3TS9
 
 | | Crystal Structure of the MDA5 Helicase Insert Domain | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, SULFATE ION | | Authors: | Berke, I.C, Modis, Y. | | Deposit date: | 2011-09-12 | | Release date: | 2012-02-22 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.003 Å) | | Cite: | MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.
Embo J., 31, 2012
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7BKP
 | | CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | | Authors: | Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y. | | Deposit date: | 2021-01-16 | | Release date: | 2021-11-17 | | Last modified: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021
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7BKQ
 | | CryoEM structure of MDA5-dsRNA filament in complex with ADP with 92-degree helical twist | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Isoform 2 of Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), ... | | Authors: | Yu, Q, Modis, Y. | | Deposit date: | 2021-01-17 | | Release date: | 2021-11-17 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021
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6G19
 | | CryoEM structure of the MDA5-dsRNA filament with 74-degree helical twist | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-03-20 | | Release date: | 2018-11-21 | | Last modified: | 2020-11-18 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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6GKM
 | | CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-05-21 | | Release date: | 2018-11-21 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.87 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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7NGA
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6G1X
 | | CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-03-22 | | Release date: | 2018-11-21 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.93 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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6G1S
 | | CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-03-21 | | Release date: | 2018-11-21 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.93 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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6H61
 | | CryoEM structure of the MDA5-dsRNA filament with 89 degree twist and without nucleotide | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-07-25 | | Release date: | 2018-11-21 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.02 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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6GJZ
 | | CryoEM structure of the MDA5-dsRNA filament in complex with AMPPNP | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-05-17 | | Release date: | 2018-11-21 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.06 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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6GKH
 | | CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-05-21 | | Release date: | 2018-11-21 | | Last modified: | 2020-11-18 | | Method: | ELECTRON MICROSCOPY (4.06 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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6H66
 | | CryoEM structure of the MDA5-dsRNA filament with 93 degree twist and without nucleotide | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | | Authors: | Yu, Q, Qu, K, Modis, Y. | | Deposit date: | 2018-07-26 | | Release date: | 2018-11-21 | | Last modified: | 2020-11-18 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Mol. Cell, 72, 2018
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7NIC
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7NIQ
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