5O40
 
 | | SOD1 bound to Ebselen | | 分子名称: | N-phenyl-2-selanylbenzamide, SULFATE ION, Superoxide dismutase [Cu-Zn], ... | | 著者 | Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S. | | 登録日 | 2017-05-25 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Nat Commun, 9, 2018
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5O3Y
 | | SOD1 bound to Ebsulfur | | 分子名称: | SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION, ... | | 著者 | Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S. | | 登録日 | 2017-05-25 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Nat Commun, 9, 2018
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8K3L
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8K3A
 | | SOD1 and Nanobody2 complex | | 分子名称: | NB2, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Cheng, S. | | 登録日 | 2023-07-14 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | SOD1 and Nanobody1 complex
To Be Published
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8K33
 | | SOD1 and Nanobody1 complex | | 分子名称: | NB1, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Cheng, S. | | 登録日 | 2023-07-14 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | SOD1 and Nanobody1 complex
To Be Published
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3LTV
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3CQP
 | | Human SOD1 G85R Variant, Structure I | | 分子名称: | COPPER (II) ION, MALONATE ION, Superoxide dismutase [Cu-Zn], ... | | 著者 | Cao, X, Antonyuk, S, Seetharaman, S.V, Whitson, L.J, Taylor, A.B, Holloway, S.P, Strange, R.W, Doucette, P.A, Valentine, J.S, Tiwari, A, Hayward, L.J, Padua, S, Cohlberg, J.A, Hasnain, S.S, Hart, P.J. | | 登録日 | 2008-04-03 | | 公開日 | 2008-04-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis.
J.Biol.Chem., 283, 2008
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8CCX
 | | Human SOD1 in complex with S-XL6 cross-linker | | 分子名称: | COPPER (II) ION, DIMETHYL SULFOXIDE, SULFATE ION, ... | | 著者 | Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S. | | 登録日 | 2023-01-27 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.665 Å) | | 主引用文献 | Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
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6A9O
 | | Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis | | 分子名称: | 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid, DIMETHYL SULFOXIDE, Dihydrogen tetrasulfide, ... | | 著者 | Manjula, R, Padmanabhan, B. | | 登録日 | 2018-07-14 | | 公開日 | 2019-07-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.
J.Biomol.Struct.Dyn., 37, 2019
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8Q6M
 | | Human SOD1 low dose data collecton | | 分子名称: | ACETATE ION, COPPER (II) ION, SULFATE ION, ... | | 著者 | Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S. | | 登録日 | 2023-08-14 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
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3QQD
 | | Human SOD1 H80R variant, P212121 crystal form | | 分子名称: | SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Seetharaman, S.V, Winkler, D.D, Taylor, A.B, Cao, X, Whitson, L.J, Doucette, P.A, Valentine, J.S, Schirf, V, Demeler, B, Carroll, M.C, Culotta, V.C, Hart, P.J. | | 登録日 | 2011-02-15 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.653 Å) | | 主引用文献 | Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.
Biochemistry, 49, 2010
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2NAM
 | | Full-length WT SOD1 in DPC MICELLE | | 分子名称: | Superoxide dismutase [Cu-Zn] | | 著者 | Lim, L, Song, J. | | 登録日 | 2016-01-06 | | 公開日 | 2016-12-14 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | SALS-linked WT-SOD1 adopts a highly similar helical conformation as FALS-causing L126Z-SOD1 in a membrane environment
Biochim.Biophys.Acta, 1858, 2016
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5DLI
 | | Corkscrew assembly of SOD1 residues 28-38 | | 分子名称: | GLYCEROL, IODIDE ION, Superoxide dismutase [Cu-Zn] | | 著者 | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | | 登録日 | 2015-09-05 | | 公開日 | 2016-09-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2MP3
 | | Truncated L126Z-sod1 in DPC micelle | | 分子名称: | Superoxide dismutase [Cu-Zn] | | 著者 | Lim, L, Song, J. | | 登録日 | 2014-05-10 | | 公開日 | 2015-05-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations
Biochim.Biophys.Acta, 1848, 2015
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6B79
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3CQQ
 | | Human SOD1 G85R Variant, Structure II | | 分子名称: | ACETYL GROUP, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Cao, X, Antonyuk, S, Whitson, L.J, Taylor, A.B, Holloway, S.P, Strange, R.W, Doucette, P.A, Valentine, J.S, Tiwari, A, Hayward, L.J, Padua, S, Cohlberg, J.A, Hasnain, S.S, Hart, P.J. | | 登録日 | 2008-04-03 | | 公開日 | 2008-04-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis.
J.Biol.Chem., 283, 2008
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5K02
 | | Structure of human SOD1 with T2D mutation | | 分子名称: | COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Fay, J.M, Zhu, C, Cui, W, Ke, H, Dokholyan, N.V. | | 登録日 | 2016-05-17 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation.
Structure, 24, 2016
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7VZF
 | | Cryo-EM structure of amyloid fibril formed by full-length human SOD1 | | 分子名称: | Superoxide dismutase [Cu-Zn] | | 著者 | Wang, L.Q, Ma, Y.Y, Yuan, H.Y, Zhao, K, Zhang, M.Y, Wang, Q, Huang, X, Xu, W.C, Chen, J, Li, D, Zhang, D.L, Zou, L.Y, Yin, P, Liu, C, Liang, Y. | | 登録日 | 2021-11-16 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion.
Nat Commun, 13, 2022
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5YTU
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6FON
 | | Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 | | 分子名称: | Copper chaperone for superoxide dismutase, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Wright, G.S.A, Sala, F.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. | | 登録日 | 2018-02-07 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.
Plos Biol., 17, 2019
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6FP6
 | | Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation | | 分子名称: | Copper chaperone for superoxide dismutase, GLYCEROL, PROPANOIC ACID, ... | | 著者 | Sala, F.A, Wright, G.S.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. | | 登録日 | 2018-02-09 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.
Plos Biol., 17, 2019
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6FOI
 | | Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. | | 分子名称: | SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION | | 著者 | Wright, G.S.A, Sala, F.A, Antonyuk, S.V, Garratt, R.C, Hasnain, S.S. | | 登録日 | 2018-02-07 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.
Plos Biol., 17, 2019
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5YTO
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5YUL
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6FLH
 | | Monomeric Human Cu,Zn Superoxide dismutase, SOD1 7+7, apo form | | 分子名称: | GLYCEROL, SULFATE ION, Superoxide dismutase [Cu-Zn] | | 著者 | Wang, H, Yang, F, Logan, D, Oliveberg, M. | | 登録日 | 2018-01-25 | | 公開日 | 2018-11-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | The Cost of Long Catalytic Loops in Folding and Stability of the ALS-Associated Protein SOD1.
J.Am.Chem.Soc., 140, 2018
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