7OLC
| Thermophilic eukaryotic 80S ribosome at idle POST state | Descriptor: | 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... | Authors: | Kisonaite, M, Wild, K, Sinning, I. | Deposit date: | 2021-05-19 | Release date: | 2022-01-26 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation. Nat Commun, 13, 2022
|
|
8PV8
| Chaetomium thermophilum pre-60S State 4 - post-5S rotation with Rix1 complex without Foot - composite structure | Descriptor: | 26S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. | Deposit date: | 2023-07-17 | Release date: | 2024-01-10 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
|
|
4U4Q
| Crystal structure of Homoharringtonine bound to the yeast 80S ribosome | Descriptor: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S ribosomal RNA, 25S ribosomal RNA, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
|
|
4U3M
| Crystal structure of Anisomycin bound to the yeast 80S ribosome | Descriptor: | 18S rRNA, 25s rRNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-22 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
|
|
4U4U
| Crystal structure of Lycorine bound to the yeast 80S ribosome | Descriptor: | (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 18S ribosomal RNA, 25S ribosomal RNA, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
|
|
4V88
| The structure of the eukaryotic ribosome at 3.0 A resolution. | Descriptor: | 18S RIBOSOMAL RNA, 18S rRNA, 25S rRNA, ... | Authors: | Ben-Shem, A, Garreau de Loubresse, N, Melnikov, S, Jenner, L, Yusupova, G, Yusupov, M. | Deposit date: | 2011-10-11 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structure of the eukaryotic ribosome at 3.0 angstrom resolution. Science, 334, 2011
|
|
7OLD
| Thermophilic eukaryotic 80S ribosome at pe/E (TI)-POST state | Descriptor: | 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... | Authors: | Kisonaite, M, Wild, K, Sinning, I. | Deposit date: | 2021-05-19 | Release date: | 2022-01-26 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation. Nat Commun, 13, 2022
|
|
5TBW
| Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Konst, Z.A, Szklarski, A.R, Pellegrino, S, Michalak, S.E, Meyer, M, Zanette, C, Cencic, R, Nam, S, Horne, D.A, Pelletier, J, Mobley, D.L, Yusupova, G, Yusupov, M, Vanderwal, C.D. | Deposit date: | 2016-09-13 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides. Nat Chem, 9, 2017
|
|
8K82
| Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA | Descriptor: | 18S rRNA, 23S rRNA, 40S ribosomal protein S1-A, ... | Authors: | Buschauer, R, Beckmann, R, Cheng, J. | Deposit date: | 2023-07-28 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
8CAH
| Cryo-EM structure of native Otu2-bound ubiquitinated 43S pre-initiation complex | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | Authors: | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2023-01-24 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun, 14, 2023
|
|
6FYY
| Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2) | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | Authors: | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2018-03-12 | Release date: | 2018-12-05 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. Elife, 7, 2018
|
|
7MPI
| Stm1 bound vacant 80S structure isolated from cbf5-D95A | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Rai, J, Zhao, Y, Li, H. | Deposit date: | 2021-05-04 | Release date: | 2022-05-11 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations. Structure, 30, 2022
|
|
7N8B
| Cycloheximide bound vacant 80S structure isolated from cbf5-D95A | Descriptor: | 18S RIBOSOMAL RNA, 25S, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Rai, J, Zhao, Y, Li, H. | Deposit date: | 2021-06-14 | Release date: | 2022-05-11 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations. Structure, 30, 2022
|
|
4U4N
| Crystal structure of Edeine bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
|
|
4U4Z
| Crystal structure of Phyllanthoside bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
|
|
5FCJ
| Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M. | Deposit date: | 2015-12-15 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency. J.Mol.Biol., 428, 2016
|
|
8BIP
| Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Knorr, A.G, Mackens-Kiani, T, Musial, J, Berninghausen, O, Becker, T, Beatrix, B, Beckmann, R. | Deposit date: | 2022-11-02 | Release date: | 2023-02-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains. Plos Biol., 21, 2023
|
|
5I4L
| Crystal structure of Amicoumacin A bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Prokhorova, I.V, Yusupova, G, Yusupov, M. | Deposit date: | 2016-02-12 | Release date: | 2016-06-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome. Sci Rep, 6, 2016
|
|
6T7T
| Structure of yeast 80S ribosome stalled on poly(A) tract. | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R. | Deposit date: | 2019-10-23 | Release date: | 2019-12-25 | Last modified: | 2020-02-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts. Embo J., 39, 2020
|
|
6TNU
| Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs. | Descriptor: | 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Buschauer, R, Cheng, J, Berninghausen, O, Tesina, P, Becker, T, Beckmann, R. | Deposit date: | 2019-12-10 | Release date: | 2020-04-22 | Last modified: | 2020-04-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The Ccr4-Not complex monitors the translating ribosome for codon optimality. Science, 368, 2020
|
|
5DGV
| Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog | Descriptor: | 25S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-28 | Release date: | 2016-12-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
|
|
8OO0
| Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S0, ... | Authors: | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | Deposit date: | 2023-04-04 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome. Nat Commun, 15, 2024
|
|
5ON6
| Crystal structure of haemanthamine bound to the 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Pellegrino, S, Meyer, M, Yusupova, G, Yusupov, M. | Deposit date: | 2017-08-03 | Release date: | 2018-02-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.10000229 Å) | Cite: | The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure, 26, 2018
|
|
5DAT
| Complex of yeast 80S ribosome with hypusine-containing eIF5A | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-20 | Release date: | 2016-08-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
|
|
8P4V
| 80S yeast ribosome in complex with HaterumaimideQ | Descriptor: | (3~{R})-3-[(1~{S})-2-[(1~{R},3~{S},4~{a}~{S},8~{a}~{S})-5,5,8~{a}-trimethyl-2-methylidene-3-oxidanyl-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione, 18S ribosomal RNA, 25S ribosomal RNA, ... | Authors: | Terrosu, S, Yusupov, M. | Deposit date: | 2023-05-23 | Release date: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Role of Protein eL42 in the Ribosome Binding of Synthetic Analogues of Natural Lissoclimides To Be Published
|
|