3UND
 
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2QKF
 | | Crystal structure of 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | | 分子名称: | 3-deoxy-D-manno-octulosonic acid 8- phosphate synthetase, CHLORIDE ION, GLYCEROL, ... | | 著者 | Cochrane, F.C, Patchett, M.L, Jameson, G.B, Parker, E.J. | | 登録日 | 2007-07-11 | | 公開日 | 2008-07-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Re-Establishing a Metal-Binding Scaffold with Full Activity in the Metal-Independent Kdo8P Synthase from Neisseria Meningitidis
To be Published
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6MDY
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1D9E
 | | STRUCTURE OF E. COLI KDO8P SYNTHASE | | 分子名称: | 3-DEOXY-D-MANNO-OCTULOSONATE 8-PHOSPHATE SYNTHASE, SULFATE ION | | 著者 | Radaev, S, Dastidar, P, Patel, M, Woodard, R.W, Gatti, D.L. | | 登録日 | 1999-10-27 | | 公開日 | 2000-05-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure and mechanism of 3-deoxy-D-manno-octulosonate 8-phosphate synthase.
J.Biol.Chem., 275, 2000
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6AGL
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2EF9
 | | Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, ARABINOSE-5-PHOSPHATE, PHOSPHOENOLPYRUVATE | | 著者 | Kona, F, Xu, X, Martin, P, Kuzmic, P, Gatti, D.L. | | 登録日 | 2007-02-22 | | 公開日 | 2007-04-24 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases
Biochemistry, 46, 2007
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7YKC
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3TQK
 | | Structure of Phospho-2-dehydro-3-deoxyheptonate aldolase from Francisella tularensis SCHU S4 | | 分子名称: | ACETATE ION, CALCIUM ION, MANGANESE (II) ION, ... | | 著者 | Franklin, M.C, Cheung, J, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | | 登録日 | 2011-09-09 | | 公開日 | 2011-09-21 | | 最終更新日 | 2014-08-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction.
Plos One, 8, 2013
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3TMQ
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6AGM
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4C1K
 | | Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase | | 分子名称: | 2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATE ALDOLASE, CADMIUM ION, CARBONATE ION, ... | | 著者 | Nazmi, A.R, Schofield, L.R, Dobson, R.C.J, Jameson, G.B, Parker, E.J. | | 登録日 | 2013-08-13 | | 公開日 | 2013-11-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Destabilization of the Homotetrameric Assembly of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from the Hyperthermophile Pyrococcus Furiosus Enhances Enzymatic Activity
J.Mol.Biol., 426, 2014
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6U57
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6BNG
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6U8J
 | | Crystal structure of 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase/phospho-2-dehydro-3-deoxyheptonate aldolase (Aro3) from Candida auris | | 分子名称: | Phospho-2-dehydro-3-deoxyheptonate aldolase, UNKNOWN ATOM OR ION | | 著者 | Michalska, K, Evdokimova, E, Semper, C, Di Leo, R, Stogios, P.J, Savchenko, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2019-09-05 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.492 Å) | | 主引用文献 | Crystal structure of 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase/phospho-2-dehydro-3-deoxyheptonate aldolase (Aro3) from
Candida auris
To Be Published
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4C1L
 | | Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase I181D interface mutant | | 分子名称: | 2-dehydro-3-deoxyphosphoheptonate aldolase, CHLORIDE ION, MANGANESE (II) ION, ... | | 著者 | Nazmi, A.R, Schofield, L.R, Dobson, R.C.J, Jameson, G.B, Parker, E.J. | | 登録日 | 2013-08-13 | | 公開日 | 2013-11-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity.
J. Mol. Biol., 426, 2014
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7REU
 | | Crystal structure of Aro4p, 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase from Candida auris, L-Tyr complex | | 分子名称: | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, CHLORIDE ION, GLYCEROL, ... | | 著者 | Stogios, P.J, Evdokimova, E, Tan, K, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2021-07-13 | | 公開日 | 2021-07-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Crystal structure of Aro4p, 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase from Candida auris, L-Tyr complex
To Be Published
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4HSO
 | | Crystal structure of S213G variant DAH7PS from Neisseria meningitidis | | 分子名称: | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... | | 著者 | Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J. | | 登録日 | 2012-10-30 | | 公開日 | 2013-09-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.
Protein Sci., 22, 2013
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4HSN
 | | Crystal structure of DAH7PS from Neisseria meningitidis | | 分子名称: | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... | | 著者 | Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J. | | 登録日 | 2012-10-30 | | 公開日 | 2013-09-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.
Protein Sci., 22, 2013
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7RUD
 | | DAHP synthase complex with trifluoropyruvate oxime | | 分子名称: | (2Z)-3,3,3-trifluoro-2-(hydroxyimino)propanoic acid, Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive | | 著者 | Heimhalt, M, Mukherjee, P, Grainger, R, Szabla, R, Brown, C, Turner, R, Junop, M.S, Berti, P.J. | | 登録日 | 2021-08-16 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition.
Acs Infect Dis., 7, 2021
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7RUE
 | | DAHP synthase complexed with trifluoropyruvate semicarbazone | | 分子名称: | (2E)-2-(2-carbamoylhydrazinylidene)-3,3,3-trifluoropropanoic acid, MANGANESE (II) ION, Phospho-2-dehydro-3-deoxyheptonate aldolase, ... | | 著者 | Heimhalt, M, Mukherjee, P, Grainger, R, Szabla, R, Brown, C, Turner, R, Junop, M.S, Berti, P.J. | | 登録日 | 2021-08-16 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition.
Acs Infect Dis., 7, 2021
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4Z1B
 | | Structure of H204A mutant KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1C
 | | Structure of Cadmium bound KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, CADMIUM ION | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1A
 | | Structure of apo form KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4Z1D
 | | Structure of PEP and zinc bound KDO8PS from H.pylori | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ZINC ION | | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).
Eur.J.Med.Chem., 108, 2016
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4UMB
 | | Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water | | 分子名称: | (2R)-2-(phosphonooxy)propanoic acid, MANGANESE (II) ION, PHOSPHATE ION, ... | | 著者 | Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J. | | 登録日 | 2014-05-16 | | 公開日 | 2014-10-08 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
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