6NRD
 
 | | hTRiC-hPFD Class4 | | 分子名称: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | | 著者 | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | 登録日 | 2019-01-23 | | 公開日 | 2019-06-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | | 主引用文献 | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
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5HN0
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 | | 分子名称: | (6-hydroxybiphenyl-3-yl)acetic acid, RNA-directed RNA polymerase NS5, ZINC ION | | 著者 | Noble, C.G. | | 登録日 | 2016-01-17 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
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7CRQ
 | | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) | | 分子名称: | DNA (168-MER), Histone H2A, Histone H2B, ... | | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | | 登録日 | 2020-08-14 | | 公開日 | 2020-10-21 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
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7CRP
 | | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode) | | 分子名称: | DNA (168-MER), Histone H2A, Histone H2B, ... | | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | | 登録日 | 2020-08-14 | | 公開日 | 2020-10-21 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
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7K79
 | | CBF3 | | 分子名称: | Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1 | | 著者 | Ruifang, G, Yawen, B. | | 登録日 | 2020-09-22 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation.
Nat Commun, 12, 2021
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4L4Y
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4L4Z
 | | Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition | | 分子名称: | (2S)-2,3,3-trihydroxy-4-oxopentyl dihydrogen phosphate, Transcriptional regulator LsrR | | 著者 | Ryu, K.S, Ha, J.H, Eo, Y. | | 登録日 | 2013-06-10 | | 公開日 | 2013-11-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition.
J.Am.Chem.Soc., 135, 2013
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4L50
 | | Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition | | 分子名称: | (2S)-2,3,3-trihydroxy-6-methyl-4-oxoheptyl dihydrogen phosphate, Transcriptional regulator LsrR | | 著者 | Ryu, K.S, Ha, J.H, Eo, Y. | | 登録日 | 2013-06-10 | | 公開日 | 2013-11-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition.
J.Am.Chem.Soc., 135, 2013
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4L5I
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9NB9
 | | Viral protein DP71L in complex with phosphorylated eIF2alpha (NTD) and protein phosphatase 1A (D64A), stabilized by G-actin/DNAseI | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Reineke, L.C, Dalwadi, U, Croll, T, Arthur, C, Lee, D.J, Frost, A, Costa-Mattioli, M. | | 登録日 | 2025-02-13 | | 公開日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction.
Biorxiv, 2025
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5H83
 | | HETEROYOHIMBINE SYNTHASE HYS FROM CATHARANTHUS ROSEUS - APO FORM | | 分子名称: | ZINC ION, heteroyohimbine synthase HYS | | 著者 | Stavrinides, A, Tatsis, E.C, Caputi, L, Foureau, E, Stevenson, C.E.M, Lawson, D.M, Courdavault, V, O'Connor, S.E. | | 登録日 | 2015-12-23 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.
Nat Commun, 7, 2016
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9CG9
 | | Cryo-EM structure of an HMGB1 box bound to nucleosome at SHL-2 | | 分子名称: | High mobility group protein B1, Histone H2A type 1, Histone H2B, ... | | 著者 | Chio, U.S, Saunders, H.S, Narlikar, G.J, Cheng, Y. | | 登録日 | 2024-06-28 | | 公開日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Competition between HMGB1 and H1 on nucleosomes tunes dynamics within condensed chromatin
To Be Published
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5X22
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5J7J
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2ZY9
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7BWD
 | | Structure of Dot1L-H2BK34ub Nucleosome Complex | | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Lou, Z.Y, Liu, L, Cao, L, Ai, H.S, Sun, Z.X. | | 登録日 | 2020-04-14 | | 公開日 | 2021-04-14 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | | 主引用文献 | Structure of the Dot1L-H2BK34ub Nucleosome Complex Reveals an Unprecedented Crosstalk Activation Mechanism through Nucleosome Shape Distortion
To Be Published
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6HYI
 | | Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A resolution in complex with inosine | | 分子名称: | INOSINE, Protein kinase A regulatory subunit | | 著者 | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | | 登録日 | 2018-10-22 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.39944851 Å) | | 主引用文献 | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
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5H82
 | | HETEROYOHIMBINE SYNTHASE THAS2 FROM CATHARANTHUS ROSEUS - APO FORM | | 分子名称: | ZINC ION, heteroyohimbine synthase THAS2 | | 著者 | Stavrinides, A, Tatsis, E.C, Caputi, L, Foureau, E, Stevenson, C.E.M, Lawson, D.M, Courdavault, V, O'Connor, S.E. | | 登録日 | 2015-12-23 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.
Nat Commun, 7, 2016
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7QP3
 | | Pseudogymnoascus pannorum M36 protease without the propeptide | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Wilkens, C, Qiu, J, Meyer, A.S, Morth, J.P. | | 登録日 | 2021-12-30 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Phaeosphaeria nodorum M36 protease without the propeptide
To Be Published
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5H81
 | | HETEROYOHIMBINE SYNTHASE THAS2 FROM CATHARANTHUS ROSEUS - COMPLEX WITH NADP+ | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION, heteroyohimbine synthase THAS2 | | 著者 | Stavrinides, A, Tatsis, E.C, Caputi, L, Foureau, E, Stevenson, C.E.M, Lawson, D.M, Courdavault, V, O'Connor, S.E. | | 登録日 | 2015-12-23 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.
Nat Commun, 7, 2016
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1F6T
 | | STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX | | 分子名称: | 2*-DEOXY-THYMIDINE-5*-ALPHA BORANO DIPHOSPHATE (ISOMER RP), MAGNESIUM ION, PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE) | | 著者 | Guerreiro, C, Boretto, J, Janin, J, Veron, M, Canard, B, Schneider, B, Sarfati, S, Deville-Bonne, D. | | 登録日 | 2000-06-23 | | 公開日 | 2000-09-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
EMBO J., 19, 2000
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5HHK
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9B2S
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9B2T
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8VH5
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