3TS9

Crystal Structure of the MDA5 Helicase Insert Domain

Summary for 3TS9

• Entry DOI: 10.2210/pdb3ts9/pdb
• Descriptor: Interferon-induced helicase C domain-containing protein 1, SULFATE ION (3 entities in total)
• Functional Keywords: helix bundle, fancm helicase, super family 2 helicase, sf2 helicase, dexd/h helicase, rig-i-like helicase, antiviral protein, hydrolase
• Biological source: Mus musculus (mouse); More
• Cellular location: Cytoplasm : Q8R5F7
• Total number of polymer chains: 1
• Total formula weight: 16741.95

Authors

Berke, I.C.,Modis, Y. (deposition date: 2011-09-12, release date: 2012-02-22, Last modification date: 2024-02-28)

• Primary citation: Berke, I.C.,Modis, Y.; MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.; Embo J., 31:1714-1726, 2012; PubMed: 22314235; DOI: 10.1038/emboj.2012.19

Experimental method

X-RAY DIFFRACTION (2.003 Å)