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![BU of 3adr by Molmil](/molmil-images/mine/3adr) | The first crystal structure of an archaeal metallo-beta-lactamase superfamily protein; ST1585 from Sulfolobus tokodaii | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Putative uncharacterized protein ST1585, ... | Authors: | Shimada, A, Ishikawa, H, Nakagawa, N, Kuramitsu, S, Masui, R. | Deposit date: | 2010-01-28 | Release date: | 2010-04-21 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The first crystal structure of an archaeal metallo-beta-lactamase superfamily protein; ST1585 from Sulfolobus tokodaii Proteins, 78, 2010
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2QDS
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2QJS
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6IBS
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![BU of 6ibs by Molmil](/molmil-images/mine/6ibs) | Crystal structure of NDM-1 beta-lactamase in complex with boronic inhibitor cpd 6 | Descriptor: | CALCIUM ION, Metallo-beta-lactamase type 2, ZINC ION, ... | Authors: | Maso, L, Quotadamo, A, Bellio, P, Montanari, M, Venturelli, A, Celenza, G, Costi, M.P, Tondi, D, Cendron, L. | Deposit date: | 2018-11-30 | Release date: | 2019-04-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid beta-Lactamase Inhibitors. Acs Med.Chem.Lett., 10, 2019
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6ZYQ
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![BU of 6zyq by Molmil](/molmil-images/mine/6zyq) | Structure of NDM-1 with 2-Mercaptomethyl-thiazolidine D-syn-1b | Descriptor: | (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Metallo-beta-lactamase type 2, SULFATE ION, ... | Authors: | Hinchliffe, P, Spencer, J. | Deposit date: | 2020-08-02 | Release date: | 2021-01-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12, 2021
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7A5Z
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![BU of 7a5z by Molmil](/molmil-images/mine/7a5z) | Structure of VIM-2 metallo-beta-lactamase with hydrolysed Faropenem imine product | Descriptor: | (5~{Z})-2-[1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-(4-oxidanylbutylidene)-2~{H}-1,3-thiazole-4-carboxylic acid, Beta-lactamase VIM-2, CHLORIDE ION, ... | Authors: | Lucic, A, Schofield, C.J. | Deposit date: | 2020-08-24 | Release date: | 2021-02-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215, 2021
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7A60
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![BU of 7a60 by Molmil](/molmil-images/mine/7a60) | Crystal structure of VIM-2 with hydrolyzed faropenem (ring-open form) | Descriptor: | (5~{Z})-2-[1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-(4-oxidanylbutylidene)-2~{H}-1,3-thiazole-4-carboxylic acid, Beta-lactamase VIM-2, FORMIC ACID, ... | Authors: | Hinchliffe, P, Spencer, J. | Deposit date: | 2020-08-24 | Release date: | 2021-02-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215, 2021
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7A63
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![BU of 7a63 by Molmil](/molmil-images/mine/7a63) | Crystal structure of L1 with hydrolyzed faropenem (imine, ring-closed form) | Descriptor: | (2R,5S)-2-[(1S,2R)-1-carboxy-2-hydroxy-propyl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydrothiazole-4-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ... | Authors: | Hinchliffe, P, Spencer, J. | Deposit date: | 2020-08-24 | Release date: | 2021-02-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.57000113 Å) | Cite: | Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215, 2021
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