6GGF
| |
2X9D
| |
7LS1
| 80S ribosome from mouse bound to eEF2 (Class II) | 分子名称: | 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | 登録日 | 2021-02-17 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Nat Commun, 12, 2021
|
|
7LS2
| 80S ribosome from mouse bound to eEF2 (Class I) | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | 登録日 | 2021-02-17 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Nat Commun, 12, 2021
|
|
2VKE
| |
2VG7
| Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors | 分子名称: | O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-iodophenyl)thiocarbamate, P51 RT, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | 著者 | Spallarossa, A, Cesarini, S, Ranise, A, Ponassi, M, Unge, T, Bolognesi, M. | 登録日 | 2007-11-08 | 公開日 | 2007-12-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Crystal Structures of HIV-1 Reverse Transcriptase Complexes with Thiocarbamate Non-Nucleoside Inhibitors. Biochem.Biophys.Res.Commun., 365, 2008
|
|
5LSF
| Sacbrood honeybee virus | 分子名称: | CALCIUM ION, VP1, VP2, ... | 著者 | Plevka, P, Veselikova, M. | 登録日 | 2016-08-26 | 公開日 | 2018-08-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Virion structure and genome delivery mechanism of sacbrood honeybee virus. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6OWI
| Crystal structure of MYST acetyltransferase domain in complex with inhibitor 85 | 分子名称: | GLYCEROL, Histone acetyltransferase KAT8, N'-[(2-fluorophenyl)sulfonyl]benzohydrazide, ... | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-05-09 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
|
|
5LGT
| Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 15 | 分子名称: | 4-methyl-~{N}-[2-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... | 著者 | Mattevi, A, Ciossani, G. | 登録日 | 2016-07-08 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J. Med. Chem., 60, 2017
|
|
6ODB
| Crystal structure of HDAC8 in complex with compound 3 | 分子名称: | GLYCEROL, Histone deacetylase 8, N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide, ... | 著者 | Zheng, X, Conti, C, Caravella, J, Zablocki, M.-M, Bair, K, Barczak, N, Han, B, Lancia Jr, D, Liu, C, Martin, M, Ng, P.Y, Rudnitskaya, A, Thomason, J.J, Garcia-Dancey, R, Hardy, C, Lahdenranta, J, Leng, C, Li, P, Pardo, E, Saldahna, A, Tan, T, Toms, A.V, Yao, L, Zhang, C. | 登録日 | 2019-03-26 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors To Be Published
|
|
5LNK
| Entire ovine respiratory complex I | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 4'-PHOSPHOPANTETHEINE, ... | 著者 | Fiedorczuk, K, Letts, J.A, Kaszuba, K, Sazanov, L.A. | 登録日 | 2016-08-04 | 公開日 | 2016-11-23 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Atomic structure of the entire mammalian mitochondrial complex I. Nature, 538, 2016
|
|
6OIN
| Crystal structure of MYST acetyltransferase domain in complex with inhibitor CTX-124143 | 分子名称: | 2-fluoro-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-04-09 | 公開日 | 2019-07-03 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
|
|
6ON2
| Lon Protease from Yersinia pestis with Y2853 substrate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent protease La, ... | 著者 | Shin, M, Asmita, A, Puchades, C, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. | 登録日 | 2019-04-19 | 公開日 | 2019-05-01 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
|
|
6OJ5
| In situ structure of rotavirus VP1 RNA-dependent RNA polymerase (TLP_RNA) | 分子名称: | Inner capsid protein VP2, RNA-directed RNA polymerase | 著者 | Jenni, S, Salgado, E.N, Herrmann, T, Li, Z, Grant, T, Grigorieff, N, Trapani, S, Estrozi, L.F, Harrison, S.C. | 登録日 | 2019-04-10 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase. J.Mol.Biol., 431, 2019
|
|
6O6V
| |
1VSR
| VERY SHORT PATCH REPAIR (VSR) ENDONUCLEASE FROM ESCHERICHIA COLI | 分子名称: | PROTEIN (VSR ENDONUCLEASE), ZINC ION | 著者 | Tsutakawa, S.E, Muto, T, Jingami, H, Kunishima, N, Ariyoshi, M, Kohda, D, Nakagawa, M, Morikawa, K. | 登録日 | 1999-02-13 | 公開日 | 1999-10-27 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystallographic and functional studies of very short patch repair endonuclease. Mol.Cell, 3, 1999
|
|
5LPJ
| |
1VEW
| MANGANESE SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI | 分子名称: | HYDROXIDE ION, MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE | 著者 | Edwards, R.A, Baker, H.M, Whittaker, M.M, Whittaker, J.W, Jameson, G.B, Baker, E.N. | 登録日 | 1998-01-20 | 公開日 | 1998-05-27 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of Escherichia coli manganese superoxide dismutase at 2.1-angstrom resolution. J.Biol.Inorg.Chem., 3, 1998
|
|
6OJ4
| In situ structure of rotavirus VP1 RNA-dependent RNA polymerase (DLP) | 分子名称: | Inner capsid protein VP2, RNA-directed RNA polymerase | 著者 | Jenni, S, Salgado, E.N, Herrmann, T, Li, Z, Grant, T, Grigorieff, N, Trapani, S, Estrozi, L.F, Harrison, S.C. | 登録日 | 2019-04-10 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase. J.Mol.Biol., 431, 2019
|
|
5LPK
| |
6ODC
| Crystal structure of HDAC8 in complex with compound 30 | 分子名称: | (2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide, 1,2-ETHANEDIOL, Histone deacetylase 8, ... | 著者 | Zheng, X, Conti, C, Caravella, J, Zablocki, M.-M, Bair, K, Barczak, N, Han, B, Lancia Jr, D, Liu, C, Martin, M, Ng, P.Y, Rudnitskaya, A, Thomason, J.J, Garcia-Dancey, R, Hardy, C, Lahdenranta, J, Leng, C, Li, P, Pardo, E, Saldahna, A, Tan, T, Toms, A.V, Yao, L, Zhang, C. | 登録日 | 2019-03-26 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors To Be Published
|
|
6OIO
| Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 | 分子名称: | Histone acetyltransferase KAT8, N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, ZINC ION | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-04-09 | 公開日 | 2019-07-03 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
|
|
5M35
| |
5LPL
| Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM3c | 分子名称: | CREB-binding protein, ~{N}-[(1~{R},2~{R})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide | 著者 | Wohlwend, D, Huegle, M. | 登録日 | 2016-08-13 | 公開日 | 2017-08-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5LGU
| Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 34 | 分子名称: | 4-methyl-~{N}-[2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... | 著者 | Mattevi, A, Ciossani, G. | 登録日 | 2016-07-08 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J. Med. Chem., 60, 2017
|
|