PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... 著者 Clements, J.H. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
5JN0	CRK-II SH2 domain 分子名称: CHLORIDE ION, CRK-II SH2 domain 著者 Cho, J.-H. 登録日 2016-04-29 公開日 2017-08-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.677 Å) 主引用文献 CRK-II SH2 domain To Be Published
6R5G	C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1 分子名称: ITSM, Tyrosine-protein phosphatase non-receptor type 11 著者 Marasco, M. 登録日 2019-03-25 公開日 2020-02-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
5KAZ	Human SH2D1B structure 分子名称: SH2 domain-containing protein 1B, SULFATE ION 著者 Taha, M, Nezerwa, E, Nam, H.-J. 登録日 2016-06-02 公開日 2017-04-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The X-ray Crystallographic Structure of Human EAT2 (SH2D1B). Protein Pept. Lett., 23, 2016
1MIL	TRANSFORMING PROTEIN 分子名称: SHC ADAPTOR PROTEIN 著者 Mikol, V. 登録日 1995-09-20 公開日 1996-11-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data. J.Mol.Biol., 254, 1995
1MW4	Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139 分子名称: Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2 著者 Ivancic, M, Lyons, B.A. 登録日 2002-09-27 公開日 2003-09-09 最終更新日 2012-05-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2 J.BIOMOL.NMR, 27, 2003
2GE9	Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase 分子名称: Tyrosine-protein kinase BTK 著者 Cheng, J.-W, Huang, K.-C. 登録日 2006-03-18 公開日 2006-10-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase J.Biomol.Nmr, 36, 2006
4WWQ	Apo structure of the Grb7 SH2 domain 分子名称: Growth factor receptor-bound protein 7, MALONIC ACID 著者 Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. 登録日 2014-11-12 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
4X6S	Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide 分子名称: Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 著者 Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. 登録日 2014-12-09 公開日 2015-09-23 最終更新日 2015-10-28 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
7CIO	Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase 分子名称: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha 著者 Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2020-07-08 公開日 2020-12-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Mol.Immunol., 131, 2021
6E8H	Legionella Longbeachae LeSH (Llo2327) 分子名称: CHLORIDE ION, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8K	Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide 分子名称: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
3C7I	X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN. 分子名称: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide 著者 Benfield, A.P, Martin, S.F. 登録日 2008-02-07 公開日 2008-08-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 118, 2006
7T1L	Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide 分子名称: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1K	Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1U	Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide 分子名称: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION 著者 Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
4XZ0	ZAP-70-tSH2:compound-A complex 分子名称: 1-(3-{5-[(3-chlorobenzyl)sulfonyl]-1H-tetrazol-1-yl}phenyl)ethanone, SULFATE ION, Tyrosine-protein kinase ZAP-70 著者 Barros, T, Kuriyan, J, Visperas, P.R, Winger, J.A. 登録日 2015-02-03 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
1F1W	SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE 著者 Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. 登録日 2000-05-20 公開日 2000-07-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
1F2F	SRC SH2 THREF1TRP MUTANT 分子名称: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. 登録日 2000-05-24 公開日 2000-07-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
2YSX	Solution structure of the human SHIP SH2 domain 分子名称: Signaling inositol polyphosphate phosphatase SHIP II 著者 Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-04 公開日 2008-04-08 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the human SHIP SH2 domain To be Published
5X94	Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex 分子名称: Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11 著者 Senda, M, Senda, T. 登録日 2017-03-05 公開日 2017-09-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep, 20, 2017
3EAC	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form. 分子名称: Tyrosine-protein kinase CSK 著者 Liu, D, Seidel, R.D, Cowburn, D. 登録日 2008-08-25 公開日 2009-11-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
1FBZ	Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK, {4-[2-ACETYLAMINO-2-(3-CARBAMOYL-2-CYCLOHEXYLMETHOXY-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENYL}-PHOSPHONIC ACID 著者 Shakespeare, W, Yang, M, Bohacek, R, Cerasoli, F, Stebbis, K, Sundaramoorthi, R, Vu, C, Pradeepan, S, Metcalf, C, Haraldson, C, Merry, T, Dalgarno, D, Narula, S, Hatada, M, Lu, X, Van Schravendijk, M.R, Adams, S, Violette, S, Smith, J, Guan, W, Bartlett, C, Herson, J, Iuliucci, J, Weigele, M, Sawyer, T. 登録日 2000-07-17 公開日 2000-08-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc.Natl.Acad.Sci.Usa, 97, 2000
3EAZ	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant. 分子名称: Tyrosine-protein kinase CSK 著者 Liu, D, Seidel, R.D, Cowburn, D. 登録日 2008-08-26 公開日 2009-11-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
6ROY	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif 分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM) 著者 Krausze, J, Sikorska, J, Carlomagno, T. 登録日 2019-05-13 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020

 

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