6SIR
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3R5G
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8CO7
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7OVD
| Human soluble adenylyl cyclase in complex with the inhibitor TDI10229 | 分子名称: | 1,2-ETHANEDIOL, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... | 著者 | Steegborn, C, Quast, J. | 登録日 | 2021-06-14 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). Acs Med.Chem.Lett., 12, 2021
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2BW7
| A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen | 分子名称: | 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE, ADENYLATE CYCLASE, CALCIUM ION, ... | 著者 | Steegborn, C, Litvin, T.N, Hess, K.C, Capper, A.B, Taussig, R, Buck, J, Levin, L.R, Wu, H. | 登録日 | 2005-07-12 | 公開日 | 2005-07-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen J.Biol.Chem., 280, 2005
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3UVJ
| Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Guanylate cyclase soluble subunit alpha-3, ... | 著者 | Allerston, C.K, Berridge, G, Chalk, R, Cooper, C.D.O, Savitsky, P, Vollmar, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, von Delft, F, Gileadi, O, Structural Genomics Consortium (SGC) | 登録日 | 2011-11-30 | 公開日 | 2011-12-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal structures of the catalytic domain of human soluble guanylate cyclase. Plos One, 8, 2013
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5D0R
| Crystal structure of human soluble Adenylyl Cyclase with the inhibitor bithionol | 分子名称: | 1,2-ETHANEDIOL, 2,2'-sulfanediylbis(4,6-dichlorophenol), ACETATE ION, ... | 著者 | Kleinboelting, S, Steegborn, C. | 登録日 | 2015-08-03 | 公開日 | 2016-03-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J.Biol.Chem., 291, 2016
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3MR7
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1AB8
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2W01
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5IV4
| Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1 | 分子名称: | 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... | 著者 | Kleinboelting, S, Steegborn, C. | 登録日 | 2016-03-18 | 公開日 | 2016-08-17 | 最終更新日 | 2022-11-30 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
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8B75
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5IV3
| Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1 | 分子名称: | 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... | 著者 | Kleinboelting, S, Steegborn, C. | 登録日 | 2016-03-18 | 公開日 | 2016-08-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
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2WZ1
| STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLE GUANYLATE CYCLASE 1 BETA 3. | 分子名称: | 1,2-ETHANEDIOL, GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 | 著者 | Allerston, C.K, Cooper, C.D.O, Muniz, J, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2009-11-23 | 公開日 | 2009-12-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase. Plos One, 8, 2013
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4CLS
| Crystal structure of human soluble Adenylyl Cyclase with Pyrophosphate | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... | 著者 | Kleinboelting, S, Weyand, M, Steegborn, C. | 登録日 | 2014-01-15 | 公開日 | 2014-03-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLF
| Crystal structure of human soluble Adenylyl Cyclase (Apo form) | 分子名称: | ACETATE ION, ADENYLATE CYCLASE TYPE 10, GLYCEROL | 著者 | Kleinboelting, S, Moniot, S, Weyand, M, Steegborn, C. | 登録日 | 2014-01-14 | 公開日 | 2014-03-05 | 最終更新日 | 2019-04-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4UST
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4USV
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4USW
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5O5K
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5O5L
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5OYH
| crystal structure of the catalytic core of a rhodopsin-guanylyl cyclase with converted specificity in complex with ATPalphaS | 分子名称: | ADENOSINE-5'-SP-ALPHA-THIO-TRIPHOSPHATE, CALCIUM ION, GLYCEROL, ... | 著者 | Broser, M, Scheib, U, Hegemann, P. | 登録日 | 2017-09-09 | 公開日 | 2018-06-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.249 Å) | 主引用文献 | Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 angstrom structure of the adenylyl cyclase domain. Nat Commun, 9, 2018
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6AO9
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3ET6
| The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase | 分子名称: | PHOSPHATE ION, Soluble guanylyl cyclase beta | 著者 | Winger, J.A, Derbyshire, E.R, Lamers, M.H, Marletta, M.A, Kuriyan, J. | 登録日 | 2008-10-07 | 公開日 | 2008-10-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. Bmc Struct.Biol., 8, 2008
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6AOA
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