9CHS
 
 | |
9CHR
 | |
9CHQ
 | |
9CHP
 | |
9BC7
 | | HCN1 M305L holo | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Kim, E.D, Nimigean, C.M. | | 登録日 | 2024-04-08 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
|
|
9BC6
 | | HCN1 M305L with propofol | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Kim, E.D, Nimigean, C.M. | | 登録日 | 2024-04-07 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
|
|
8ZYQ
 | | Cryo-EM Structure of pimozide-bound hERG Channel | | 分子名称: | 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 2024
|
|
8ZYP
 | | Cryo-EM Structure of E-4031-bound hERG Channel | | 分子名称: | Potassium voltage-gated channel subfamily H member 2, ~{N}-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidin-4-yl]carbonylphenyl]methanesulfonamide | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 2024
|
|
8ZYO
 | | Cryo-EM Structure of astemizole-bound hERG Channel | | 分子名称: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 2024
|
|
8ZYN
 | | Cryo-EM Structure of inhibitor-free hERG Channel | | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 2024
|
|
8YZ7
 | |
8XQA
 | |
8XQ9
 | |
8XQ8
 | |
8XQ7
 | |
8XQ4
 | |
8XPQ
 | |
8WUI
 | | SKOR D312N L271P double mutation | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR | | 著者 | Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G. | | 登録日 | 2023-10-20 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel.
Plant Commun., 5, 2024
|
|
8WTZ
 | | potassium outward rectifier channel SKOR | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR | | 著者 | Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel.
Plant Commun., 5, 2024
|
|
8VTB
 | | SthK R120A R124A in the presence of PIP2 and cAMP | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | 登録日 | 2024-01-26 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
|
|
8VTA
 | | SthK R120A in the presence of PIP2 and cAMP | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | 登録日 | 2024-01-26 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
|
|
8VT9
 | | WT SthK in the presence of PIP2 and cAMP | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | 登録日 | 2024-01-26 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
|
|
8UC8
 | | HCN1 nanodisc | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Kim, E.D, Nimigean, C.M. | | 登録日 | 2023-09-25 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
|
|
8UC7
 | | HCN1 complex with propofol | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Kim, E.D, Nimigean, C.M. | | 登録日 | 2023-09-25 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
|
|
8T50
 | | Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | | 登録日 | 2023-06-12 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
|
|
