3V2A

VEGFR-2/VEGF-A COMPLEX STRUCTURE

Summary for 3V2A

Entry DOI	10.2210/pdb3v2a/pdb
Related	2GNN 2X1W 2X1X 3V6B
Descriptor	Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor A (2 entities in total)
Functional Keywords	ig-homology domain, vegfr-2, growth factor receptor, vegf ligand, hormone-signaling protein complex, angiogenesis, membrane, vegf-a, hormone/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 Secreted : P15692
Total number of polymer chains	2
Total formula weight	102109.06
Authors	Brozzo, M.S.,Leppanen, V.-M.,Winkler, F.K.,Ballmer-Hofer, K. (deposition date: 2011-12-12, release date: 2012-01-18, Last modification date: 2024-04-03)
Primary citation	Brozzo, M.S.,Bjelic, S.,Kisko, K.,Schleier, T.,Leppanen, V.M.,Alitalo, K.,Winkler, F.K.,Ballmer-Hofer, K. Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood, 119:1781-1788, 2012 Cited by PubMed: 22207738 DOI: 10.1182/blood-2011-11-390922 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.204 Å)

Structure validation