PDB: 47038 件ウェブページステータス検索Chemie searchBIRD

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8FSK	LSD1-CoREST in complex with T18, short soaking 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-(3-benzamidophenyl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) 著者 Caroli, J, Mattevi, A. 登録日 2023-01-10 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To Be Published
8AP4	Structure of Escherischia coli heat shock protein Hsp15 in complex with ribosomal 50S subunits bearing peptidyl-tRNA 分子名称: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Safdari, H.A, Wilson, D.N. 登録日 2022-08-09 公開日 2022-11-16 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit bearing peptidyl-tRNA. Nucleic Acids Res., 50, 2022
4L5I	Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition 分子名称: Transcriptional regulator LsrR 著者 Ryu, K.S, Ha, J.H, Eo, Y. 登録日 2013-06-11 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J.Am.Chem.Soc., 135, 2013
8ANA	Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit 分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, 50S ribosomal protein L13, ... 著者 Koller, T.O, Morici, M, Wilson, D.N. 登録日 2022-08-05 公開日 2023-03-08 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Structural basis for translation inhibition by the glycosylated drosocin peptide. Nat.Chem.Biol., 19, 2023
4L5J	Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition 分子名称: 5-O-phosphono-alpha-D-ribofuranose, Transcriptional regulator LsrR 著者 Ryu, K.S, Ha, J.H, Eo, Y. 登録日 2013-06-11 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J.Am.Chem.Soc., 135, 2013
8QU8	PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1 分子名称: (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... 著者 Fischer, G, Peter, D, Arce-Solano, S. 登録日 2023-10-14 公開日 2023-12-06 最終更新日 2024-10-02 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Targeting cancer with small-molecule pan-KRAS degraders. Science, 385, 2024
5ABA	Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149 分子名称: 1-{1-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl piperidin-4-yl}piperidin-4-ol], CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C. 登録日 2015-08-04 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
5AB9	Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole 分子名称: 7-ethyl-3-(piperidin-4-yl)-1H-indole, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ... 著者 Joerger, A.C. 登録日 2015-08-04 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
5A7B	Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211 分子名称: 2-[[4-(diethylamino)piperidin-1-yl]methyl]-6-ethynyl-4-(3-phenoxyprop-1-ynyl)phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C. 登録日 2015-07-03 公開日 2015-09-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere. Acs Chem.Biol., 10, 2015
7YHJ	Effector binding domain of LysR-Type transcription factor LrhA from E. coli 分子名称: DI(HYDROXYETHYL)ETHER, Probable HTH-type transcriptional regulator LrhA, SULFATE ION 著者 Xie, C, Jiang, X. 登録日 2022-07-13 公開日 2022-08-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.237 Å) 主引用文献 Effector binding domain of LysR-Type transcription factor LrhA from E. coli To Be Published
5NDW	Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. 登録日 2017-03-09 公開日 2017-12-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NDG	Crystal structure of geneticin (G418) bound to the yeast 80S ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. 登録日 2017-03-08 公開日 2017-12-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8C91	Cryo-EM captures early ribosome assembly in action 分子名称: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Lauer, S, Nikolay, R, Qin, B. 登録日 2023-01-21 公開日 2023-04-05 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.19 Å) 主引用文献 Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
8C8Y	Cryo-EM captures early ribosome assembly in action 分子名称: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Lauer, S, Nikolay, R, Qin, B. 登録日 2023-01-21 公開日 2023-04-05 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
5AOJ	Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid 分子名称: 2-hydroxy-3,5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ... 著者 Joerger, A.C, Baud, M.G, Bauer, M.R, Fersht, A.R. 登録日 2015-09-10 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
8C8X	Cryo-EM captures early ribosome assembly in action 分子名称: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Lauer, S, Nikolay, R, Qin, B. 登録日 2023-01-21 公開日 2023-04-05 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.93 Å) 主引用文献 Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
5AOL	Structure of the p53 cancer mutant Y220C with bound 3-bromo-5-(trifluoromethyl)benzene-1,2-diamine 分子名称: 3-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Harbrecht, H. 登録日 2015-09-10 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
5AOK	Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan7099 分子名称: 5-[2-cyclopropyl-5-(1H-pyrrol-1-yl)-1,3-oxazol-4-yl]-1H-1,2,3,4-tetrazole, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ... 著者 Joerger, A.C. 登録日 2015-09-10 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
5AOM	Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883 分子名称: CELLULAR TUMOR ANTIGEN P53, GLYCEROL, N-(5-chloranyl-2-oxidanyl-phenyl)piperidine-4-carboxamide, ... 著者 Joerger, A.C, Boeckler, F.M, Wilcken, R. 登録日 2015-09-10 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
4NN1	Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis 分子名称: Transcriptional regulator 著者 Kumar, N, Radhakrishnan, A, Chou, T.-H, Yu, E. 登録日 2013-11-15 公開日 2014-02-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis. Protein Sci., 23, 2014
5TM0	Solution NMR structures of two alternative conformations of E. coli tryptophan repressor in dynamic equilibrium 分子名称: Trp operon repressor 著者 Harish, B, Swapna, G.V.T, Kornhaber, G.J, Montelione, G.T, Carey, J, Northeast Structural Genomics Consortium (NESG) 登録日 2016-10-12 公開日 2017-10-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Multiple helical conformations of the helix-turn-helix region revealed by NOE-restrained MD simulations of tryptophan aporepressor, TrpR. Proteins, 85, 2017
5AOI	Structure of the p53 cancer mutant Y220C in complex with an indole- based small molecule 分子名称: 2-(5-BROMO-7-ETHYL-2-METHYL-1H-INDOLE-3-YL)ETHAN-1-AMIN, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ... 著者 Joerger, A.C, Wilcken, R. 登録日 2015-09-10 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
4BKX	The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex 分子名称: ACETATE ION, HISTONE DEACETYLASE 1, METASTASIS-ASSOCIATED PROTEIN MTA1, ... 著者 Millard, C.J, Watson, P.J, Celardo, I, Gordiyenko, Y, Cowley, S.M, Robinson, C.V, Fairall, L, Schwabe, J.W.R. 登録日 2013-04-30 公開日 2013-07-03 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates. Mol.Cell, 51, 2013
8CDR	Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. 登録日 2023-01-31 公開日 2023-09-20 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.04 Å) 主引用文献 mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
8CDL	80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. 登録日 2023-01-31 公開日 2023-09-20 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.72 Å) 主引用文献 mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024

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