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5MRC
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BU of 5mrc by Molmil
Structure of the yeast mitochondrial ribosome - Class A
分子名称: 15S ribosomal RNA, 21S ribosomal RNA, GUANOSINE-5'-DIPHOSPHATE, ...
著者Desai, N, Brown, A, Amunts, A, Ramakrishnan, V.
登録日2016-12-22
公開日2017-02-15
最終更新日2018-02-07
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献The structure of the yeast mitochondrial ribosome.
Science, 355, 2017
5MRE
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BU of 5mre by Molmil
Structure of the yeast mitochondrial ribosome - Class B
分子名称: 15S ribosomal RNA, 21S ribosomal RNA, GUANOSINE-5'-DIPHOSPHATE, ...
著者Desai, N, Brown, A, Amunts, A, Ramakrishnan, V.
登録日2016-12-22
公開日2017-02-15
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献The structure of the yeast mitochondrial ribosome.
Science, 355, 2017
6H1C
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BU of 6h1c by Molmil
Structure of Ferric uptake regulator from Pseudomonas aeruginosa with manganese.
分子名称: Ferric uptake regulation protein, MANGANESE (II) ION, ZINC ION
著者Nader, S, Perard, J, Carpentier, P, Michaud-Soret, I, Crouzy, S.
登録日2018-07-11
公開日2019-07-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Ferric uptake regulator with Mn and Zn form Pseudomonas aeruginosa
To Be Published
6OM7
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BU of 6om7 by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Li, W, Cate, J.H.D.
登録日2019-04-18
公開日2019-06-19
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6QZP
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BU of 6qzp by Molmil
High-resolution cryo-EM structure of the human 80S ribosome
分子名称: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ...
著者Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P.
登録日2019-03-12
公開日2019-04-24
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
4UEL
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BU of 4uel by Molmil
UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain
分子名称: POLYUBIQUITIN-B, PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
著者Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
登録日2014-12-18
公開日2015-03-04
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
6O22
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BU of 6o22 by Molmil
Structure of Asf1-H3:H4-Rtt109-Vps75 histone chaperone-lysine acetyltransferase complex with the histone substrate.
分子名称: Histone H3.2, Histone H4, Histone acetyltransferase RTT109, ...
著者Danilenko, N, Carlomagno, T, Kirkpatrick, J.P.
登録日2019-02-22
公開日2019-07-31
最終更新日2024-05-01
実験手法SOLUTION NMR, SOLUTION SCATTERING
主引用文献Histone chaperone exploits intrinsic disorder to switch acetylation specificity.
Nat Commun, 10, 2019
4UEM
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BU of 4uem by Molmil
UCH-L5 in complex with the RPN13 DEUBAD domain
分子名称: PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
著者Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
登録日2014-12-18
公開日2015-03-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
5O9B
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BU of 5o9b by Molmil
Solution NMR structure of human GATA2 C-terminal zinc finger domain
分子名称: Endothelial transcription factor GATA-2, ZINC ION
著者Nurmohamed, S.S, Broadhurst, R.W, May, G, Enver, T.
登録日2017-06-16
公開日2019-02-06
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Solution NMR structure of human GATA2 C-terminal zinc finger domain
To Be Published
5G49
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BU of 5g49 by Molmil
Crystal structure of the Arabodopsis thaliana histone-fold dimer L1L NF-YC3
分子名称: ACETATE ION, CALCIUM ION, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT B-6, ...
著者Gnesutta, N, Saad, D, Chaves-Sanjuan, A, Mantovani, R, Nardini, M.
登録日2016-05-06
公開日2016-12-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the Arabidopsis thaliana L1L/NF-YC3 Histone-fold Dimer Reveals Specificities of the LEC1 Family of NF-Y Subunits in Plants.
Mol Plant, 10, 2017
2N8G
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BU of 2n8g by Molmil
NMR Structure of the homeodomain transcription factor Gbx1[E23R,R58E] from Homo sapiens
分子名称: Homeobox protein GBX-1
著者Proudfoot, A.K, Serrano, P, Geralt, M, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL)
登録日2015-10-15
公開日2015-10-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR Structure of the homeodomain transcription factor Gbx1[E23R,R58E] from Homo sapiens
To be Published
2KC8
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BU of 2kc8 by Molmil
Structure of E. coli toxin RelE (R81A/R83A) mutant in complex with antitoxin RelBc (K47-L79) peptide
分子名称: Antitoxin RelB, Toxin relE
著者Li, G, Zhang, Y, Inouye, M, Ikura, M.
登録日2008-12-17
公開日2009-03-17
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site.
J.Biol.Chem., 284, 2009
2KC9
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BU of 2kc9 by Molmil
Structure of E. coli toxin RelE (R81A/R83A) mutant in the free state
分子名称: Toxin relE
著者Li, G, Zhang, Y, Inouye, M, Ikura, M.
登録日2008-12-17
公開日2009-03-17
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site.
J.Biol.Chem., 284, 2009
7QH5
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BU of 7qh5 by Molmil
The crystal structure of the sigma factor SigG1 from Streptomyces tsukubaensis NRRL18488
分子名称: GLYCEROL, RNA polymerase sigma factor
著者Lourenco, F, Leite, J.P, Gales, L.
登録日2021-12-10
公開日2022-12-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG.
J.Struct.Biol., 215, 2023
6ZVH
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BU of 6zvh by Molmil
EDF1-ribosome complex
分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R.
登録日2020-07-24
公開日2020-08-19
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献EDF1 coordinates cellular responses to ribosome collisions.
Elife, 9, 2020
8FMU
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BU of 8fmu by Molmil
Crystal structure of human Brachyury G177D variant in complex with SJF-4601
分子名称: N-(3-chloro-4-fluorophenyl)-3-[4-(dimethylamino)butanamido]-4-methoxybenzamide, T-box transcription factor T
著者Bebenek, A, Linhares, B, Jaime-Figueroa, S, Butrin, A, Crews, C.
登録日2022-12-24
公開日2024-02-28
最終更新日2024-09-18
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury.
Angew.Chem.Int.Ed.Engl., 63, 2024
8U8J
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BU of 8u8j by Molmil
Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #16
分子名称: (4M)-4-{(4R)-3-[(2S)-2-methylbutyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1
著者Anderson, J.W, Vigers, G.P.
登録日2023-09-18
公開日2024-03-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2.
Elife, 12, 2024
8U8K
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BU of 8u8k by Molmil
Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #8
分子名称: (4M)-4-{(4S)-3-[(2-chloropyridin-3-yl)methyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(oxan-4-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1
著者Anderson, J.W, Vigers, G.P.
登録日2023-09-18
公開日2024-03-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2.
Elife, 12, 2024
6MBZ
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BU of 6mbz by Molmil
Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
6LSF
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BU of 6lsf by Molmil
Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6RA/C2S6RB form)
分子名称: Genome polyprotein, RNA (35-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3'), ...
著者Wang, M, Shu, B, Jing, X, Gong, P.
登録日2020-01-17
公開日2020-04-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.152 Å)
主引用文献Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures.
Nat Commun, 11, 2020
6MBW
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BU of 6mbw by Molmil
Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019
6J6V
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BU of 6j6v by Molmil
Crystal structure of heat shock factor 4-DBD
分子名称: Heat shock factor protein 4, NITRATE ION, SODIUM ION
著者Guo, L, Xiao, Z.Y, Wang, S, Liu, W.
登録日2019-01-16
公開日2020-01-22
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure of heat shock factor 4-DBD at 1.20 Angstroms resolution.
To Be Published
8BPA
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BU of 8bpa by Molmil
Cryo-EM structure of the human SIN3B histone deacetylase complex at 3.7 Angstrom
分子名称: CALCIUM ION, Histone deacetylase 2, Isoform 2 of Paired amphipathic helix protein Sin3b, ...
著者Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C.
登録日2022-11-16
公開日2023-05-10
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.
Nat Commun, 14, 2023
6FF7
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BU of 6ff7 by Molmil
human Bact spliceosome core structure
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, BUD13 homolog, ...
著者Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H.
登録日2018-01-03
公開日2019-03-13
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
6J6W
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BU of 6j6w by Molmil
Mutant K23N of heat shock factor 4-DBD
分子名称: Heat shock factor protein 4, NITRATE ION, SODIUM ION
著者Xiao, Z.Y, Cui, L.W, Wang, S, Liu, W.
登録日2019-01-16
公開日2020-01-22
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.693 Å)
主引用文献Structure of the mutant K23N of heat shock factor 4-DBD at 1.69 Angstroms resolution.
To Be Published

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件を2024-10-09に公開中

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