5VFT
 
 | | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 12, ... | | 著者 | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | | 登録日 | 2017-04-09 | | 公開日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (7 Å) | | 主引用文献 | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.
Nat Commun, 9, 2018
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2ZOQ
 | | Structural dissection of human mitogen-activated kinase ERK1 | | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Mitogen-activated protein kinase 3, SODIUM ION, ... | | 著者 | Kinoshita, T, Tada, T, Nakae, S, Yoshida, I. | | 登録日 | 2008-06-01 | | 公開日 | 2009-04-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Crystal structure of human mono-phosphorylated ERK1 at Tyr204
Biochem.Biophys.Res.Commun., 377, 2008
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5VFQ
 | | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 12, ... | | 著者 | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | | 登録日 | 2017-04-09 | | 公開日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.
Nat Commun, 9, 2018
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2ZFZ
 | | Crystal structure of the C-terminal domain hexamer of ArgR from Mycobacterium tuberculosis in complex with arginine | | 分子名称: | ARGININE, Arginine repressor, GUANIDINE | | 著者 | Cherney, L.T, Cherney, M.M, Garen, C.R, Lu, G.J, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2008-01-16 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.D, 64, 2008
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4LNF
 | | B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of GS-Q | | 分子名称: | GLUTAMINE, Glutamine synthetase, MAGNESIUM ION, ... | | 著者 | Schumacher, M.A, Chinnam, N, Tonthat, N, Fisher, S, Wray, L. | | 登録日 | 2013-07-11 | | 公開日 | 2013-11-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.949 Å) | | 主引用文献 | Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
J.Biol.Chem., 288, 2013
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8C2P
 | | FMDV 3D polymerase in complex with 3B3 | | 分子名称: | Protein 3B-3, RNA-directed RNA polymerase 3D-POL | | 著者 | Ferrer-Orta, C, Veraguer, N. | | 登録日 | 2022-12-22 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes.
Plos Pathog., 19, 2023
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8C1N
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6CTC
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1FX7
 | | CRYSTAL STRUCTURE OF THE IRON-DEPENDENT REGULATOR (IDER) FROM MYCOBACTERIUM TUBERCULOSIS | | 分子名称: | COBALT (II) ION, IRON-DEPENDENT REPRESSOR IDER, SULFATE ION | | 著者 | Feese, M.D, Ingason, B.P, Goranson-Siekierke, J, Holmes, R.K, Hol, W.J.G. | | 登録日 | 2000-09-25 | | 公開日 | 2001-03-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-A resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain.
J.Biol.Chem., 276, 2001
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8CAH
 | | Cryo-EM structure of native Otu2-bound ubiquitinated 43S pre-initiation complex | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | 著者 | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | 登録日 | 2023-01-24 | | 公開日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Nat Commun, 14, 2023
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8C4V
 | | Hantaan virus polymerase in replication elongation state | | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*AP*CP*UP*AP*CP*UP*A)-3'), RNA (5'-R(P*AP*GP*GP*AP*GP*UP*AP*UP*CP*CP*AP*CP*CP*GP*CP*AP*AP*GP*A)-3'), ... | | 著者 | Durieux trouilleton, Q, Arragain, B, Malet, H. | | 登録日 | 2023-01-04 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Nat Commun, 14, 2023
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8C4T
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8C4U
 | | Hantaan virus polymerase in replication pre-initiation state | | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*UP*AP*GP*GP*AP*GP*UP*AP*UP*CP*CP*AP*CP*CP*GP*CP*AP*AP*GP*A)-3'), RNA (5'-R(P*UP*UP*UP*UP*GP*CP*GP*GP*AP*GP*UP*AP*CP*UP*AP*CP*UP*A)-3'), ... | | 著者 | Durieux trouilleton, Q, Arragain, B, Malet, H. | | 登録日 | 2023-01-04 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Nat Commun, 14, 2023
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8C4S
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8CI5
 | | Structure of the SNV L protein bound to 5' RNA | | 分子名称: | RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*U)-3'), RNA-directed RNA polymerase L | | 著者 | Meier, K, Thorkelsson, S.R, Durieux Trouilleton, Q, Vogel, D, Yu, D, Kosinski, J, Cusack, S, Malet, H, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2023-02-08 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional characterization of the Sin Nombre virus L protein.
Plos Pathog., 19, 2023
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8CAZ
 | | empty 30S head | | 分子名称: | 16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S7, ... | | 著者 | Paternoga, H, Beckert, B, Wilson, D.N. | | 登録日 | 2023-01-24 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.11 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGI
 | | Pentacycline TP038 bound to the 30S head | | 分子名称: | 16S rRNA, 30S ribosomal protein S7, Large ribosomal subunit protein bL31A, ... | | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | 登録日 | 2023-02-04 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (1.89 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8T12
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8CF1
 | | Tetracycline bound to the 30S head | | 分子名称: | 16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S7, ... | | 著者 | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | | 登録日 | 2023-02-02 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (1.82 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8T13
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8CA7
 | | Omadacycline and spectinomycin bound to the 30S ribosomal subunit head | | 分子名称: | 16S rRNA, 30S ribosomal protein S7, MAGNESIUM ION, ... | | 著者 | Paternoga, H, Crowe-McAuliffe, C, Wilson, D.N. | | 登録日 | 2023-01-24 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.06 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CF8
 | | Eravacycline bound to the 30S head | | 分子名称: | 16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S7, ... | | 著者 | Paternoga, H, Koller, T.O, Beckert, B, Wilson, D.N. | | 登録日 | 2023-02-03 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8FOW
 | | Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib | | 分子名称: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... | | 著者 | Schonbrunn, E, Sun, L. | | 登録日 | 2023-01-03 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Nat Commun, 14, 2023
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4MO1
 | | Crystal structure of antitermination protein Q from bacteriophage lambda. Northeast Structural Genomics Consortium target OR18A. | | 分子名称: | Antitermination protein Q, BROMIDE ION, CHLORIDE ION, ... | | 著者 | Vorobiev, S, Su, M, Nickels, B, Seetharaman, J, Sahdev, S, Xiao, R, Kogan, S, Maglaqui, M, Wang, D, Everett, J.K, Acton, T.B, Ebright, R.H, Montelione, G.T, Hunt, J, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2013-09-11 | | 公開日 | 2013-09-25 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | Crystal structure of antitermination protein Q from bacteriophage lambda.
To be Published
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8BZS
 | | The crystal structure of glycogen phosphorylase in complex with baicalein | | 分子名称: | 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, Glycogen phosphorylase, muscle form, ... | | 著者 | Koulas, S.M, Mathomes, R, Hayes, J.M, Leonidas, D.D. | | 登録日 | 2022-12-15 | | 公開日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models.
Chem.Biol.Interact., 382, 2023
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