7W49

Crystal structure of the gastric proton pump complexed with soraprazan

Summary for 7W49

• Entry DOI: 10.2210/pdb7w49/pdb
• Descriptor: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: cation pump, p-type atpase, gastric, proton pump, membrane protein, p-cab, hydrolase
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 2
• Total formula weight: 148796.88

Authors

Abe, K.,Tanaka, S. (deposition date: 2021-11-26, release date: 2022-01-05, Last modification date: 2023-11-29)

• Primary citation: Tanaka, S.,Morita, M.,Yamagishi, T.,Madapally, H.V.,Hayashida, K.,Khandelia, H.,Gerle, C.,Shigematsu, H.,Oshima, A.,Abe, K.; Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.; J.Med.Chem., 65:7843-7853, 2022; PubMed: 35604136; DOI: 10.1021/acs.jmedchem.2c00338

Experimental method

X-RAY DIFFRACTION (3.1 Å)