1G27

CRYSTAL STRUCTURE OF E.COLI POLYPEPTIDE DEFORMYLASE COMPLEXED WITH THE INHIBITOR BB-3497

Summary for 1G27

Related1G2A
DescriptorPOLYPEPTIDE DEFORMYLASE, NICKEL (II) ION, 2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEXANOIC ACID (1-DIMETHYLCARBAMOYL-2,2-DIMETHYL-PROPYL)-AMIDE, ... (4 entities in total)
Functional Keywordsbb-3497, inhibition, polypeptide deformylase, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains3
Total molecular weight58843.13
Authors
Clements, J.M.,Beckett, P.,Brown, A.,Catlin, C.,Lobell, M.,Palan, S.,Thomas, W.,Whittaker, M.,Baker, P.J.,Rodgers, H.F.,Barynin, V.,Rice, D.W.,Hunter, M.G. (deposition date: 2000-10-17, release date: 2001-10-17, Last modification date: 2017-10-04)
Primary citation
Clements, J.M.,Beckett, R.P.,Brown, A.,Catlin, G.,Lobell, M.,Palan, S.,Thomas, W.,Whittaker, M.,Wood, S.,Salama, S.,Baker, P.J.,Rodgers, H.F.,Barynin, V.,Rice, D.W.,Hunter, M.G.
Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
Antimicrob.Agents Chemother., 45:563-570, 2001
PubMed: 11158755 (PDB entries with the same primary citation)
DOI: 10.1128/AAC.45.2.563-570.2001
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers190.4%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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