5HH6

Crystal structure of B3 metallo-beta-lactamase L1 in complex with a phosphonate-based inhibitor

Summary for 5HH6

Entry DOI	10.2210/pdb5hh6/pdb
Descriptor	Metallo-beta-lactamase L1, ZINC ION, 6-[(~{S})-oxidanyl(phosphono)methyl]pyridine-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	inhibitor, carbapenamase, pyridine, phosphonate, antibiotic resistance, hydrolase
Biological source	Stenotrophomonas maltophilia (Pseudomonas maltophilia)
Total number of polymer chains	1
Total formula weight	29385.27
Authors	Hinchliffe, P.,Spencer, J. (deposition date: 2016-01-09, release date: 2017-01-18, Last modification date: 2024-01-10)
Primary citation	Hinchliffe, P.,Tanner, C.A.,Krismanich, A.P.,Labbe, G.,Goodfellow, V.J.,Marrone, L.,Desoky, A.Y.,Calvopina, K.,Whittle, E.E.,Zeng, F.,Avison, M.B.,Bols, N.C.,Siemann, S.,Spencer, J.,Dmitrienko, G.I. Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57:1880-1892, 2018 Cited by PubMed: 29485857 DOI: 10.1021/acs.biochem.7b01299 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation