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PDB: 1112 results
2X7T
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BU of 2x7t by Molmil
Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
Descriptor: (9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL DISULFAMATE, CARBONIC ANHYDRASE 2, GLYCEROL, ...
Authors:Cozier, G.E, Leese, M.P, Lloyd, M.D, Baker, M.D, Thiyagarajan, N, Acharya, K.R, Potter, B.V.L.
Deposit date:2010-03-03
Release date:2010-03-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structures of Human Carbonic Anhydrase II/Inhibitor Complexes Reveal a Second Binding Site for Steroidal and Non-Steroidal Inhibitors.
Biochemistry, 49, 2010
5JMZ
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BU of 5jmz by Molmil
Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2
Descriptor: 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ...
Authors:McKenna, R, Mboge, M.Y, Mahon, B.P.
Deposit date:2016-04-29
Release date:2017-05-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2
To Be Published
8EXC
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BU of 8exc by Molmil
Human Carbonic Anhydrase II bound tert-butyl (3-(4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)butoxy)propyl)carbamate
Descriptor: Carbonic anhydrase 2, MERCURIBENZOIC ACID, N-(3-{4-[3-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}amino)propoxy]butoxy}propyl)-4-sulfamoylbenzamide, ...
Authors:Kohlbrand, A.J, O'Herin, C.B.
Deposit date:2022-10-25
Release date:2023-02-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of Human Carbonic Anhydrase II Heterobifunctional Degraders.
J.Med.Chem., 2023
3F4X
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BU of 3f4x by Molmil
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference
Descriptor: 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Carbonic anhydrase 2, MERCURY (II) ION, ...
Authors:Temperini, C, Cecchi, A, Scozzafava, A, Supuran, C.T.
Deposit date:2008-11-03
Release date:2009-03-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.
J.Med.Chem., 52, 2009
1RZC
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BU of 1rzc by Molmil
X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
Descriptor: CARBONIC ANHYDRASE II, COPPER (II) ION, OXYGEN MOLECULE
Authors:Hakansson, K, Wehnert, A, Liljas, A.
Deposit date:1993-05-25
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.
Acta Crystallogr.,Sect.D, 50, 1994
3BL0
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BU of 3bl0 by Molmil
Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
Descriptor: 1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Temperini, C, Supuran, C.T, Blackburn, G.M.
Deposit date:2007-12-10
Release date:2008-01-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorg.Med.Chem.Lett., 18, 2008
2HKK
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BU of 2hkk by Molmil
Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms
Descriptor: Carbonic anhydrase 2, L-EPINEPHRINE, MERCURY (II) ION, ...
Authors:Temperini, C, Innocenti, A, Vullo, D, Scozzafava, A, Supuran, C.T.
Deposit date:2006-07-05
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.
Bioorg.Med.Chem.Lett., 17, 2007
1BCD
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BU of 1bcd by Molmil
X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE
Descriptor: CARBONIC ANHYDRASE II, TRIFLUOROMETHANE SULFONAMIDE, ZINC ION
Authors:Hakansson, K, Liljas, A.
Deposit date:1993-08-31
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide.
FEBS Lett., 350, 1994
1CAK
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BU of 1cak by Molmil
STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S.
Deposit date:1992-09-17
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.
Proteins, 17, 1993
1RZE
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BU of 1rze by Molmil
X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
Descriptor: CARBONIC ANHYDRASE II, NICKEL (II) ION, SULFATE ION
Authors:Hakansson, K, Wehnert, A, Liljas, A.
Deposit date:1993-05-25
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.
Acta Crystallogr.,Sect.D, 50, 1994
1CAJ
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BU of 1caj by Molmil
STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S.
Deposit date:1992-09-17
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.
Proteins, 17, 1993
1CAO
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BU of 1cao by Molmil
CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
Descriptor: CARBONIC ANHYDRASE II, HYDROSULFURIC ACID, ZINC ION
Authors:Mangani, S, Hakansson, K.
Deposit date:1992-07-02
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions.
Eur.J.Biochem., 210, 1992
1CAN
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BU of 1can by Molmil
CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, NITRATE ION
Authors:Mangani, S, Hakansson, K.
Deposit date:1992-07-02
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions.
Eur.J.Biochem., 210, 1992
1CAZ
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BU of 1caz by Molmil
WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
Descriptor: ACETIC ACID, CARBONIC ANHYDRASE II, ZINC ION
Authors:Hakansson, K, Briand, C, Zaitsev, V, Xue, Y, Liljas, A.
Deposit date:1993-02-26
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Wild-type and E106Q mutant carbonic anhydrase complexed with acetate.
Acta Crystallogr.,Sect.D, 50, 1994
3DD8
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BU of 3dd8 by Molmil
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
Descriptor: 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate, Carbonic anhydrase 2, MERCURY (II) ION, ...
Authors:Temperini, C, Innocenti, A, Scozzafava, A, Supuran, C.T.
Deposit date:2008-06-05
Release date:2008-08-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies
Bioorg.Med.Chem.Lett., 18, 2008
1RAZ
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BU of 1raz by Molmil
THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
Descriptor: BROMIDE ION, CARBONIC ANHYDRASE II, ZINC ION
Authors:Jonsson, B.M, Hakansson, K, Liljas, A.
Deposit date:1993-04-02
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure of human carbonic anhydrase II in complex with bromide and azide.
FEBS Lett., 322, 1993
4JSW
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BU of 4jsw by Molmil
Human carbonic anhydrase II H94C
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Martin, D.P, Hann, Z.S, Cohen, S.M.
Deposit date:2013-03-22
Release date:2013-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
2H4N
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BU of 2h4n by Molmil
H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1997-05-29
Release date:1997-09-17
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Biochemistry, 36, 1997
1CRA
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BU of 1cra by Molmil
THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE
Descriptor: 1,2,4-TRIAZOLE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Mangani, S, Liljas, A.
Deposit date:1992-10-21
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole.
J.Mol.Biol., 232, 1993
1RZA
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BU of 1rza by Molmil
X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
Descriptor: CARBONIC ANHYDRASE II, COBALT (II) ION, OXYGEN MOLECULE
Authors:Hakansson, K, Wehnert, A, Liljas, A.
Deposit date:1993-05-25
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.
Acta Crystallogr.,Sect.D, 50, 1994
1CNX
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BU of 1cnx by Molmil
SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
Descriptor: AMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Boriack, P.A, Christianson, D.W.
Deposit date:1995-07-21
Release date:1995-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
J.Med.Chem., 38, 1995
4JSZ
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BU of 4jsz by Molmil
Benzenesulfonamide bound to hCAII H94C
Descriptor: Carbonic anhydrase 2, ZINC ION, benzenesulfonamide
Authors:Martin, D.P, Hann, Z.S, Cohen, S.M.
Deposit date:2013-03-22
Release date:2013-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
1RZD
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BU of 1rzd by Molmil
X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
Descriptor: CARBONIC ANHYDRASE II, MANGANESE (II) ION, SULFATE ION
Authors:Hakansson, K, Wehnert, A, Liljas, A.
Deposit date:1993-05-25
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.
Acta Crystallogr.,Sect.D, 50, 1994
1F2W
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BU of 1f2w by Molmil
THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, CARBONIC ANHYDRASE II, CYANAMIDE, ...
Authors:Guerri, A, Briganti, F, Scozzafava, A, Supuran, C.T, Mangani, S.
Deposit date:2000-05-30
Release date:2000-06-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction.
Biochemistry, 39, 2000
3K7K
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BU of 3k7k by Molmil
Crystal structure of the complex between Carbonic Anhydrase II and anions
Descriptor: Carbonic anhydrase 2, MERCURY (II) ION, ZINC ION, ...
Authors:Temperini, C.
Deposit date:2009-10-13
Release date:2010-01-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct-An inhibitor mimicking the sulfonamide and urea binding to the enzyme
Bioorg.Med.Chem.Lett., 20, 2010

223532

건을2024-08-07부터공개중

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