PDB: 87 件ウェブページステータス検索Chemie searchBIRD

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9LMZ	hAGO2-MID in complex with a chemical modified uridine monophosphate 分子名称: (4S)-4-amino-5-hydroxypentanamide, Protein argonaute-2, [(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate 著者 Yao, Y.Q, Ma, J.B. 登録日 2025-01-20 公開日 2026-01-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 hAGO2-MID in complex with a chemical modified uridine monophosphate To Be Published
9LSO	hAGO2-MID in complex with a chemical modified uridine monophosphate 分子名称: (4S)-4-amino-5-hydroxypentanamide, Protein argonaute-2, [(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)thieno[3,4-d]pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate 著者 Yao, Y.Q, Ma, J.B. 登録日 2025-02-04 公開日 2026-02-11 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 hAGO2-MID in complex with a chemical modified uridine monophosphate To Be Published
9LSN	hAGO2-MID in complex with a chemical modified uridine monophosphate 分子名称: Protein argonaute-2, [(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)thieno[3,2-d]pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate 著者 Yao, Y.Q, Ma, J.B. 登録日 2025-02-04 公開日 2026-02-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 hAGO2-MID in complex with a chemical modified uridine monophosphate To Be Published
9BF2	MID domain of Ago2 bound to UMP 分子名称: Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE 著者 Harp, J.M, Egli, M. 登録日 2024-04-16 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
3QX9	Crystal structure of MID domain from hAGO2 in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Protein argonaute-2 著者 Frank, F, Fabian, M.R, Stepinski, J, Jemielity, J, Darzynkiewicz, E, Sonenberg, N, Nagar, B. 登録日 2011-03-01 公開日 2011-04-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. Embo Rep., 12, 2011
3QX8	Crystal structure of MID domain from hAGO2 in complex with m7GpppG 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Protein argonaute-2 著者 Frank, F, Fabian, M.R, Stepinski, J, Jemielity, J, Darzynkiewicz, E, Sonenberg, N, Nagar, B. 登録日 2011-03-01 公開日 2011-04-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. Embo Rep., 12, 2011
3LUC	Crystal structure of MID domain from hAGO2 分子名称: PHOSPHATE ION, Protein argonaute-2 著者 Frank, F, Sonenberg, N, Nagar, B. 登録日 2010-02-17 公開日 2010-05-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.691 Å) 主引用文献 Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature, 465, 2010
3LUJ	Crystal structure of MID domain from hAGO2 in complex with UMP 分子名称: Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE 著者 Frank, F, Sonenberg, N, Nagar, B. 登録日 2010-02-17 公開日 2010-05-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.796 Å) 主引用文献 Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature, 465, 2010
3LUD	Crystal structure of MID domain from hAGO2 in complex with AMP 分子名称: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2 著者 Frank, F, Sonenberg, N, Nagar, B. 登録日 2010-02-17 公開日 2010-05-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature, 465, 2010
3LUK	Crystal structure of MID domain from hAGO2 分子名称: GLYCEROL, PHOSPHATE ION, Protein argonaute-2 著者 Frank, F, Sonenberg, N, Nagar, B. 登録日 2010-02-17 公開日 2010-05-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature, 465, 2010
3LUH	Crystal structure of MID domain from hAGO2 in complex with GMP 分子名称: GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2 著者 Frank, F, Sonenberg, N, Nagar, B. 登録日 2010-02-17 公開日 2010-05-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature, 465, 2010
3LUG	Crystal structure of MID domain from hAGO2 in complex with CMP 分子名称: CYTIDINE-5'-MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2 著者 Frank, F, Sonenberg, N, Nagar, B. 登録日 2010-02-17 公開日 2010-05-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.849 Å) 主引用文献 Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature, 465, 2010
9BF0	MID domain of human Argo2 bound to UTP 分子名称: Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE 著者 Harp, J.M, Egli, M. 登録日 2024-04-16 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
9BEZ	MID domain of human Argo2 bound to RNA 分子名称: Protein argonaute-2, [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate 著者 Harp, J.M, Egli, M. 登録日 2024-04-16 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
8D71	Human Ago2 bound to miR122(21nt) 分子名称: MAGNESIUM ION, Protein argonaute-2, miR-122-21nt 著者 Xiao, Y, MacRae, I. 登録日 2022-06-07 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength. Embo Rep., 24, 2023
8D6J	Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence 分子名称: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 著者 Xiao, Y, MacRae, I. 登録日 2022-06-06 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength. Embo Rep., 24, 2023
7C6B	Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate 分子名称: 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2 著者 Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. 登録日 2020-05-21 公開日 2020-11-25 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
7D7U	Crystal structure of Ago2 MID domain in complex with 8-Br-adenosin-5'-monophosphate 分子名称: 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, Protein argonaute-2 著者 Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. 登録日 2020-10-06 公開日 2020-11-25 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
3MJ0	Crystal Structure of Drosophia Ago-PAZ domain in complex with 3'-end 2'-O-methylated RNA 分子名称: Protein argonaute-2, RNA (5'-R(*CP*GP*UP*UP*AP*CP*GP*CP*(OMU))-3') 著者 Huang, Y, Ding, L, Ma, J. 登録日 2010-04-12 公開日 2011-05-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.306 Å) 主引用文献 Crystal Structure of drosophila Ago2 PAZ domain in complex with 3'-end 2'-O-methylated RNA To be Published
4G0M	Crystal structure of Arabidopsis thaliana AGO2 MID domain 分子名称: Protein argonaute 2, SULFATE ION 著者 Frank, F, Hauver, J, Sonenberg, N, Nagar, B. 登録日 2012-07-09 公開日 2012-07-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.306 Å) 主引用文献 Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. Embo J., 31, 2012
2Q1O	Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2) 分子名称: RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') 著者 Li, F, Pallan, P.S. 登録日 2007-05-25 公開日 2007-10-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res., 35, 2007
2Q1R	Crystal Structure Analysis of the RNA Dodecamer CGCGAAUUAGCG, with a G-A mismatch. 分子名称: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3') 著者 Li, F, Pallan, P.S. 登録日 2007-05-25 公開日 2007-10-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res., 35, 2007
7KI3	Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA 分子名称: BARIUM ION, HCV genotype 1a miR-122 site-1, Protein argonaute-2, ... 著者 Gebert, L.F.R, MacRae, I.J. 登録日 2020-10-22 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome. Nat Commun, 12, 2021
4W5R	The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target) 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014
4W5Q	The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.101 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014

 

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