3N23

Crystal structure of the high affinity complex between ouabain and the E2P form of the sodium-potassium pump

Summary for 3N23

Entry DOI	10.2210/pdb3n23/pdb
Related	3B9B 3KDP 3N2F
Descriptor	Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1, Na+/K+ ATPase gamma subunit transcript variant a, ... (5 entities in total)
Functional Keywords	sodium-potassium pump, p-type atpase, ouabain, cardiotonic steroids, hydrolase
Biological source	Sus scrofa (pigs) More
Cellular location	Cell membrane; Multi-pass membrane protein: P05024 Cell membrane; Single-pass type II membrane protein: P05027
Total number of polymer chains	6
Total formula weight	291749.44
Authors	Yatime, L.,Laursen, M.,Morth, J.P.,Esmann, M.,Nissen, P.,Fedosova, N.U. (deposition date: 2010-05-17, release date: 2011-01-19, Last modification date: 2014-09-17)
Primary citation	Yatime, L.,Laursen, M.,Morth, J.P.,Esmann, M.,Nissen, P.,Fedosova, N.U. Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase. J.Struct.Biol., 174:296-306, 2011 Cited by PubMed: 21182963 DOI: 10.1016/j.jsb.2010.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.6 Å)

Structure validation