1HK9
 
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3V2A
 | | VEGFR-2/VEGF-A COMPLEX STRUCTURE | | 分子名称: | Vascular endothelial growth factor A, Vascular endothelial growth factor receptor 2 | | 著者 | Brozzo, M.S, Leppanen, V.-M, Winkler, F.K, Ballmer-Hofer, K. | | 登録日 | 2011-12-12 | | 公開日 | 2012-01-18 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.204 Å) | | 主引用文献 | Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.
Blood, 119, 2012
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9DQT
 | | Binary substrate complex of DNA polymerase iota with DNA (template A) | | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota | | 著者 | Frevert, Z, Reusch, D, Freudenthal, B, Washington, M.T. | | 登録日 | 2024-09-24 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis
Nat Commun, 16, 2025
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3V35
 | | Aldose reductase complexed with a nitro compound | | 分子名称: | 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate, Aldose reductase, DIMETHYLFORMAMIDE, ... | | 著者 | Zheng, X, Zhang, L, Chen, Y, Luo, H, Hu, X. | | 登録日 | 2011-12-13 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7, 2012
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4IFH
 | | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619 | | 分子名称: | Insulin-degrading enzyme, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide, ZINC ION | | 著者 | Liang, W.G, Guo, Q, Deprez, R, Deprez, B, Tang, W. | | 登録日 | 2012-12-14 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.286 Å) | | 主引用文献 | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
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9DQU
 | | Product complex of DNA polymerase iota with Pyrophosphate | | 分子名称: | DNA (5'-D(P*AP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*CP*T)-3'), DNA polymerase iota, MAGNESIUM ION, ... | | 著者 | Frevert, Z, Reusch, D, Freudenthal, B, Washington, M.T. | | 登録日 | 2024-09-24 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis
Nat Commun, 16, 2025
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3I4N
 | | 8-oxoguanine containing RNA polymerase II elongation complex E | | 分子名称: | DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Damsma, G.E, Cramer, P. | | 登録日 | 2009-07-02 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Molecular basis of transcriptional mutagenesis at 8-oxoguanine
J.Biol.Chem., 284, 2009
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6RIT
 | | Human Carbonic Anhydrase II in complex with 2-Fluorobenzenesulfonamide | | 分子名称: | (4-CARBOXYPHENYL)(CHLORO)MERCURY, 2-fluorobenzenesulfonamide, Carbonic anhydrase 2, ... | | 著者 | Gloeckner, S, Heine, A, Klebe, G. | | 登録日 | 2019-04-25 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.007 Å) | | 主引用文献 | The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II.
Biomolecules, 10, 2020
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9DR7
 | | Product complex of DNA polymerase iota with 2 monophosphates | | 分子名称: | DNA (5'-D(P*AP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*CP*T)-3'), DNA polymerase iota, MAGNESIUM ION, ... | | 著者 | Frevert, Z, Reusch, D, Freudenthal, B, Washington, M.T. | | 登録日 | 2024-09-25 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis
Nat Commun, 16, 2025
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9DRB
 | | Binary complex of DNA polymerase iota with product DNA | | 分子名称: | DNA (5'-D(P*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*CP*T)-3'), DNA polymerase iota | | 著者 | Frevert, Z, Reusch, D, Freudenthal, B, Washington, M.T. | | 登録日 | 2024-09-25 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis
Nat Commun, 16, 2025
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8DTB
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9DRC
 | | Ternary substrate complex of DNA polymerase iota R71A mutant with DNA (template A) and dTTP | | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ... | | 著者 | Frevert, Z, Reusch, D, Freudenthal, B, Washington, M.T. | | 登録日 | 2024-09-25 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis
Nat Commun, 16, 2025
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6JCK
 | | Complex structure of Axin-DIX and Dvl2-DIX | | 分子名称: | Axin-1, Segment polarity protein dishevelled homolog DVL-2 | | 著者 | Yamanishi, K, Shibata, N. | | 登録日 | 2019-01-29 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to beta-catenin.
Sci.Signal., 12, 2019
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3L9I
 | | Myosin VI nucleotide-free (mdinsert2) L310G mutant crystal structure | | 分子名称: | ACETATE ION, CALCIUM ION, Calmodulin, ... | | 著者 | Pylypenko, O, Song, L, Sweeney, L.H, Houdusse, A. | | 登録日 | 2010-01-05 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Role of insert i of myosin VI in modulating nucleotide affinity
To be Published
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8DVE
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6UX1
 | | Carbonic Anhydrase II Complexed with Salicylic Acid | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-HYDROXYBENZOIC ACID, Carbonic anhydrase 2, ... | | 著者 | Andring, J.T, Combs, J.E, McKenna, R. | | 登録日 | 2019-11-06 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II.
Biomolecules, 10, 2020
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1R7E
 | | NMR structure of the membrane anchor domain (1-31) of the nonstructural protein 5A (NS5A) of hepatitis C virus (Minimized average structure. Sample in 100mM SDS). | | 分子名称: | Genome polyprotein | | 著者 | Penin, F, Brass, V, Appel, N, Ramboarina, S, Montserret, R, Ficheux, D, Blum, H.E, Bartenschlager, R, Moradpour, D. | | 登録日 | 2003-10-21 | | 公開日 | 2004-08-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.
J.Biol.Chem., 279, 2004
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1R7H
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3J0K
 | | Orientation of RNA polymerase II within the human VP16-Mediator-pol II-TFIIF assembly | | 分子名称: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | | 著者 | Bernecky, C, Grob, P, Ebmeier, C.C, Nogales, E, Taatjes, D.J. | | 登録日 | 2011-10-04 | | 公開日 | 2011-10-19 | | 最終更新日 | 2024-11-27 | | 実験手法 | ELECTRON MICROSCOPY (36 Å) | | 主引用文献 | Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly.
Plos Biol., 9, 2011
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6UQK
 | | Cryo-EM structure of type 3 IP3 receptor revealing presence of a self-binding peptide | | 分子名称: | ZINC ION, inositol 1,4,5-triphosphate receptor, type 3 | | 著者 | Azumaya, C.M, Linton, E.A, Risener, C.J, Nakagawa, T, Karakas, E. | | 登録日 | 2019-10-20 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | | 主引用文献 | Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
J.Biol.Chem., 295, 2020
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6ROF
 | | Human Carbonic anhydrase II mutant T199V bound by 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide | | 分子名称: | 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | | 著者 | Smirnov, A, Paketuryte, V, Manakova, E, Grazulis, S. | | 登録日 | 2019-05-12 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Human Carbonic anhydrase II mutant T199V bound by 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
To Be Published
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6JH6
 | | Structure of RyR2 (F/A/Ca2+ dataset) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, RyR2, ... | | 著者 | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | | 登録日 | 2019-02-17 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
Proc.Natl.Acad.Sci.USA, 116, 2019
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1ZQG
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1ZQS
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6JRR
 | | Structure of RyR2 (*F/A/C/L-Ca2+ dataset) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | | 登録日 | 2019-04-05 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin.
Nature, 572, 2019
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