9DJ9
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in distinct apo form | 分子名称: | Dual specificity protein phosphatase 3 | 著者 | Keedy, D.A, Lemberikman, A.M, Isiorho, E.A, Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2024-09-06 | 公開日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (1.924 Å) | 主引用文献 | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
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8W8F
| human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | 分子名称: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ... | 著者 | Li, Y, Wang, Q, Xu, Y, Li, Z. | 登録日 | 2023-09-02 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
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8W8E
| human co-transcriptional RNA capping enzyme RNGTT | 分子名称: | DNA (36-MER), DNA (45-MER), DNA-directed RNA polymerase II subunit E, ... | 著者 | Li, Y, Wang, Q, Xu, Y, Li, Z. | 登録日 | 2023-09-02 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
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8TO0
| 48-nm repeating structure of doublets from mouse sperm flagella | 分子名称: | Cilia- and flagella- associated protein 210, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | 著者 | Chen, Z, Shiozak, M, Hass, K.M, Skinner, W, Zhao, S, Guo, C, Polacco, B.J, Yu, Z, Krogan, N.J, Kaake, R.M, Vale, R.D, Agard, D.A. | 登録日 | 2023-08-02 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell, 186, 2023
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8TK6
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in apo form | 分子名称: | Dual specificity protein phosphatase 3 | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
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8TK5
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with HEPES | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
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8TK4
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate | 分子名称: | Dual specificity protein phosphatase 3, PHOSPHATE ION | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate To Be Published
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8TK3
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites | 分子名称: | 6-(difluoromethyl)pyrimidin-4-ol, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3 | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites To Be Published
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8TK2
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid | 分子名称: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3, ... | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) binding 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid To Be Published
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8P4E
| Structural insights into human co-transcriptional capping - structure 5 | 分子名称: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (26-MER), DNA (35-MER), ... | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | 登録日 | 2023-05-20 | 公開日 | 2023-07-19 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural insights into human co-transcriptional capping. Mol.Cell, 83, 2023
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8P4D
| Structural insights into human co-transcriptional capping - structure 4 | 分子名称: | DNA (32-MER), DNA (41-MER), DNA-directed RNA polymerase II subunit E, ... | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | 登録日 | 2023-05-20 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into human co-transcriptional capping. Mol.Cell, 83, 2023
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8P4C
| Structural insights into human co-transcriptional capping - structure 3 | 分子名称: | DNA (32-MER), DNA (41-MER), DNA-directed RNA polymerase II subunit E, ... | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | 登録日 | 2023-05-20 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into human co-transcriptional capping. Mol.Cell, 83, 2023
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8P4B
| Structural insights into human co-transcriptional capping - structure 2 | 分子名称: | DNA (35-MER), DNA (5'-D(P*AP*GP*CP*GP*GP*CP*GP*GP*AP*GP*CP*CP*AP*GP*CP*AP*GP*GP*GP*AP*GP*CP*TP*G)-3'), DNA-directed RNA polymerase II subunit E, ... | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | 登録日 | 2023-05-20 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into human co-transcriptional capping. Mol.Cell, 83, 2023
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8P4A
| Structural insights into human co-transcriptional capping - structure 1 | 分子名称: | DNA (29-MER), DNA (38-MER), DNA-directed RNA polymerase II subunit E, ... | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | 登録日 | 2023-05-20 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into human co-transcriptional capping. Mol.Cell, 83, 2023
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8OTZ
| 48-nm repeat of the native axonemal doublet microtubule from bovine sperm | 分子名称: | ATP6V1F neighbor, CFAP97 domain containing 1, Chromosome 13 C20orf85 homolog, ... | 著者 | Leung, M.R, Zeng, J, Zhang, R, Zeev-Ben-Mordehai, T. | 登録日 | 2023-04-21 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural specializations of the sperm tail. Cell, 186, 2023
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8J5D
| Cryo-EM structure of starch degradation complex of BAM1-LSF1-MDH | 分子名称: | Beta-amylase 1, chloroplastic, Malate dehydrogenase, ... | 著者 | Guan, Z.Y, Liu, J, Yan, J.J. | 登録日 | 2023-04-21 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The LIKE SEX FOUR 1-malate dehydrogenase complex functions as a scaffold to recruit beta-amylase to promote starch degradation. Plant Cell, 36, 2023
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8IYJ
| Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm | 分子名称: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | 著者 | Zhou, L.N, Gui, M, Wu, J.P. | 登録日 | 2023-04-05 | 公開日 | 2023-07-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell, 186, 2023
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8I7R
| In situ structure of axonemal doublet microtubules in mouse sperm with 48-nm repeat | 分子名称: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | 著者 | Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. | 登録日 | 2023-02-02 | 公開日 | 2023-10-11 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov, 9, 2023
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8I7O
| In situ structure of axonemal doublet microtubules in mouse sperm with 16-nm repeat | 分子名称: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 276, ... | 著者 | Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. | 登録日 | 2023-02-01 | 公開日 | 2023-10-11 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov, 9, 2023
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8GZ4
| Crystal structure of MPXV phosphatase | 分子名称: | Dual specificity protein phosphatase H1, PHOSPHATE ION | 著者 | Yang, H.T, Wang, W, Huang, H.J, Ji, X.Y. | 登録日 | 2022-09-25 | 公開日 | 2023-05-17 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Crystal structure of monkeypox H1 phosphatase, an antiviral drug target. Protein Cell, 14, 2023
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7Y4E
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7Y4D
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7Y4C
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7Y4B
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7UN4
| Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor | 分子名称: | 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one, Dual specificity protein phosphatase 10 | 著者 | Gannam, Z.T.K, Jamali, H, Lolis, E, Anderson, K.S, Ellman, J.A, Bennett, A.M. | 登録日 | 2022-04-08 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors. Eur.J.Med.Chem., 243, 2022
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