6B8Y

TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Summary for 6B8Y

• Entry DOI: 10.2210/pdb6b8y/pdb
• Descriptor: TGF-beta receptor type-1, N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: alk5, kinase domain, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P36897
• Total number of polymer chains: 1
• Total formula weight: 35539.77

Authors

Sheriff, S. (deposition date: 2017-10-09, release date: 2018-02-07, Last modification date: 2023-10-04)

• Primary citation: Harikrishnan, L.S.,Warrier, J.,Tebben, A.J.,Tonukunuru, G.,Madduri, S.R.,Baligar, V.,Mannoori, R.,Seshadri, B.,Rahaman, H.,Arunachalam, P.N.,Dikundwar, A.G.,Fink, B.E.,Fargnoli, J.,Fereshteh, M.,Fan, Y.,Lippy, J.,Ho, C.P.,Wautlet, B.,Sheriff, S.,Ruzanov, M.,Borzilleri, R.M.; Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF beta RI).; Bioorg. Med. Chem., 26:1026-1034, 2018; PubMed: 29422332; DOI: 10.1016/j.bmc.2018.01.014

Experimental method

X-RAY DIFFRACTION (1.65 Å)