7W49
Crystal structure of the gastric proton pump complexed with soraprazan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Potassium-transporting ATPase alpha chain 1 | polymer | 1034 | 114456.7 | 1 | UniProt (P19156) Pfam (PF09040) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00702) Pfam (PF00689) In PDB | Sus scrofa (Pig) | Gastric H(+)/K(+) ATPase subunit alpha,Proton pump |
| 2 | B | Potassium-transporting ATPase subunit beta | polymer | 290 | 33113.8 | 1 | UniProt (P18434) Pfam (PF00287) In PDB | Sus scrofa (Pig) | Gastric H(+)/K(+) ATPase subunit beta,Proton pump beta chain,gp60-90 |
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | RUBIDIUM ION | non-polymer | 85.5 | 2 | Chemie (RB) | |||
| 5 | A | Soraprazan | non-polymer | 367.4 | 1 | Chemie (8CE) | |||
| 6 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: 0 - 1033 (UniProt: P19156)
| PDB | External Database | Details |
|---|---|---|
| Cys 220 | Arg 221 | engineered mutation |
| Cys 593 | Ser 594 | engineered mutation |
| Ser 1005 | Gly 1006 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 147570.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1226.3 | |
| All* | Total formula weight | 148796.9 |
