PDB: 184427 件ウェブページステータス検索Chemie searchBIRD

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6NTZ	Crystal structure of E. coli PBP5-meropenem 分子名称: (2S,3R,4S)-4-{[(3S,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, D-alanyl-D-alanine carboxypeptidase 著者 Caveney, N.A, Strynadka, N.C.J, Caballero, G, Worrall, L.J. 登録日 2019-01-30 公開日 2019-03-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli. Nat Commun, 10, 2019
5CCO	Staphylococcus bacteriophage 80alpha dUTPase with dUMP. 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DUTPase, MAGNESIUM ION 著者 Maiques, E, Quiles-Puchalt, N, Donderis, J, Ciges, J.R, Alite, C, Bowring, J, Penades, J.R, Marina, A. 登録日 2015-07-02 公開日 2016-05-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Another look at the mechanism involving trimeric dUTPases in Staphylococcus aureus pathogenicity island induction involves novel players in the party. Nucleic Acids Res., 44, 2016
2V5N	STRUCTURE OF HUMAN IGF2R DOMAINS 11-12 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR 著者 Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. 登録日 2007-07-06 公開日 2007-12-11 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure and Functional Analysis of the Igf-II/Igf2R Interaction Embo J., 27, 2008
1KIL	Three-dimensional structure of the complexin/SNARE complex 分子名称: Complexin I SNARE-complex binding region, MAGNESIUM ION, SNAP-25 C-terminal SNARE motif, ... 著者 Chen, X, Tomchick, D, Kovrigin, E, Arac, D, Machius, M, Sudhof, T.C, Rizo, J. 登録日 2001-12-03 公開日 2002-03-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Three-dimensional structure of the complexin/SNARE complex. Neuron, 33, 2002
6GBI	Wnt signalling 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ly6/PLAUR domain-containing protein 6, ... 著者 Zhao, Y, Jones, E.Y. 登録日 2018-04-14 公開日 2018-08-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6. FEBS Lett., 592, 2018
2P5W	Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native diagonal binding geometry 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, CALCIUM ION, ... 著者 Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. 登録日 2007-03-16 公開日 2007-09-25 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry Protein Eng.Des.Sel., 20, 2007
2V9U	Rim domain of main porin from Mycobacteria smegmatis 分子名称: MSPA 著者 Grueninger, D, Ziegler, M.O.P, Koetter, J.W.A, Treiber, N, Schulze, M.-S, Schulz, G.E. 登録日 2007-08-27 公開日 2008-01-15 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Designed Protein-Protein Association. Science, 319, 2008
6G4N	Torpedo californica acetylcholinesterase bound to uncharged hybrid reactivator 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[4-[(7-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]butyl]-2-[(oxidanylamino)methyl]pyridin-3-ol, Acetylcholinesterase, ... 著者 Santoni, G, De la Mora, E, de Souza, J, Silman, I, Sussman, J, Baati, R, Weik, M, Nachon, F. 登録日 2018-03-28 公開日 2018-08-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. J. Med. Chem., 61, 2018
2P7K	Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes (hexagonal form) 分子名称: CITRIC ACID, Glyoxalase family protein 著者 Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. 登録日 2007-03-20 公開日 2007-07-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes. Biochemistry, 46, 2007
6G5F	Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1 分子名称: Botulinum neurotoxin type B, GLYCEROL, MALONATE ION, ... 著者 Masuyer, G, Elliot, M, Favre-Guilmard, C, Liu, S.M, Maignel, J, Beard, M, Carre, D, Kalinichev, M, Lezmi, S, Mir, I, Nicoleau, C, Palan, S, Perier, C, Raban, E, Dong, M, Krupp, J, Stenmark, P. 登録日 2018-03-29 公開日 2019-01-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Sci Adv, 5, 2019
6GCX	Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor 分子名称: 2-[[2-[[4-[[[3,4-bis(oxidanylidene)-2-[2-(propanoylamino)ethylamino]cyclobuten-1-yl]amino]methyl]phenyl]amino]-5-chloranyl-pyrimidin-4-yl]amino]-~{N}-methyl-benzamide, Focal adhesion kinase 1, SULFATE ION 著者 Yen-Pon, E, Li, B, Acebron-Garcia de Eulate, M, Tomkiewicz-Raulet, C, Dawson, J, Lietha, D, Frame, M.C, Coumoul, X, Garbay, C, Etheve-Quelquejeu, M, Chen, H. 登録日 2018-04-19 公開日 2019-05-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.553 Å) 主引用文献 Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. Acs Chem.Biol., 13, 2018
3MYM	Mutation of Methionine-86 in Dehaloperoxidase-hemoglobin: Effects of the Asp-His-Fe Triad in a 3/3 Globin 分子名称: CYANIDE ION, Dehaloperoxidase A, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 de Serrano, V.S, D'Antonio, E.L, Franzen, S, Bowden, E.F. 登録日 2010-05-10 公開日 2011-04-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Functional consequences of the creation of an Asp-His-Fe triad in a 3/3 globin. Biochemistry, 50, 2011
2P8B	Crystal structure of N-succinyl Arg/Lys racemase from Bacillus cereus ATCC 14579 complexed with N-succinyl Lys. 分子名称: MAGNESIUM ION, Mandelate racemase/muconate lactonizing enzyme family protein, N-SUCCINYL LYSINE 著者 Fedorov, A.A, Song, L, Fedorov, E.V, Gerlt, J.A, Almo, S.C. 登録日 2007-03-22 公開日 2007-07-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Prediction and assignment of function for a divergent N-succinyl amino acid racemase. Nat.Chem.Biol., 3, 2007
1FMF	REFINED SOLUTION STRUCTURE OF THE (13C,15N-LABELED) B12-BINDING SUBUNIT OF GLUTAMATE MUTASE FROM CLOSTRIDIUM TETANOMORPHUM 分子名称: METHYLASPARTATE MUTASE S CHAIN 著者 Hoffmann, B, Konrat, R, Tollinger, M, Huhta, M, Marsh, E.N.G, Kraeutler, B. 登録日 2000-08-17 公開日 2002-02-15 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A protein pre-organized to trap the nucleotide moiety of coenzyme B(12): refined solution structure of the B(12)-binding subunit of glutamate mutase from Clostridium tetanomorphum. Chembiochem, 2, 2001
3HXV	Crystal Structure of catalytic fragment of E. coli AlaRS in complex with GlySA 分子名称: 2-HYDROXYETHYL DISULFIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-(glycylsulfamoyl)adenosine, ... 著者 Guo, M, Yang, X.-L, Schimmel, P. 登録日 2009-06-22 公開日 2009-12-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature, 462, 2009
5QFN	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000324a 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-chloro-N-(1-hydroxy-2-methylpropan-2-yl)benzamide, Tyrosine-protein phosphatase non-receptor type 1 著者 Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. 登録日 2018-08-30 公開日 2018-10-10 最終更新日 2019-02-06 実験手法 X-RAY DIFFRACTION (1.675 Å) 主引用文献 An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
6FSP	Crystal structure of APRT from Thermus thermophilus 分子名称: PRPP-binding protein, adenine/guanine phosphoribosyltransferase 著者 Timofeev, V.I, Sinitsyna, E.V, Kostromina, M.A, Muravieva, T.I, Makarov, D.A, Mikheeva, O.O, Kuranova, I.P, Esipov, R.S. 登録日 2018-02-20 公開日 2019-03-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of APRT from Thermus thermophilus To Be Published
1FQ1	CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN-DEPENDENT KINASE INHIBITOR 3, ... 著者 Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D. 登録日 2000-09-01 公開日 2001-05-09 最終更新日 2018-03-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol.Cell, 7, 2001
3HXY	Crystal Structure of catalytic fragment of E. coli AlaRS in complex with AMPPCP, Ala-AMP and PCP 分子名称: 2-HYDROXYETHYL DISULFIDE, 5'-O-[(R)-{[(2S)-2-aminopropanoyl]oxy}(hydroxy)phosphoryl]adenosine, Alanyl-tRNA synthetase, ... 著者 Guo, M, Yang, X.-L, Schimmel, P. 登録日 2009-06-22 公開日 2009-12-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature, 462, 2009
2VLW	Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative. 分子名称: ACETATE ION, MUSCARINIC M1-TOXIN1, SULFATE ION 著者 Menez, R, Granata, V, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D, Stura, E.A. 登録日 2008-01-17 公開日 2008-10-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Different Interactions between Mt7 Toxin and the Human Muscarinic M1 Receptor in its Free and N-Methylscopolamine-Occupied States. Mol.Pharmacol., 74, 2008
3HNL	Crystal structure of the Cu-induced dimer of the engineered cyt cb562 variant RIDC-1 分子名称: CHLORIDE ION, COPPER (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Salgado, E.N, Lewis, R.A, Brodin, J, Tezcan, F.A. 登録日 2009-05-31 公開日 2010-02-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Metal templated design of protein interfaces. Proc.Natl.Acad.Sci.USA, 107, 2010
1KO9	Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1 分子名称: 8-oxoguanine DNA glycosylase, SULFATE ION 著者 Bjoras, M, Seeberg, E, Luna, L, Pearl, L.H, Barrett, T.E. 登録日 2001-12-20 公開日 2002-01-09 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. J.Mol.Biol., 317, 2002
7PAE	The crystal structure of Deltarasin in complex with PDE6D 分子名称: ACETIC ACID, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, deltarasin 著者 Beaumont, E, Williams, D. 登録日 2021-07-29 公開日 2022-06-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects. Blood Cancer J, 12, 2022
2H6D	Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain) 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2 著者 Littler, D.R, Walker, J.R, Wybenga-Groot, L, Newman, E.M, Butler-Cole, C, Mackenzie, F, Finerty, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2006-05-31 公開日 2006-06-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Acta Crystallogr.,Sect.F, 66, 2010
2OVY	Crystal structure of the catalytic domain of rat phosphodiesterase 10A 分子名称: 6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE, MAGNESIUM ION, Phosphodiesterase-10A, ... 著者 Pandit, J, Marr, E.S. 登録日 2007-02-15 公開日 2007-03-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors J.Med.Chem., 50, 2007

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