6AY6
 
 | | Naegleria fowleri CYP51-voriconazole complex | | 分子名称: | CYP51, sterol 14alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Debnath, A, Calvet, C.M, Jennings, G, Zhou, W, Aksenov, A, Luth, M, Abagyan, R, Nes, W.D, McKerrow, J.H, Podust, L.M. | | 登録日 | 2017-09-07 | | 公開日 | 2017-11-22 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).
PLoS Negl Trop Dis, 11, 2017
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1F4A
 | | E. COLI (LACZ) BETA-GALACTOSIDASE (NCS CONSTRAINED MONOMER-ORTHORHOMBIC) | | 分子名称: | BETA-GALACTOSIDASE, MAGNESIUM ION | | 著者 | Juers, D.H, Jacobson, R.H, Wigley, D, Zhang, X.J, Huber, R.E, Tronrud, D.E, Matthews, B.W. | | 登録日 | 2000-06-07 | | 公開日 | 2001-02-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation.
Protein Sci., 9, 2000
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6AY0
 | | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide | | 分子名称: | COPPER (II) ION, Peptidyl-glycine alpha-amidating monooxygenase | | 著者 | Maheshwari, S, Rudzka, K, Gabelli, S.B, Amzel, L.M. | | 登録日 | 2017-09-07 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Effects of copper occupancy on the conformational landscape of peptidylglycine alpha-hydroxylating monooxygenase.
Commun Biol, 1, 2018
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7F4V
 | | Cryo-EM structure of a primordial cyanobacterial photosystem I | | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | | 著者 | Kato, K, Hamaguchi, T, Nagao, R, Kawakami, K, Yonekura, K, Shen, J.R. | | 登録日 | 2021-06-21 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.04 Å) | | 主引用文献 | Structural basis for the absence of low-energy chlorophylls responsible for photoprotection from a primitive cyanobacterial PSI
Biorxiv, 2022
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7F0I
 | | phosphodiesterase-9A in complex with inhibitor 4b | | 分子名称: | 1-cyclopentyl-6-[[(2R)-1-(6-fluoranyl-2-azaspiro[3.3]heptan-2-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | | 著者 | Wu, Y, Huang, Y.Y, Luo, H.B. | | 登録日 | 2021-06-04 | | 公開日 | 2022-04-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.70000887 Å) | | 主引用文献 | Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis
J.Med.Chem., 64, 2021
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1KIU
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7EZJ
 | | Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response elements. | | 分子名称: | 12-mer DNA, Tumor protein p73, ZINC ION | | 著者 | Koley, T, Roy Chowdhury, S, Kumar, M, Kaur, P, Singh, T.P, Viadiu, H, Ethayathulla, A.S. | | 登録日 | 2021-06-01 | | 公開日 | 2022-04-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Deciphering the mechanism of p73 recognition of p53 response elements using the crystal structure of p73-DNA complexes and computational studies.
Int.J.Biol.Macromol., 206, 2022
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6B8Y
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1KI6
 | | CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE | | 分子名称: | 1',5'-ANHYDRO-2',3'-DIDEOXY-2'-(5-IODOURACIL-1-YL)-D-ABABINO-HEXITOL, SULFATE ION, THYMIDINE KINASE | | 著者 | Champness, J.N, Bennett, M.S, Wien, F, Herdewijn, P, Ostrowski, T, Summers, W.C, Sanderson, M.R. | | 登録日 | 1998-05-18 | | 公開日 | 1998-12-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
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1KME
 | | CRYSTAL STRUCTURE OF BACTERIORHODOPSIN CRYSTALLIZED FROM BICELLES | | 分子名称: | 2,10,23-TRIMETHYL-TETRACOSANE, Bacteriorhodopsin, RETINAL, ... | | 著者 | Faham, S, Bowie, J.U. | | 登録日 | 2001-12-14 | | 公開日 | 2002-02-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Bicelle crystallization: a new method for crystallizing membrane proteins yields a monomeric bacteriorhodopsin structure.
J.Mol.Biol., 316, 2002
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6BD9
 | | Saccharomyces cerevisiae acetohydroxyacid synthase | | 分子名称: | Acetolactate synthase catalytic subunit, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Guddat, L.W, Lonhienne, T. | | 登録日 | 2017-10-22 | | 公開日 | 2017-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.982 Å) | | 主引用文献 | High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism
Chemistryselect, 2017
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7F30
 | | Crystal structure of OxdB E85A in complex with Z-2- (3-bromophenyl) propanal oxime | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Phenylacetaldoxime dehydratase, Z-2-(3-bromophenyl) propanal oxime | | 著者 | Muraki, N, Matsui, D, Asano, Y, Aono, S. | | 登録日 | 2021-06-15 | | 公開日 | 2022-04-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structural analysis of aldoxime dehydratase from Bacillus sp. OxB-1: Importance of surface residues in optimization for crystallization.
J.Inorg.Biochem., 230, 2022
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1G27
 | | CRYSTAL STRUCTURE OF E.COLI POLYPEPTIDE DEFORMYLASE COMPLEXED WITH THE INHIBITOR BB-3497 | | 分子名称: | 2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEXANOIC ACID (1-DIMETHYLCARBAMOYL-2,2-DIMETHYL-PROPYL)-AMIDE, NICKEL (II) ION, POLYPEPTIDE DEFORMYLASE | | 著者 | Clements, J.M, Beckett, P, Brown, A, Catlin, C, Lobell, M, Palan, S, Thomas, W, Whittaker, M, Baker, P.J, Rodgers, H.F, Barynin, V, Rice, D.W, Hunter, M.G. | | 登録日 | 2000-10-17 | | 公開日 | 2001-10-17 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
Antimicrob.Agents Chemother., 45, 2001
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7F2Z
 | | Crystal structure of OxdB E85A mutant (form II) | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Phenylacetaldoxime dehydratase | | 著者 | Muraki, N, Matsui, D, Asano, Y, Aono, S. | | 登録日 | 2021-06-15 | | 公開日 | 2022-04-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structural analysis of aldoxime dehydratase from Bacillus sp. OxB-1: Importance of surface residues in optimization for crystallization.
J.Inorg.Biochem., 230, 2022
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6AO6
 | | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) | | 分子名称: | COPPER (II) ION, GLYCEROL, NICKEL (II) ION, ... | | 著者 | Maheshwari, S, Rudzka, K, Gabelli, S.B, Amzel, L.M. | | 登録日 | 2017-08-15 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Effects of copper occupancy on the conformational landscape of peptidylglycine alpha-hydroxylating monooxygenase.
Commun Biol, 1, 2018
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1G2J
 | | RNA OCTAMER R(CCCP*GGGG) CONTAINING PHENYL RIBONUCLEOTIDE | | 分子名称: | 5'-R(*CP*CP*CP*(PYY)P*GP*GP*GP*G)-3', CALCIUM ION | | 著者 | Minasov, G, Matulic-Adamic, J, Wilds, C.J, Haeberli, P, Usman, N, Beigelman, L, Egli, M. | | 登録日 | 2000-10-20 | | 公開日 | 2000-12-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines.
RNA, 6, 2000
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7FEV
 | | Crystal structure of Old Yellow Enzyme6 (OYE6) | | 分子名称: | FLAVIN MONONUCLEOTIDE, FMN binding | | 著者 | Singh, Y, Sharma, R, Mishra, M, Verma, P.K, Saxena, A.K. | | 登録日 | 2021-07-21 | | 公開日 | 2022-04-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.594 Å) | | 主引用文献 | Crystal structure of ArOYE6 reveals a novel C-terminal helical extension and mechanistic insights into the distinct class III OYEs from pathogenic fungi.
Febs J., 289, 2022
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7FJN
 | | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ... | | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | | 登録日 | 2021-08-04 | | 公開日 | 2022-04-27 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants.
Iscience, 25, 2022
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7F5W
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1KUU
 | | CRYSTAL STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM CONSERVED PROTEIN MTH1020 REVEALS AN NTN-HYDROLASE FOLD | | 分子名称: | conserved protein | | 著者 | Saridakis, V, Christendat, D, Thygesen, A, Arrowsmith, C.H, Edwards, A.M, Pai, E.F. | | 登録日 | 2002-01-22 | | 公開日 | 2002-05-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM CONSERVED PROTEIN MTH1020 REVEALS AN NTN-HYDROLASE FOLD
PROTEINS: STRUCT.,FUNCT.,GENET., 48, 2002
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1G3I
 | | CRYSTAL STRUCTURE OF THE HSLUV PROTEASE-CHAPERONE COMPLEX | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT HSLU PROTEASE ATP-BINDING SUBUNIT HSLU, ATP-DEPENDENT PROTEASE HSLV | | 著者 | Sousa, M.C, Trame, C.B, Tsuruta, H, Wilbanks, S.M, Reddy, V.S, McKay, D.B. | | 登録日 | 2000-10-24 | | 公開日 | 2000-11-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | | 主引用文献 | Crystal and solution structures of an HslUV protease-chaperone complex.
Cell(Cambridge,Mass.), 103, 2000
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7EQ7
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6ASW
 | | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.0 | | 分子名称: | 2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATE, DNA (27-MER), DNA (5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*(DDG))-3'), ... | | 著者 | Martinez, S.E, Das, K, Arnold, E. | | 登録日 | 2017-08-25 | | 公開日 | 2018-08-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.605 Å) | | 主引用文献 | Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes.
Protein Sci., 28, 2019
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1GCZ
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1G87
 | | THE CRYSTAL STRUCTURE OF ENDOGLUCANASE 9G FROM CLOSTRIDIUM CELLULOLYTICUM | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, ENDOCELLULASE 9G, ... | | 著者 | Mandelman, D, Belaich, A, Belaich, J.P, Aghajari, N, Driguez, H, Haser, R. | | 登録日 | 2000-11-16 | | 公開日 | 2003-07-15 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | X-Ray Crystal Structure of the Multidomain Endoglucanase Cel9G from Clostridium
cellulolyticum Complexed with Natural and Synthetic Cello-Oligosaccharides
J.BACTERIOL., 185, 2003
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