PDB: 226707 件ウェブページステータス検索Chemie searchBIRD

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8EBX	XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP) 分子名称: CALCIUM ION, Centrin-2, DNA, ... 著者 Kim, J, Yang, W. 登録日 2022-08-31 公開日 2023-04-19 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
6ZP3	Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 2-Methylindole-3-acetic acid 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(2-methyl-1~{H}-indol-3-yl)ethanoic acid, CALCIUM ION, ... 著者 Fata, F, Silvestri, I, Williams, D.L, Angelucci, F. 登録日 2020-07-08 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. Acs Infect Dis., 7, 2021
6PNZ	The structure of the Aspartate Transcarbamoylase trimer from Staphylococcus aureus complexed with PALA at 2.27 Resolution. 分子名称: Aspartate carbamoyltransferase, N-(PHOSPHONACETYL)-L-ASPARTIC ACID 著者 Edwards, B.F.P, Evans, D.R, Patel, C. 登録日 2019-07-03 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 The structure of the Aspartate Transcarbamoylase trimer from Staphylococcus aureus complexed with PALA at 2.27 Resolution. To Be Published
6TW7	Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918 分子名称: Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, TETRADECANOYL-COA, ... 著者 Brannigan, J.A. 登録日 2020-01-12 公開日 2021-07-21 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918 To Be Published
8E20	Cryo-EM structure of the full-length human NF1 dimer 分子名称: Isoform I of Neurofibromin 著者 Darling, J.E, Merk, A, Grisshammer, R, Ognjenovic, J. 登録日 2022-08-12 公開日 2023-04-26 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proc.Natl.Acad.Sci.USA, 120, 2023
6MAZ	Crystal structure of N-myristoyl transferase (NMT) G386E mutant from Plasmodium vivax in complex with inhibitor IMP-0366 分子名称: 1,2-ETHANEDIOL, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-08-29 公開日 2019-06-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure-Guided Identification of Resistance Breaking Antimalarial N‐Myristoyltransferase Inhibitors. Cell Chem Biol, 26, 2019
7MPY	Crystal structure of cytosolic HPPK-DHPS from A.thaliana 分子名称: Folate synthesis bifunctional protein 著者 Vadlamani, G, Bond, C.S. 登録日 2021-05-05 公開日 2021-12-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam. Plant Commun., 3, 2022
7MEX	Structure of yeast Ubr1 in complex with Ubc2 and N-degron 分子名称: E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... 著者 Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. 登録日 2021-04-08 公開日 2021-11-24 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
6MBI	Crystal Structure of SNX15 PX domain in domain swapped conformation form 2 分子名称: Sorting nexin-15 著者 Chandra, M, Collins, B.M. 登録日 2018-08-29 公開日 2018-09-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.834 Å) 主引用文献 Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nat Commun, 10, 2019
7AA2	Chaetomium thermophilum FAD-dependent oxidoreductase in complex with ABTS 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-ETHYL-2-[(2Z)-2-(3-ETHYL-6-SULFO-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)HYDRAZINO]-6-SULFO-3H-1,3-BENZOTHIAZOL-1-IUM, ... 著者 Svecova, L, Skalova, T, Kolenko, P, Koval, T, Oestergaard, L.H, Dohnalek, J. 登録日 2020-09-03 公開日 2021-05-26 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Acta Crystallogr D Struct Biol, 77, 2021
6PO6	MicroED Structure of a Natural Product VFAThiaGlu 分子名称: YFAThiaGlu 著者 Halaby, S, Gonen, T, Ting, C.P, Funk, M.A, van der Donk, W.A. 登録日 2019-07-03 公開日 2019-08-07 最終更新日 2023-11-15 実験手法 ELECTRON CRYSTALLOGRAPHY (1 Å) 主引用文献 Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products. Science, 365, 2019
8DJJ	Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates 分子名称: 3C-like proteinase nsp5 著者 Khan, M.B, Lu, J, Young, H.S, Lemieux, M.J. 登録日 2022-06-30 公開日 2023-04-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023
6TW8	Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917 分子名称: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... 著者 Brannigan, J.A. 登録日 2020-01-12 公開日 2021-07-21 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917 To Be Published
8DL9	Room temperature X-ray structure of SARS-CoV-2 main protease in complex with compound Z199538122 分子名称: 1-{4-[(naphthalen-1-yl)methyl]piperazin-1-yl}ethan-1-one, 3C-like proteinase 著者 Kovalevsky, A.Y, Coates, L, Kneller, D.W. 登録日 2022-07-07 公開日 2023-05-17 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 AI-Accelerated Design of Targeted Covalent Inhibitors for SARS-CoV-2. J.Chem.Inf.Model., 63, 2023
6ZY7	Cryo-EM structure of the entire Human topoisomerase II alpha in State 1 分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... 著者 Vanden Broeck, A, Lamour, V. 登録日 2020-07-30 公開日 2021-05-26 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.64 Å) 主引用文献 Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
6POA	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-(3-(Aminomethyl)-4-(pyridin-3-ylmethoxy)phenyl)-4-methylquinolin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-{3-(aminomethyl)-4-[(pyridin-3-yl)methoxy]phenyl}-4-methylquinolin-2-amine, Nitric oxide synthase, ... 著者 Li, H, Poulos, T.L. 登録日 2019-07-03 公開日 2020-04-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.809 Å) 主引用文献 First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63, 2020
7MU1	Thermotoga maritima encapsulin shell 分子名称: FLAVIN MONONUCLEOTIDE, Maritimacin 著者 LaFrance, B.J, Nogales, E, Savage, D.F. 登録日 2021-05-14 公開日 2021-11-24 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The encapsulin from Thermotoga maritima is a flavoprotein with a symmetry matched ferritin-like cargo protein. Sci Rep, 11, 2021
6TXH	Crystal structure of thermotoga maritima Ferritin in apo form 分子名称: EICOSANE, Ferritin, GLYCEROL, ... 著者 Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. 登録日 2020-01-14 公開日 2021-07-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
7A9T	Racemic compound of RNA duplexes. 分子名称: RNA (5'-R(*(0C)P*(0C)P*(0G)P*(0C)P*(0C)P*(0U)P*(0G)P*(0G))-3'), RNA (5'-R(*(0C)P*(0U)P*(0G)P*(0G)P*(0G)P*(0C)P*(0G)P*(0G))-3'), RNA (5'-R(*CP*CP*GP*CP*CP*UP*GP*G)-3'), ... 著者 Rypniewski, W. 登録日 2020-09-02 公開日 2021-05-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Broken symmetry between RNA enantiomers in a crystal lattice. Nucleic Acids Res., 49, 2021
8DQM	Crystal structure of isoaspartyl aminopeptidase from Roseivivax halodurans DSM 15395 分子名称: Isoaspartyl aminopeptidase, SODIUM ION 著者 Sharon, I, Schmeing, T.M. 登録日 2022-07-19 公開日 2023-04-26 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Bioinformatics of cyanophycin metabolism genes and characterization of promiscuous isoaspartyl dipeptidases that catalyze the final step of cyanophycin degradation. Sci Rep, 13, 2023
6PBE	ZINC17988990-bound TRPV5 in nanodiscs 分子名称: (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate, Transient receptor potential cation channel subfamily V member 5 著者 Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y. 登録日 2019-06-13 公開日 2019-11-06 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structure-based characterization of novel TRPV5 inhibitors. Elife, 8, 2019
6TV6	Octameric McsB from Bacillus subtilis. 分子名称: MAGNESIUM ION, Protein-arginine kinase 著者 Suskiewicz, M.J, Hajdusits, B, Meinhart, A, Clausen, T. 登録日 2020-01-09 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. Elife, 10, 2021
7MFC	Crystal structure of CSF1R in complex with vimseltinib 分子名称: Macrophage colony-stimulating factor 1 receptor, Vimseltinib 著者 Abendroth, J, Davies, D.R, Atkins, K. 登録日 2021-04-08 公開日 2021-11-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages. Mol.Cancer Ther., 20, 2021
6MBY	Carbonic Anhydrase II in complex with Ferulic Acid 分子名称: 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Lomelino, C.L, McKenna, R. 登録日 2018-08-30 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.496 Å) 主引用文献 Carbonic anhydrase II in complex with carboxylic acid-based inhibitors. Acta Crystallogr F Struct Biol Commun, 75, 2019
6ZY6	Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2 分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... 著者 Vanden Broeck, A, Lamour, V. 登録日 2020-07-30 公開日 2021-05-26 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021

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