8TNR
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![BU of 8tnr by Molmil](/molmil-images/mine/8tnr) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 | Descriptor: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | Authors: | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | Deposit date: | 2023-08-02 | Release date: | 2024-03-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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7JTR
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![BU of 7jtr by Molmil](/molmil-images/mine/7jtr) | Complex of maltose-binding protein (MBP) with single-chain Fv (scFv) | Descriptor: | CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Loll, P.J. | Deposit date: | 2020-08-18 | Release date: | 2021-05-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A useful epitope tag derived from maltose binding protein. Protein Sci., 30, 2021
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3A3C
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![BU of 3a3c by Molmil](/molmil-images/mine/3a3c) | Crystal structure of TIM40/MIA40 fusing MBP, C296S and C298S mutant | Descriptor: | Maltose-binding periplasmic protein, LINKER, Mitochondrial intermembrane space import and assembly protein 40, ... | Authors: | Kawano, S, Naoe, M, Momose, T, Watanabe, N, Endo, T. | Deposit date: | 2009-06-11 | Release date: | 2009-08-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space. Proc.Natl.Acad.Sci.USA, 106, 2009
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6YBJ
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![BU of 6ybj by Molmil](/molmil-images/mine/6ybj) | Structure of MBP-Mcl-1 in complex with compound 3e | Descriptor: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[(2-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, ... | Authors: | Dokurno, P, Surgenor, A.E, Murray, J.B. | Deposit date: | 2020-03-17 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J.Med.Chem., 63, 2020
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1JVX
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![BU of 1jvx by Molmil](/molmil-images/mine/1jvx) | Maltodextrin-binding protein variant D207C/A301GS/P316C cross-linked in crystal | Descriptor: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltodextrin-binding protein | Authors: | Srinivasan, U, Iyer, G.H, Przybycien, T.A, Samsonoff, W.A, Bell, J.A. | Deposit date: | 2001-08-31 | Release date: | 2001-09-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystine: Fibrous Biomolecular Material from Protein Crystals Cross-linked in a Specific Geometry Protein Eng., 15, 2002
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5YEV
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![BU of 5yev by Molmil](/molmil-images/mine/5yev) | Murine DR3 death domain | Descriptor: | SULFATE ION, TNFRSF25 death domain | Authors: | Yin, X, Jin, T. | Deposit date: | 2017-09-19 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure and activation mechanism of DR3 death domain. Febs J., 286, 2019
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6N85
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![BU of 6n85 by Molmil](/molmil-images/mine/6n85) | Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350 | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Guanine nucleotide-binding protein G(t) subunit alpha-2, Synembryn-A, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Srivastava, D, Gakhar, L, Artemyev, N.O. | Deposit date: | 2018-11-28 | Release date: | 2019-07-10 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor. Nat Commun, 10, 2019
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3N93
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![BU of 3n93 by Molmil](/molmil-images/mine/3n93) | Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 3 | Descriptor: | GLYCEROL, Maltose binding protein-CRFR2 alpha, Urocortin-3, ... | Authors: | Pal, K, Swaminathan, K, Pioszak, A.A, Xu, H.E. | Deposit date: | 2010-05-28 | Release date: | 2010-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain To be Published
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1N3X
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![BU of 1n3x by Molmil](/molmil-images/mine/1n3x) | Ligand-free High-Affinity Maltose-Binding Protein | Descriptor: | Maltose-binding periplasmic protein | Authors: | Telmer, P.G, Shilton, B.H. | Deposit date: | 2002-10-29 | Release date: | 2003-08-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insights into the Conformational Equilibria of Maltose-binding Protein by Analysis of High Affinity Mutants. J.Biol.Chem., 278, 2003
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4ZBI
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![BU of 4zbi by Molmil](/molmil-images/mine/4zbi) | Mcl-1 complexed with small molecules | Descriptor: | 1-[3-(naphthalen-1-yloxy)propyl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Zhao, B. | Deposit date: | 2015-04-14 | Release date: | 2015-04-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. J.Med.Chem., 58, 2015
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1ZMG
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![BU of 1zmg by Molmil](/molmil-images/mine/1zmg) | |
4N4X
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![BU of 4n4x by Molmil](/molmil-images/mine/4n4x) | Crystal Structure of the MBP fused human SPLUNC1 (native form) | Descriptor: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, Maltose-binding periplasmic/Palate lung and nasal epithelium clone fusion protein | Authors: | Ning, F, Wang, C, Niu, L, Chu, H.W, Zhang, G. | Deposit date: | 2013-10-08 | Release date: | 2014-09-17 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Lipid ligands of human SPLUNC1 To be Published
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7RW6
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![BU of 7rw6 by Molmil](/molmil-images/mine/7rw6) | BORF2-APOBEC3Bctd Complex | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION | Authors: | Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S. | Deposit date: | 2021-08-19 | Release date: | 2022-04-27 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. Sci Adv, 8, 2022
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7MHW
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![BU of 7mhw by Molmil](/molmil-images/mine/7mhw) | Crystal structure of the protease inhibitor U-Omp19 from Brucella abortus fused to Maltose-binding protein | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Outer membrane lipoprotein omp19, SULFATE ION | Authors: | Darriba, M.L, Klinke, S, Otero, L.H, Cerutti, M.L, Cassataro, J, Pasquevich, K.A. | Deposit date: | 2021-04-15 | Release date: | 2022-04-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A disordered region retains the full protease inhibitor activity and the capacity to induce CD8 + T cells in vivo of the oral vaccine adjuvant U-Omp19. Comput Struct Biotechnol J, 20, 2022
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6U64
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![BU of 6u64 by Molmil](/molmil-images/mine/6u64) | Mcl-1 bound to compound 17 | Descriptor: | 5-[(2-phenylethyl)sulfanyl]-2-{[(4-phenylpiperazin-1-yl)sulfonyl]amino}benzoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Stuckey, J.A. | Deposit date: | 2019-08-29 | Release date: | 2020-03-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. J.Med.Chem., 63, 2020
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6D67
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![BU of 6d67 by Molmil](/molmil-images/mine/6d67) | Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion (maltose bound form) in complex with the designed AR protein mbp3_16 | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Designed AR protein mbp3_16, ... | Authors: | Gumpena, R, Lountos, G.T, Waugh, D.S. | Deposit date: | 2018-04-20 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
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4GIZ
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![BU of 4giz by Molmil](/molmil-images/mine/4giz) | Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution | Descriptor: | Maltose-binding periplasmic protein, UBIQUITIN LIGASE EA6P: chimeric protein, Protein E6, ... | Authors: | McEwen, A.G, Zanier, K, Charbonnier, S, Poussin, P, Cura, V, Vande Pol, S, Trave, G, Cavarelli, J. | Deposit date: | 2012-08-09 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science, 339, 2013
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6FS2
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![BU of 6fs2 by Molmil](/molmil-images/mine/6fs2) | MCL1 in complex with indole acid ligand | Descriptor: | 7-(2-methylphenyl)-3-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl]-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Hargreaves, D. | Deposit date: | 2018-02-18 | Release date: | 2018-12-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun, 9, 2018
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5ZNZ
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![BU of 5znz by Molmil](/molmil-images/mine/5znz) | Structure of mDR3 DD with MBP tag mutant-I387V | Descriptor: | Maltose-binding periplasmic protein,Tumor necrosis factor receptor superfamily, member 25, SULFATE ION | Authors: | Jin, T, Yin, X. | Deposit date: | 2018-04-12 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structure and activation mechanism of DR3 death domain. Febs J., 286, 2019
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5AZ6
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![BU of 5az6 by Molmil](/molmil-images/mine/5az6) | |
3MP1
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![BU of 3mp1 by Molmil](/molmil-images/mine/3mp1) | Complex structure of Sgf29 and trimethylated H3K4 | Descriptor: | ACETATE ION, H3K4me3 peptide, Maltose-binding periplasmic protein,LINKER,SAGA-associated factor 29, ... | Authors: | Li, J, Ruan, J, Wu, M, Xue, X, Zang, J. | Deposit date: | 2010-04-24 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J., 30, 2011
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5IEZ
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![BU of 5iez by Molmil](/molmil-images/mine/5iez) | Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) inhibitors using Structure-Based Design | Descriptor: | 3-({6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-2-carbonyl}amino)benzoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Zhao, B. | Deposit date: | 2016-02-25 | Release date: | 2017-01-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors. FEBS Lett., 591, 2017
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8C5L
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![BU of 8c5l by Molmil](/molmil-images/mine/8c5l) | |
8J25
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![BU of 8j25 by Molmil](/molmil-images/mine/8j25) | Crystal structure of PML B-box2 mutant | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Protein PML, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Zhou, C, Zang, N, Zhang, J. | Deposit date: | 2023-04-14 | Release date: | 2023-09-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function. Cancer Discov, 13, 2023
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1PEB
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![BU of 1peb by Molmil](/molmil-images/mine/1peb) | LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN | Descriptor: | Maltose-binding periplasmic protein | Authors: | Telmer, P.G, Shilton, B.H. | Deposit date: | 2003-05-21 | Release date: | 2003-08-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insights into the Conformational Equilibria of Maltose-binding Protein by Analysis of High Affinity Mutants. J.Biol.Chem., 278, 2003
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