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4HX4
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BU of 4hx4 by Molmil
Structure of MNTR mutant E11K complexed with Mn2+
分子名称: MANGANESE (II) ION, TRANSCRIPTIONAL REGULATOR MNTR
著者Glasfeld, A, McGuire, A.
登録日2012-11-09
公開日2012-11-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Roles of the A and C Sites in the Manganese-Specific Activation of MntR.
Biochemistry, 52, 2013
6I8W
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BU of 6i8w by Molmil
Crystal structure of a membrane phospholipase A, a novel bacterial virulence factor
分子名称: Alpha/beta fold hydrolase, CARBON DIOXIDE, ISOPROPYL ALCOHOL, ...
著者Granzin, J, Batra-Safferling, R.
登録日2018-11-21
公開日2019-11-27
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa.
Elife, 11, 2022
4HZI
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BU of 4hzi by Molmil
Crystal structure of the Leptospira interrogans ATPase subunit of an orphan ABC transporter
分子名称: ABC transporter ATP-binding protein, SULFATE ION
著者Saul, F.A, Haouz, A, Picardeau, M.
登録日2012-11-15
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and Functional Characterization of an Orphan ATP-Binding Cassette ATPase Involved in Manganese Utilization and Tolerance in Leptospira spp.
J.Bacteriol., 195, 2013
4FK5
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BU of 4fk5 by Molmil
Structure of the SAGA Ubp8(S144N)/Sgf11/Sus1/Sgf73 DUB module
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Protein SUS1, ...
著者Samara, N.L, Ringel, A.E, Wolberger, C.
登録日2012-06-12
公開日2012-07-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.032 Å)
主引用文献A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity.
Structure, 20, 2012
3VHW
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BU of 3vhw by Molmil
Crystal structure of the human vitamin D receptor ligand binding domain complexed with 4-MP
分子名称: Vitamin D3 receptor, methyl (1S,3E)-3-{(2R)-2-[(1R,3aS,4E,7aR)-4-{(2Z)-2-[(3R,4S,5R)-3,5-dihydroxy-4-(3-hydroxypropoxy)-2-methylidenecyclohexylidene]ethylidene}-7a-methyloctahydro-1H-inden-1-yl]propylidene}-1-ethyl-2-oxocyclopentanecarboxylate (non-preferred name)
著者Kakuda, S, Takimoto-Kamimura, M.
登録日2011-09-08
公開日2013-03-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone
J.Steroid Biochem.Mol.Biol., 136, 2013
1B3U
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BU of 1b3u by Molmil
CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
分子名称: PROTEIN (PROTEIN PHOSPHATASE PP2A)
著者Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D.
登録日1998-12-14
公開日1999-04-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
2ERR
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BU of 2err by Molmil
NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU
分子名称: Ataxin-2-binding protein 1, UGCAUGU
著者Allain, F.H, Auweter, S.D.
登録日2005-10-25
公開日2006-01-10
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Molecular basis of RNA recognition by the human alternative splicing factor Fox-1.
Embo J., 25, 2006
4I5L
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BU of 4i5l by Molmil
Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation
分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, MALONATE ION, ...
著者Wlodarchak, N, Satyshur, K.A, Guo, F, Xing, Y.
登録日2012-11-28
公開日2013-05-08
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
Cell Res., 23, 2013
1B85
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BU of 1b85 by Molmil
LIGNIN PEROXIDASE
分子名称: CALCIUM ION, Ligninase H8, PROTOPORPHYRIN IX CONTAINING FE
著者Blodig, W, Doyle, W.A, Smith, A.T, Piontek, K.
登録日1999-02-05
公開日1999-02-16
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structures of pristine and oxidatively processed lignin peroxidase expressed in Escherichia coli and of the W171F variant that eliminates the redox active tryptophan 171. Implications for the reaction mechanism.
J.Mol.Biol., 305, 2001
8EJ1
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BU of 8ej1 by Molmil
Dephosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)
分子名称: Cystic fibrosis transmembrane conductance regulator
著者Fiedorczuk, K, Chen, J.
登録日2022-09-16
公開日2022-10-19
最終更新日2025-05-14
実験手法ELECTRON MICROSCOPY (6.9 Å)
主引用文献Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
6UGO
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BU of 6ugo by Molmil
Human Carbonic Anhydrase IX-mimic complexed with SB4-205
分子名称: 5,7-dimethyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, CITRIC ACID, Carbonic anhydrase IX-mimic, ...
著者Murray, A.B, McKenna, R, Lomelino, C.L.
登録日2019-09-26
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.457 Å)
主引用文献"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
J.Med.Chem., 63, 2020
3N2K
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BU of 3n2k by Molmil
TUBULIN-NSC 613862: RB3 Stathmin-like domain complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Barbier, P, Dorleans, A, Devred, F, Sanz, L, Allegro, D, Alfonso, C, Knossow, M, Peyrot, V, Andreu, J.M.
登録日2010-05-18
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers.
J.Biol.Chem., 285, 2010
2F14
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BU of 2f14 by Molmil
Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor
分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, 5-{[({2-[4-(AMINOSULFONYL)PHENYL]ETHYL}AMINO)CARBONOTHIOYL]AMINO}-2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)BENZOIC ACID, Carbonic anhydrase 2, ...
著者Alterio, V, Pedone, C, De Simone, G.
登録日2005-11-14
公開日2006-10-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.
J.Am.Chem.Soc., 128, 2006
4IE5
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BU of 4ie5 by Molmil
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(3-hydroxypyridin-2-yl)carbonyl]glycine (MD6)
分子名称: Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, N-[(3-hydroxypyridin-2-yl)carbonyl]glycine, ...
著者Aik, W.S, McDonough, M.A, Schofield, C.J.
登録日2012-12-13
公開日2013-04-03
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
J.Med.Chem., 56, 2013
5C4J
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BU of 5c4j by Molmil
Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble
分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者Barnes, C.O, Calero, M, Malik, I, Spahr, H, Zhang, Q, Pullara, F, Kaplan, C.D, Calero, G.
登録日2015-06-18
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Mol.Cell, 59, 2015
4IEM
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BU of 4iem by Molmil
Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+
分子名称: DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*C)-3'), DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3'), ...
著者Tsutakawa, S.E, Mol, C.D, Arvai, A.S, Tainer, J.A.
登録日2012-12-13
公開日2013-01-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3936 Å)
主引用文献Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes.
J.Biol.Chem., 288, 2013
6UGP
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BU of 6ugp by Molmil
Human Carbonic Anhydrase 2 complexed with SB4-206
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-chloro-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, Carbonic anhydrase 2, ...
著者Murray, A.B, Lomelino, C.L, McKenna, R.
登録日2019-09-26
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.306 Å)
主引用文献"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
J.Med.Chem., 63, 2020
2C2H
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BU of 2c2h by Molmil
CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP
分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Debreczeni, J.E, Yang, X, Zao, Y, Elkins, J, Gileadi, C, Burgess, N, Colebrook, S, Gileadi, O, Fedorov, O, Bunkoczi, G, von Delft, F, Doyle, D, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A.
登録日2005-09-29
公開日2005-10-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of the Human Rac3 in Complex with Gdp
To be Published
6HR3
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BU of 6hr3 by Molmil
Human Carbonic Anhydrase II in complex with 4-Propylbenzenesulfonamide
分子名称: 4-propylbenzenesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
著者Gloeckner, S, Heine, A, Klebe, G.
登録日2018-09-26
公開日2019-10-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.02 Å)
主引用文献Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
8EIG
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BU of 8eig by Molmil
The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg
分子名称: (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
著者Fiedorczuk, K, Chen, J.
登録日2022-09-15
公開日2022-10-19
最終更新日2025-05-14
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
2F3R
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BU of 2f3r by Molmil
Crystal Structure Of E.coli Guanylate Kinase In Complex With Ap5G
分子名称: Guanylate kinase, P1-(5'-ADENOSYL)-P5-(5'-GUANOSYL) PENTAPHOSPHATE
著者Hible, G, Cherfils, J.
登録日2005-11-22
公開日2006-05-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G.
Biochimie, 88, 2006
1APM
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BU of 1apm by Molmil
2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT
分子名称: N-OCTANE, PEPTIDE INHIBITOR PKI(5-24), cAMP-DEPENDENT PROTEIN KINASE
著者Knighton, D.R, Bell, S.M, Zheng, J, Teneyck, L.F, Xuong, N.-H, Taylor, S.S, Sowadski, J.M.
登録日1993-01-18
公開日1993-04-15
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent.
Acta Crystallogr.,Sect.D, 49, 1993
8E9I
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BU of 8e9i by Molmil
Mycobacterial respiratory complex I, semi-inserted quinone
分子名称: (2R)-3-{[(R)-hydroxy({(1S,2R,3R,4R,5S,6S)-3,4,5-trihydroxy-2-(alpha-D-mannopyranosyloxy)-6-[(6-O-undecanoyl-beta-D-mannopyranosyl)oxy]cyclohexyl}oxy)phosphoryl]oxy}-2-(octanoyloxy)propyl undecanoate, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
著者Liang, Y, Rubinstein, J.L.
登録日2022-08-26
公開日2022-10-12
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structure of mycobacterial respiratory complex I.
Proc.Natl.Acad.Sci.USA, 120, 2023
8ECY
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BU of 8ecy by Molmil
cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex
分子名称: Bestrophin, CALCIUM ION, CHLORIDE ION, ...
著者Owji, A.P, Kittredge, A.K, Yang, T.
登録日2022-09-02
公開日2022-11-02
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Nature, 611, 2022
8E9G
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BU of 8e9g by Molmil
Mycobacterial respiratory complex I with both quinone positions modelled
分子名称: (2R)-3-{[(R)-hydroxy({(1S,2R,3R,4R,5S,6S)-3,4,5-trihydroxy-2-(alpha-D-mannopyranosyloxy)-6-[(6-O-undecanoyl-beta-D-mannopyranosyl)oxy]cyclohexyl}oxy)phosphoryl]oxy}-2-(octanoyloxy)propyl undecanoate, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
著者Liang, Y, Rubinstein, J.L.
登録日2022-08-26
公開日2022-10-12
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structure of mycobacterial respiratory complex I.
Proc.Natl.Acad.Sci.USA, 120, 2023

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