6ZYQ

Structure of NDM-1 with 2-Mercaptomethyl-thiazolidine D-syn-1b

Summary for 6ZYQ

• Entry DOI: 10.2210/pdb6zyq/pdb
• Descriptor: Metallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: antibiotic resistance, lactamase, zinc, inhibitor, antimicrobial protein
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 52564.42

Authors

Hinchliffe, P.,Spencer, J. (deposition date: 2020-08-02, release date: 2021-01-20, Last modification date: 2024-01-31)

• Primary citation: Rossi, M.A.,Martinez, V.,Hinchliffe, P.,Mojica, M.F.,Castillo, V.,Moreno, D.M.,Smith, R.,Spellberg, B.,Drusano, G.L.,Banchio, C.,Bonomo, R.A.,Spencer, J.,Vila, A.J.,Mahler, G.; 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases.; Chem Sci, 12:2898-2908, 2021; PubMed: 34164056; DOI: 10.1039/d0sc05172a

Experimental method

X-RAY DIFFRACTION (1.7 Å)