PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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9FI4	Bacteroides ovatus polysaccharide lyase family 38 (BoPL38) mutant Q173N at pH 8 分子名称: Alginate lyase family protein 著者 Tandrup, T, Wilkens, C. 登録日 2024-05-28 公開日 2025-07-09 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 The Swiss Army Knife of Alginate Metabolism: Mechanistic Analysis of a Mixed-Function Polysaccharide Lyase/Epimerase of the Human Gut Microbiota. J.Am.Chem.Soc., 2025
6U26	PCSK9 in complex with compound 16 分子名称: 4'-{[(1R)-6-{2-[2-({N~5~-[N,N'-bis(tert-butoxycarbonyl)carbamimidoyl]-N~2~-(tert-butoxycarbonyl)-L-ornithyl}amino)ethoxy]ethoxy}-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-2'-fluoro[1,1'-biphenyl]-4-carboxylic acid, Proprotein convertase subtilisin/kexin type 9 著者 Orth, P. 登録日 2019-08-19 公開日 2019-11-06 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
8GA8	Structure of the yeast (HDAC) Rpd3L complex 分子名称: Histone deacetylase RPD3, Transcriptional regulatory protein DEP1, Transcriptional regulatory protein PHO23, ... 著者 Patel, A.B, Radhakrishnan, I, He, Y. 登録日 2023-02-22 公開日 2023-07-12 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Nat Commun, 14, 2023
9FUA	Wobbly CODH/ACS in the acetlyated state 分子名称: CO-methylating acetyl-CoA synthase, Carbon monoxide dehydrogenase, Fe(3)-Ni(1)-S(4) cluster, ... 著者 Ruickoldt, J, Wendler, P, Dobbek, H. 登録日 2024-06-26 公開日 2025-07-09 実験手法 ELECTRON MICROSCOPY (2.04 Å) 主引用文献 The CODH/ACS complex caught in action To Be Published
3P3H	Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... 著者 Salmon, A.J. 登録日 2010-10-04 公開日 2011-09-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors. Chem.Commun.(Camb.), 48, 2012
6U2P	PCSK9 in complex with compound 5 分子名称: 1,2-ETHANEDIOL, 2-fluoro-4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid, Proprotein convertase subtilisin/kexin type 9 著者 Lu, J, Soisson, S. 登録日 2019-08-20 公開日 2019-11-06 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
3TAU	Crystal Structure of a Putative Guanylate Monophosphaste Kinase from Listeria monocytogenes EGD-e 分子名称: Guanylate kinase, SODIUM ION, SULFATE ION 著者 Brunzelle, J.S, Wawrzak, Z, Onopriyenko, O, Kwok, J, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2011-08-04 公開日 2011-08-24 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal Structure of a Putative Guanylate Monophosphaste Kinase from Listeria monocytogenes EGD-e To be Published
3P55	Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... 著者 Salmon, A.J. 登録日 2010-10-07 公開日 2011-10-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors. Chem.Commun.(Camb.), 48, 2012
2DEW	Crystal structure of human peptidylarginine deiminase 4 in complex with histone H3 N-terminal tail including Arg8 分子名称: 10-mer peptide from histone H3, CALCIUM ION, Protein-arginine deiminase type IV, ... 著者 Arita, K, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M. 登録日 2006-02-18 公開日 2006-04-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4 Proc.Natl.Acad.Sci.Usa, 103, 2006
3P58	Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid 分子名称: Carbonic anhydrase 2, ZINC ION, benzyl(methyl)carbamodithioic acid 著者 Aggarwal, M, McKenna, R. 登録日 2010-10-08 公開日 2011-10-19 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. Chem.Commun.(Camb.), 48, 2012
6U4Q	Carbonic anhydrase 2 in complex with SB4197 分子名称: 4-methyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, Carbonic anhydrase 2, ZINC ION 著者 Murray, A.B, Lomelino, C.L, McKenna, R. 登録日 2019-08-26 公開日 2020-01-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.306 Å) 主引用文献 "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J.Med.Chem., 63, 2020
3HVU	1.95 Angstrom Crystal Structure of Complex of Hypoxanthine-Guanine Phosphoribosyltransferase from Bacillus anthracis with 2-(N-morpholino)ethanesulfonic acid (MES) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hypoxanthine phosphoribosyltransferase, SODIUM ION 著者 Minasov, G, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2009-06-16 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 1.95 Angstrom Crystal Structure of Complex of Hypoxanthine-Guanine Phosphoribosyltransferase from Bacillus anthracis with 2-(N-morpholino)ethanesulfonic acid (MES) TO BE PUBLISHED
3T95	Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 分子名称: (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran, Autoinducer 2-binding protein lsrB 著者 Kavanaugh, J.S, Gakhar, L, Horswill, A.R. 登録日 2011-08-02 公開日 2011-12-07 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The structure of LsrB from Yersinia pestis complexed with autoinducer-2. Acta Crystallogr.,Sect.F, 67, 2011
1HGX	HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE (HGXPRTASE) 分子名称: GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE, SULFATE ION 著者 Somoza, J.R, Wang, C.C, Fletterick, R.J. 登録日 1996-03-12 公開日 1996-08-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus. Biochemistry, 35, 1996
6RG5	Human Carbonic Anhydrase II in complex with 4-(2-hydroxyethyl)benzenesulfonamide 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 4-(2-hydroxyethyl)benzenesulfonamide, Carbonic anhydrase 2, ... 著者 Gloeckner, S, Heine, A, Klebe, G. 登録日 2019-04-16 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.089 Å) 主引用文献 Human Carbonic Anhydrase II in complex with 4-(2-hydroxyethyl)benzenesulfonamide To Be Published
4BBR	Structure of RNA polymerase II-TFIIB complex 分子名称: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... 著者 Sainsbury, S, Niesser, J, Cramer, P. 登録日 2012-09-27 公開日 2012-11-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure and Function of the Initially Transcribing RNA Polymerase II-TFIIB Complex Nature, 493, 2013
6RIG	Human Carbonic Anhydrase II in complex with 4-Hydroxybenzenesulfonamide 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 4-oxidanylbenzenesulfonamide, Carbonic anhydrase 2, ... 著者 Gloeckner, S, Heine, A, Klebe, G. 登録日 2019-04-24 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (0.999 Å) 主引用文献 Human Carbonic Anhydrase II in complex with 4-Hydroxybenzenesulfonamide To Be Published
8UUI	X-ray structure of Interleukin-23 in complex with peptide 23-446 分子名称: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Joseph, J.S, Sridhar, V.S, Liu, M, Hu, Y, Gatchalian, J. 登録日 2023-11-01 公開日 2025-07-09 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Identification of an Induced Orthosteric Pocket in IL-23: A New Avenue for Non-biological Therapeutic Targeting. Acs Chem.Biol., 2025
9CDJ	MORC2 ATPase with DNA 分子名称: ATPase MORC2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Tan, W, Shakeel, S. 登録日 2024-06-25 公開日 2025-07-09 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 MORC2 is a phosphorylation-dependent DNA compaction machine. Nat Commun, 16, 2025
4INQ	Crystal structure of Osh3 ORD in complex with PI(4)P from Saccharomyces cerevisiae 分子名称: (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Oxysterol-binding protein homolog 3 著者 Tong, J, Im, Y.J. 登録日 2013-01-05 公開日 2013-07-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins Structure, 21, 2013
2AJQ	Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing 分子名称: DNA Primer, DNA Template, T7 DNA polymerase, ... 著者 Brieba, L, Ellenberger, T. 登録日 2005-08-02 公開日 2006-09-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing To be Published
9OIM	The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 9 分子名称: 1-[5-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]-2,3-dihydroindol-1-yl]ethanone, Elongin-B, Elongin-C, ... 著者 Amporndanai, K, Katinas, J.M, Chopra, A, Fesik, S.W. 登録日 2025-05-06 公開日 2025-07-09 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex Acs Med.Chem.Lett., 2025
9NJH	Translocated product complex of DNA polymerase iota with DNA (template A) 分子名称: CALCIUM ION, DNA (5'-D(P*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota 著者 Frevert, Z, Freudenthal, B, Washington, M.T. 登録日 2025-02-27 公開日 2025-07-09 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis Nat Commun, 16, 2025
2EC0	RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP 分子名称: 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', 5'-R(P*AP*UP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2007-02-09 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
9U9C	Crystal structure of NDM-1 in complex with hydrolyzed amoxicillin 分子名称: (2~{R},4~{S})-2-[(1~{R})-1-[[(2~{R})-2-azanyl-2-(4-hydroxyphenyl)ethanoyl]amino]-2-oxidanyl-2-oxidanylidene-ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Metallo-beta-lactamase type 2, ZINC ION 著者 Shi, X, Zhang, Q, Liu, W. 登録日 2025-03-27 公開日 2025-07-09 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Crystal structure reveals the hydrophilic R1 group impairs NDM-1-ligand binding via water penetration at L3 J Struct Biol X, 2025

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