4L4Z

Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition

Summary for 4L4Z

• Entry DOI: 10.2210/pdb4l4z/pdb
• Related: 4L4Y 4L50 4L51 4L5I 4L5J
• Descriptor: Transcriptional regulator LsrR, (2S)-2,3,3-trihydroxy-4-oxopentyl dihydrogen phosphate (3 entities in total)
• Functional Keywords: dna transcriptional regulator, phospho-ai-2 binding, dna binding, transcription regulator, removed helix-turn-helix domain, sorc/deor family
• Biological source: Escherichia coli
• Cellular location: Cytoplasm (Potential): P76141
• Total number of polymer chains: 2
• Total formula weight: 56308.48

Authors

Ryu, K.S.,Ha, J.H.,Eo, Y. (deposition date: 2013-06-10, release date: 2013-11-06, Last modification date: 2024-02-28)

• Primary citation: Ha, J.H.,Eo, Y.,Grishaev, A.,Guo, M.,Smith, J.A.,Sintim, H.O.,Kim, E.H.,Cheong, H.K.,Bentley, W.E.,Ryu, K.S.; Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition.; J.Am.Chem.Soc., 135:15526-15535, 2013; PubMed: 24047255; DOI: 10.1021/ja407068v

Experimental method

X-RAY DIFFRACTION (2.3 Å)