5LPL

Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM3c

Summary for 5LPL

• Entry DOI: 10.2210/pdb5lpl/pdb
• Related: 5NRW
• Descriptor: CREB-binding protein, ~{N}-[(1~{R},2~{R})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide (3 entities in total)
• Functional Keywords: bromodomain, protein-inhibitor complex, epigenetics, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 1
• Total formula weight: 14598.21

Authors

Wohlwend, D.,Huegle, M. (deposition date: 2016-08-13, release date: 2017-08-16, Last modification date: 2017-10-11)

• Primary citation: Hugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D.; Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.; Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017; PubMed: 28766825; DOI: 10.1002/anie.201705516

Experimental method

X-RAY DIFFRACTION (1.65 Å)