4ZZ3
 
 | | Human GAR transformylase in complex with GAR and pemetrexed | | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | | 著者 | Deis, S.M, Dann III, C.E. | | 登録日 | 2015-05-22 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | | 主引用文献 | 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors.
J.Med.Chem., 58, 2015
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4J8L
 | | CRYSTAL STRUCTURE OF THE PYRIDOXAL-5'-PHOSPHATE DEPENDENT protein YhfS from Escherichia coli | | 分子名称: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, NICKEL (II) ION, ... | | 著者 | Fedorov, A.A, Fedorov, E.V, Xiang, D.F, Raushel, F.M, Almo, S.C. | | 登録日 | 2013-02-14 | | 公開日 | 2014-03-05 | | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | | 主引用文献 | Crystal structure of the pyridoxal-5'-phosphate dependent protein yhfs from escherichia coli
To be Published
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4KH1
 | | The R state structure of E. coli ATCase with CTP,UTP, and Magnesium bound | | 分子名称: | Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... | | 著者 | Cockrell, G.M, Zheng, Y, Guo, W, Peterson, A.W, Kantrowitz, E.R. | | 登録日 | 2013-04-29 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 52, 2013
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2E68
 | | Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate | | 分子名称: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, ... | | 著者 | Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. | | 登録日 | 2006-12-26 | | 公開日 | 2008-01-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate
To be Published
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2NSL
 | | E. coli PurE H45N mutant complexed with CAIR | | 分子名称: | 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, Phosphoribosylaminoimidazole carboxylase catalytic subunit | | 著者 | Ealick, S.E, Morar, M. | | 登録日 | 2006-11-04 | | 公開日 | 2007-04-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
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7JLO
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7JLP
 | | cryo-EM structure of human ATG9A in nanodiscs | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Autophagy-related protein 9A | | 著者 | Maeda, S, Otomo, T. | | 登録日 | 2020-07-30 | | 公開日 | 2020-10-28 | | 最終更新日 | 2020-12-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Nat.Struct.Mol.Biol., 27, 2020
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2NSH
 | | E. coli PurE H45Q mutant complexed with nitro-AIR | | 分子名称: | ((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE, Phosphoribosylaminoimidazole carboxylase catalytic subunit | | 著者 | Ealick, S.E, Morar, M. | | 登録日 | 2006-11-04 | | 公開日 | 2007-04-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
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4KGZ
 | | The R state structure of E. coli ATCase with UTP and Magnesium bound | | 分子名称: | Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, MAGNESIUM ION, ... | | 著者 | Cockrell, G.M, Zheng, Y, Guo, W, Peterson, A.W, Kantrowitz, E.R. | | 登録日 | 2013-04-29 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 52, 2013
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2UKD
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4KGV
 | | The R state structure of E. coli ATCase with ATP bound | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, ... | | 著者 | Cockrell, G.M, Zheng, Y, Guo, W, Peterson, A.W, Kantrowitz, E.R. | | 登録日 | 2013-04-29 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 52, 2013
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2CNU
 | | Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with aspartic acid | | 分子名称: | ASPARTIC ACID, PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE, SULFATE ION | | 著者 | Urusova, D.V, Antonyuk, S.V, Grebenko, A.I, Levdikov, V.M, Barynin, V.V, Popov, A.N, Lamzin, V.S, Melik-Adamyan, W.R. | | 登録日 | 2006-05-24 | | 公開日 | 2006-06-07 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Saicar Synthase: Substrate Recognition, Conformational Flexibility and Catalysis.
To be Published
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2QZ9
 | | crystal structure of aspartate semialdehyde dehydrogenase II from vibrio cholerae | | 分子名称: | Aspartate-semialdehyde dehydrogenase | | 著者 | Viola, R.E, Liu, X, Ohren, J.F, Faehnle, C.R. | | 登録日 | 2007-08-16 | | 公開日 | 2008-04-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.
Acta Crystallogr.,Sect.D, 64, 2008
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2D0U
 | | Crystal structure of cyanide bound form of human indoleamine 2,3-dioxygenase | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CYANIDE ION, Indoleamine 2,3-dioxygenase, ... | | 著者 | Sugimoto, H, Oda, S, Otsuki, T, Hino, T, Yoshida, T, Shiro, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-08-08 | | 公開日 | 2006-01-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2CG9
 | | Crystal structure of an Hsp90-Sba1 closed chaperone complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, CO-CHAPERONE PROTEIN SBA1 | | 著者 | Ali, M.M.U, Roe, S.M, Prodromou, C, Pearl, L.H. | | 登録日 | 2006-03-01 | | 公開日 | 2006-04-12 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex
Nature, 440, 2006
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2FAP
 | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA | | 分子名称: | C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FRAP | | 著者 | Liang, J, Choi, J, Clardy, J. | | 登録日 | 1998-09-22 | | 公開日 | 1999-05-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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4LGY
 | | Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis | | 分子名称: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | 著者 | Tanwar, A.S, Goyal, V.D, Choudhary, D, Panjikar, S, Anand, R. | | 登録日 | 2013-06-30 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis
Plos One, 8, 2013
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4L6O
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4L2N
 | | Understanding Extradiol Dioxygenase Mechanism in NAD+ Biosynthesis by Viewing Catalytic Intermediates - ligand-free structure | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, CHLORIDE ION, ... | | 著者 | Liu, F, Liu, A. | | 登録日 | 2013-06-04 | | 公開日 | 2015-05-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
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2FW6
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4ZJY
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4ZMB
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2PPP
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4L64
 | | Crystal structure of the Candida albicans Methionine Synthase in complex with 5-Methyl-Tetrahydrofolate | | 分子名称: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, ZINC ION | | 著者 | Ubhi, D, Robertus, J.D. | | 登録日 | 2013-06-11 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural analysis of a fungal methionine synthase with substrates and inhibitors.
J.Mol.Biol., 426, 2014
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4ZC8
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