5AVW
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![BU of 5avw by Molmil](/molmil-images/mine/5avw) | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 16.5 min | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | Deposit date: | 2015-07-01 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography. Nat Commun, 6, 2015
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5AW8
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![BU of 5aw8 by Molmil](/molmil-images/mine/5aw8) | Kinetics by X-ray crystallography: E2.MgF42-.2RB+ crystal | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | Deposit date: | 2015-07-01 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography. Nat Commun, 6, 2015
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5YLV
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![BU of 5ylv by Molmil](/molmil-images/mine/5ylv) | Crystal structure of the gastric proton pump complexed with SCH28080 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(2-methyl-8-phenylmethoxy-imidazo[1,2-a]pyridin-3-yl)ethanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abe, K, Irie, K, Nakanishi, H, Fujiyoshi, Y. | Deposit date: | 2017-10-19 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.79977775 Å) | Cite: | Crystal structures of the gastric proton pump Nature, 556, 2018
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2DQS
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![BU of 2dqs by Molmil](/molmil-images/mine/2dqs) | |
3TLM
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![BU of 3tlm by Molmil](/molmil-images/mine/3tlm) | Crystal Structure of Endoplasmic Reticulum Ca2+-ATPase (SERCA) From Bovine Muscle | Descriptor: | CALCIUM ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Sacchetto, R, Bertipaglia, I, Giannetti, S, Cendron, L, Mascarello, F, Damiani, E, Carafoli, E, Zanotti, G. | Deposit date: | 2011-08-30 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal structure of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) from bovine muscle. J.Struct.Biol., 178, 2012
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5Y0B
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![BU of 5y0b by Molmil](/molmil-images/mine/5y0b) | PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99 | Descriptor: | Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta | Authors: | Abe, K, Shimokawa, J, Natio, M, Munson, K, Vagin, O, Sachs, G, Suzuki, H, Tani, K, Fujiyoshi, Y. | Deposit date: | 2017-07-16 | Release date: | 2017-08-09 | Method: | ELECTRON CRYSTALLOGRAPHY (6.7 Å) | Cite: | The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors Sci Rep, 7, 2017
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5YLU
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![BU of 5ylu by Molmil](/molmil-images/mine/5ylu) | Crystal structure of the gastric proton pump complexed with vonoprazan | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abe, K, Irie, K, Nakanishi, H, Fujiyoshi, Y. | Deposit date: | 2017-10-19 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.79988956 Å) | Cite: | Crystal structures of the gastric proton pump Nature, 556, 2018
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2EAT
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![BU of 2eat by Molmil](/molmil-images/mine/2eat) | Crystal structure of the SR CA2+-ATPASE with bound CPA and TG | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Takahashi, M, Kondou, Y, Toyoshima, C. | Deposit date: | 2007-02-02 | Release date: | 2007-03-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2EAU
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![BU of 2eau by Molmil](/molmil-images/mine/2eau) | Crystal structure of the SR CA2+-ATPASE with bound CPA in the presence of curcumin | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, PHOSPHATIDYLETHANOLAMINE, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Authors: | Takahashi, M, Kondou, Y, Toyoshima, C. | Deposit date: | 2007-02-02 | Release date: | 2007-03-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2EAR
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![BU of 2ear by Molmil](/molmil-images/mine/2ear) | P21 crystal of the SR CA2+-ATPase with bound TG | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Takahashi, M, Kondou, Y, Toyoshima, C. | Deposit date: | 2007-02-02 | Release date: | 2007-03-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2C88
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![BU of 2c88 by Molmil](/molmil-images/mine/2c88) | Crystal Structure Of (SR) Calcium-ATPase E2(Tg):AMPPCP form | Descriptor: | MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Jensen, A.M, Sorensen, T.L, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-02 | Release date: | 2006-06-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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2C8K
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![BU of 2c8k by Molmil](/molmil-images/mine/2c8k) | Crystal Structure of (SR) Calcium-ATPase E2(Tg) with partially occupied AMPPCP site | Descriptor: | ARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 1, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Jensen, A.M, Sorensen, T.L, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-06 | Release date: | 2006-06-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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2C8L
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![BU of 2c8l by Molmil](/molmil-images/mine/2c8l) | Crystal Structure of (SR) Calcium-ATPase E2(Tg) form | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Jensen, A.M, Sorensen, T.L, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-06 | Release date: | 2006-06-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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5ZTF
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![BU of 5ztf by Molmil](/molmil-images/mine/5ztf) | Structure of Ca2+ ATPase | Descriptor: | CALCIUM ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Inoue, M, Watanabe, S, Inaba, K. | Deposit date: | 2018-05-03 | Release date: | 2019-05-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay. Cell Rep, 27, 2019
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6A69
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![BU of 6a69 by Molmil](/molmil-images/mine/6a69) | Cryo-EM structure of a P-type ATPase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuroplastin, Plasma membrane calcium-transporting ATPase 1 | Authors: | Gong, D.S, Chi, X.M, Ren, K, Huang, G.X.Y, Zhou, G.W, Yan, N, Lei, J.L, Zhou, Q. | Deposit date: | 2018-06-27 | Release date: | 2018-09-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.11 Å) | Cite: | Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin. Nat Commun, 9, 2018
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3KDP
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![BU of 3kdp by Molmil](/molmil-images/mine/3kdp) | Crystal structure of the sodium-potassium pump | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, ... | Authors: | Morth, J.P, Pedersen, B.P, Nissen, P. | Deposit date: | 2009-10-23 | Release date: | 2010-02-16 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the sodium-potassium pump. Nature, 450, 2007
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3N5K
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![BU of 3n5k by Molmil](/molmil-images/mine/3n5k) | Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form | Descriptor: | ACETATE ION, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Bublitz, M, Olesen, C, Poulsen, H, Morth, J.P, Moller, J.V, Nissen, P. | Deposit date: | 2010-05-25 | Release date: | 2011-06-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Ion pathways in the sarcoplasmic reticulum Ca2+-ATPase. J.Biol.Chem., 288, 2013
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3N23
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![BU of 3n23 by Molmil](/molmil-images/mine/3n23) | Crystal structure of the high affinity complex between ouabain and the E2P form of the sodium-potassium pump | Descriptor: | MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, OUABAIN, ... | Authors: | Yatime, L, Laursen, M, Morth, J.P, Esmann, M, Nissen, P, Fedosova, N.U. | Deposit date: | 2010-05-17 | Release date: | 2011-01-19 | Last modified: | 2014-09-17 | Method: | X-RAY DIFFRACTION (4.6 Å) | Cite: | Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase. J.Struct.Biol., 174, 2011
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3W5C
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![BU of 3w5c by Molmil](/molmil-images/mine/3w5c) | Crystal structure of the calcium pump in the E2 state free from exogenous inhibitors | Descriptor: | PHOSPHATIDYLETHANOLAMINE, SERCA1a, SODIUM ION | Authors: | Toyoshima, C, Iwasawa, S, Ogawa, H, Hirata, A, Tsueda, J, Inesi, G. | Deposit date: | 2013-01-27 | Release date: | 2013-03-06 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state. Nature, 495, 2013
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3WGV
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![BU of 3wgv by Molmil](/molmil-images/mine/3wgv) | Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state with oligomycin | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Kanai, R, Ogawa, H, Vilsen, B, Cornelius, F, Toyoshima, C. | Deposit date: | 2013-08-09 | Release date: | 2013-10-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state Nature, 502, 2013
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5ZMV
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![BU of 5zmv by Molmil](/molmil-images/mine/5zmv) | Crystal structure of the E309A mutant of SR Ca2+-ATPase in E2(TG) | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Ogawa, H, Hirata, A, Tsueda, J, Toyoshima, C. | Deposit date: | 2018-04-06 | Release date: | 2018-12-12 | Last modified: | 2018-12-26 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Mechanism of the E2 to E1 transition in Ca2+pump revealed by crystal structures of gating residue mutants. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3NAN
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![BU of 3nan by Molmil](/molmil-images/mine/3nan) | SR Ca(2+)-ATPase in the HnE2 state complexed with a Thapsigargin derivative Boc-(phi)Tg | Descriptor: | (3S,3aR,4S,6S,6aR,7S,8S,9R,9aS,9bS)-6-(acetyloxy)-4-{[4-(3-{6-[(tert-butoxycarbonyl)amino]hexyl}-4-hydroxyphenyl)butanoyl]oxy}-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxododecahydroazuleno[4,5-b]furan-7-yl octanoate, MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... | Authors: | Winther, A.M.L, Sonntag, Y, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2010-06-02 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs J.Biol.Chem., 285, 2010
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5ZMW
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![BU of 5zmw by Molmil](/molmil-images/mine/5zmw) | Crystal structure of the E309Q mutant of SR Ca2+-ATPase in E2(TG) | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Ogawa, H, Hirata, A, Tsueda, J, Toyoshima, C. | Deposit date: | 2018-04-06 | Release date: | 2019-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism of the E2 to E1 transition in Ca2+pump revealed by crystal structures of gating residue mutants. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3W5B
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![BU of 3w5b by Molmil](/molmil-images/mine/3w5b) | Crystal structure of the recombinant SERCA1a (calcium pump of fast twitch skeletal muscle) in the E1.Mg2+ state | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... | Authors: | Toyoshima, C, Iwasawa, S, Ogawa, H, Hirata, A, Tsueda, J, Inesi, G. | Deposit date: | 2013-01-27 | Release date: | 2013-03-06 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state. Nature, 495, 2013
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3NAL
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![BU of 3nal by Molmil](/molmil-images/mine/3nal) | SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative DTB | Descriptor: | (3S,3aR,4S,6S,6aS,8R,9bS)-6-(acetyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-4-yl dodecanoate, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Winther, A.M.L, Sonntag, Y, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2010-06-02 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs J.Biol.Chem., 285, 2010
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