3VHW
Crystal structure of the human vitamin D receptor ligand binding domain complexed with 4-MP
Summary for 3VHW
Entry DOI | 10.2210/pdb3vhw/pdb |
Descriptor | Vitamin D3 receptor, methyl (1S,3E)-3-{(2R)-2-[(1R,3aS,4E,7aR)-4-{(2Z)-2-[(3R,4S,5R)-3,5-dihydroxy-4-(3-hydroxypropoxy)-2-methylidenecyclohexylidene]ethylidene}-7a-methyloctahydro-1H-inden-1-yl]propylidene}-1-ethyl-2-oxocyclopentanecarboxylate (non-preferred name) (3 entities in total) |
Functional Keywords | hormone receptor, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P11473 |
Total number of polymer chains | 1 |
Total formula weight | 30376.10 |
Authors | Kakuda, S.,Takimoto-Kamimura, M. (deposition date: 2011-09-08, release date: 2013-03-06, Last modification date: 2023-11-08) |
Primary citation | Saito, H.,Takagi, K.,Horie, K.,Kakuda, S.,Takimoto-Kamimura, M.,Ochiai, E.,Chida, T.,Harada, Y.,Takenouchi, K.,Kittaka, A. Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone J.Steroid Biochem.Mol.Biol., 136:3-8, 2013 Cited by PubMed: 23416104DOI: 10.1016/j.jsbmb.2013.02.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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