7A63
Crystal structure of L1 with hydrolyzed faropenem (imine, ring-closed form)
Summary for 7A63
| Entry DOI | 10.2210/pdb7a63/pdb |
| Descriptor | Metallo-beta-lactamase L1, ZINC ION, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | metallo-beta-lactamase, antibiotic, faropenem, catalysis, antimicrobial protein |
| Biological source | Stenotrophomonas maltophilia (Pseudomonas maltophilia) |
| Total number of polymer chains | 1 |
| Total formula weight | 29682.37 |
| Authors | Hinchliffe, P.,Spencer, J. (deposition date: 2020-08-24, release date: 2021-02-24, Last modification date: 2024-01-31) |
| Primary citation | Lucic, A.,Hinchliffe, P.,Malla, T.R.,Tooke, C.L.,Brem, J.,Calvopina, K.,Lohans, C.T.,Rabe, P.,McDonough, M.A.,Armistead, T.,Orville, A.M.,Spencer, J.,Schofield, C.J. Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215:113257-113257, 2021 Cited by PubMed: 33618159DOI: 10.1016/j.ejmech.2021.113257 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.57000109226 Å) |
Structure validation
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