PDB: 672 件ウェブページステータス検索Chemie searchBIRD

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4UQK	Electron density map of GluA2em in complex with quisqualate and LY451646 分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2 著者 Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. 登録日 2014-06-24 公開日 2014-08-13 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (16.4 Å) 主引用文献 Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
7LVT	Structure of full-length GluK1 with L-Glu 分子名称: Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1 著者 Meyerson, J.R, Selvakumar, P. 登録日 2021-02-26 公開日 2021-11-03 最終更新日 2021-11-10 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural and compositional diversity in the kainate receptor family. Cell Rep, 37, 2021
6DM0	Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction 分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... 著者 Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. 登録日 2018-06-04 公開日 2018-08-22 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
5DT6	Crystal structure of the Drosophila GluR1A ligand binding domain complex with glutamate 分子名称: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 1 著者 Dharkar, P, Mayer, M.L. 登録日 2015-09-17 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.598 Å) 主引用文献 Novel Functional Properties of Drosophila CNS Glutamate Receptors. Neuron, 92, 2016
2GFE	Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Mayer, M.L. 登録日 2006-03-21 公開日 2006-08-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate. J.Neurosci., 26, 2006
6ZYU	Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549 分子名称: (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, ACETATE ION, ... 著者 Dorosz, J, Christensen, K.M, Kastrup, J.S. 登録日 2020-08-03 公開日 2021-08-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. Acs Chem Neurosci, 12, 2021
7VM2	GluK3 D759G mutant receptor complex with UBP310 and spermine 分子名称: Glutamate receptor ionotropic, kainate 3 著者 Assaiya, A, Kumar, J. 登録日 2021-10-06 公開日 2022-10-19 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 GluK3 D759G mutant receptor in complex with UBP310 and Spermine To Be Published
6CNA	GluN1-GluN2B NMDA receptors with exon 5 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Furukawa, H, Grant, T, Grigorieff, N. 登録日 2018-03-07 公開日 2018-10-03 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron, 98, 2018
4F2O	Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2012-05-08 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.912 Å) 主引用文献 The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
4F3G	Kainate bound to the ligand binding domain of GluA3i 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2012-05-09 公開日 2012-05-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.064 Å) 主引用文献 The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
6KSP	Rat GluD1 receptor(splayed conformation) in complex with 7-CKA and Calcium ions 分子名称: Glutamate receptor ionotropic, delta-1 著者 Burada, A.P, Kumar, J. 登録日 2019-08-24 公開日 2020-01-15 最終更新日 2020-01-29 実験手法 ELECTRON MICROSCOPY (8.1 Å) 主引用文献 Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture. Nat.Struct.Mol.Biol., 27, 2020
6KZM	GluK3 receptor complex with kainate 分子名称: Glutamate receptor ionotropic, kainate 3 著者 Kumar, J, Kumari, J, Burada, A.P. 登録日 2019-09-24 公開日 2020-03-04 実験手法 ELECTRON MICROSCOPY (9.6 Å) 主引用文献 Structural dynamics of the GluK3-kainate receptor neurotransmitter binding domains revealed by cryo-EM. Int.J.Biol.Macromol., 149, 2020
7QHB	Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... 著者 Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. 登録日 2021-12-11 公開日 2022-02-23 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
7QHH	Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... 著者 Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. 登録日 2021-12-12 公開日 2022-02-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
3H6T	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution 分子名称: ACETATE ION, CACODYLATE ION, CYCLOTHIAZIDE, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
6Q60	Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution 分子名称: (2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, CHLORIDE ION, GLYCEROL, ... 著者 Moellerud, S, Temperini, P, Kastrup, J.S. 登録日 2018-12-10 公開日 2019-04-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J.Med.Chem., 62, 2019
4O3B	Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution 分子名称: ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Krintel, C, de Rabassa, A.C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.906 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
4O3A	Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution 分子名称: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... 著者 Krintel, C, Frydenvang, F, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
4O3C	Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution 分子名称: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... 著者 Krintel, C, Frydenvang, K, Kaern, A.M, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
6QKC	GluA1/2 In complex with auxiliary subunit gamma-8 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 1, ... 著者 Herguedas, B, Garcia-Nafria, J, Greger, I.G. 登録日 2019-01-28 公開日 2019-03-27 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
3H6U	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution 分子名称: (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CITRATE ANION, GLUTAMIC ACID, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6V	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution 分子名称: (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
6QKZ	Full length GluA1/2-gamma8 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, ... 著者 Herguedas, B, Garcia-Nafria, J, Greger, I.G. 登録日 2019-01-30 公開日 2019-03-27 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
2I3V	Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. 登録日 2006-08-21 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
2I0B	Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2, ... 著者 Mayer, M.L. 登録日 2006-08-10 公開日 2006-11-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Conformational restriction blocks glutamate receptor desensitization. Nat.Struct.Mol.Biol., 13, 2006

 

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